Results 21 to 30 of about 16,425 (239)

Mutational scanning reveals the determinants of protein insertion and association energetics in the plasma membrane

eLife, 2016
Insertion of helix-forming segments into the membrane and their association determines the structure, function, and expression levels of all plasma membrane proteins. However, systematic and reliable quantification of membrane-protein energetics has been
Assaf Elazar, Jonathan Weinstein, Ido Biran, Yearit Fridman, Eitan Bibi, Sarel Jacob Fleishman   +5 more
doaj   +1 more source

microRNA‐122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma

Molecular Systems Biology, 2010
Tumorigenesis involves multistep genetic alterations. To elucidate the microRNA (miRNA)–gene interaction network in carcinogenesis, we examined their genome‐wide expression profiles in 96 pairs of tumor/non‐tumor tissues from hepatocellular carcinoma ...
Julja Burchard, Chunsheng Zhang, Angela M Liu, Ronnie T P Poon, Nikki P Y Lee, Kwong‐Fai Wong, Pak C Sham, Brian Y Lam, Mark D Ferguson, George Tokiwa, Ryan Smith, Brendan Leeson, Rebecca Beard, John R Lamb, Lee Lim, Mao Mao, Hongyue Dai, John M Luk   +17 more
doaj   +1 more source

Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders. Reverse engineering gene networks to identify key drivers of complex disease phenotypes

Journal of Lipid Research, 2006
Diseases such as obesity, diabetes, and atherosclerosis result from multiple genetic and environmental factors, and importantly, interactions between genetic and environmental factors. Identifying susceptibility genes for these diseases using genetic and
Eric E. Schadt, Pek Y. Lum
doaj   +1 more source

Incorporation of noncanonical amino acids into Rosetta and use in computational protein-peptide interface design. [PDF]

PLoS ONE, 2012
Noncanonical amino acids (NCAAs) can be used in a variety of protein design contexts. For example, they can be used in place of the canonical amino acids (CAAs) to improve the biophysical properties of peptides that target protein interfaces. We describe
P Douglas Renfrew, Eun Jung Choi, Richard Bonneau, Brian Kuhlman   +3 more
doaj   +1 more source

Construction and Characterization of T7 Bacteriophages Harboring Apidaecin-Derived Sequences

Current Issues in Molecular Biology, 2022
The global spread of multi- and pan-resistant bacteria has triggered research to identify novel strategies to fight these pathogens, such as antimicrobial peptides and, more recently, bacteriophages.
Tobias Ludwig, Ralf Hoffmann, Andor Krizsan   +2 more
doaj   +1 more source

Dust Impact Monitor DIM Onboard Rosetta / Philae: Comparison of experimental Results and the Theory behind the Experiment [PDF]

, 2013
The Rosetta lander spacecraft Philae will land on the nucleus surface of comet 67P/Churyumov-Gerasimenko in November 2014. Philae is equipped with the Dust Impact Monitor (DIM).
Seidensticker, Klaus J., Sperl, M., Arnold, W., Sperl, Matthias, Arnold, Walter, Flandes, A., Krüger, H., Fischer, Hans­-Herbert, Flandes, Alberto, Fischer, H., Krueger, Harald, Hirn, Attila, Seidensticker, Klaus Jürgen, Loose, A., Loose, Alexander, Seidensticker, Klaus Juergen, Fischer, Hans-Herbert, Seidensticker, K., Krüger, Harald   +18 more
core   +1 more source

Chromosome 20q Amplification Regulates Response to Kinesin-5 Inhibitor

Cancer Informatics, 2008
We identified gene expression signatures predicting responsiveness to a Kinesin-5 (KIF11) inhibitor (Kinesin-5i) in cultured colon tumor cell lines.
Aimee L. Jackson, Mao Mao, Sumire Kobayashi, Teresa Ward, Matthew Biery, Hongyue Dai, Steven R. Bartz, Peter S. Linsley   +7 more
doaj   +1 more source

Real-time PyMOL visualization for Rosetta and PyRosetta. [PDF]

PLoS ONE, 2011
Computational structure prediction and design of proteins and protein-protein complexes have long been inaccessible to those not directly involved in the field.
Evan H Baugh, Sergey Lyskov, Brian D Weitzner, Jeffrey J Gray   +3 more
doaj   +1 more source

Histological and physiological changes of potato starch derived from seed and TPS (true potato seed) grown tubers under different cold storage duration

Advances in Horticultural Science, 2021
Starch granules in potato tubers exist with varying sizes and size distribution in nature. In this study both the tubers of seed potato (‘Lady Rosetta’) and true potato seed (TPS) (‘BARI TPS-1’) varieties were stored at 5º C for 0 to 4 months, and the ...
Tropa Taufique, Takashi Nishizawa, Tuhin Suvra Roy, Kikuchi Meiko, Rajesh Chakraborty, Maruf Mostofa, Kazuhiro Nara   +6 more
doaj   +1 more source

CS-ROSETTA

, 2019
Chemical Shift-Rosetta (CS-Rosetta) is an automated method that employs NMR chemical shifts to model protein structures de novo. In this chapter, we introduce the terminology and central concepts of CS-Rosetta. We describe the architecture and functionality of automatic NOESY assignment (AutoNOE) and structure determination protocols (Abrelax and ...
Santrupti, Nerli, Nikolaos G, Sgourakis
openaire   +3 more sources