Results 11 to 20 of about 90,351 (277)

Construction and Characterization of T7 Bacteriophages Harboring Apidaecin-Derived Sequences

Current Issues in Molecular Biology, 2022
The global spread of multi- and pan-resistant bacteria has triggered research to identify novel strategies to fight these pathogens, such as antimicrobial peptides and, more recently, bacteriophages.
Tobias Ludwig, Ralf Hoffmann, Andor Krizsan   +2 more
doaj   +1 more source

The Rosetteless gene controls development in the choanoflagellate S. rosetta. [PDF]

, 2014
The origin of animal multicellularity may be reconstructed by comparing animals with one of their closest living relatives, the choanoflagellate Salpingoeca rosetta.
Greaney, Allison J, King, Nicole, Levin, Tera C, Wetzel, Laura   +3 more
core   +1 more source

Incorporation of noncanonical amino acids into Rosetta and use in computational protein-peptide interface design. [PDF]

PLoS ONE, 2012
Noncanonical amino acids (NCAAs) can be used in a variety of protein design contexts. For example, they can be used in place of the canonical amino acids (CAAs) to improve the biophysical properties of peptides that target protein interfaces. We describe
P Douglas Renfrew, Eun Jung Choi, Richard Bonneau, Brian Kuhlman   +3 more
doaj   +1 more source

Solar-insolation-induced changes in the coma morphology of comet 67P/Churyumov-Gerasimenko. Optical monitoring with the Nordic Optical Telescope [PDF]

, 2017
Context. 67P/Churyumov-Gerasimenko (67P/C-G) is a short-period Jupiter family comet with an orbital period of 6.55 years. Being the target comet of ESA’s Rosetta mission, 67P/C-G has become one of the most intensively studied minor bodies of the Solar ...
A. Somero, Accomazzo, B. Zaprudin, Boehnhardt, C. Snodgrass, H. J. Lehto, Hadamcik, K. Nilsson, Knollenberg, Langevin, Merouane, Moreno, Preusker, R. Schulz, Schulz, Sekanina, Snodgrass, T. Pursimo, Vincent, Vincent, Weiler, Zaprudin   +21 more
core   +1 more source

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

microRNA‐122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma

Molecular Systems Biology, 2010
Tumorigenesis involves multistep genetic alterations. To elucidate the microRNA (miRNA)–gene interaction network in carcinogenesis, we examined their genome‐wide expression profiles in 96 pairs of tumor/non‐tumor tissues from hepatocellular carcinoma ...
Julja Burchard, Chunsheng Zhang, Angela M Liu, Ronnie T P Poon, Nikki P Y Lee, Kwong‐Fai Wong, Pak C Sham, Brian Y Lam, Mark D Ferguson, George Tokiwa, Ryan Smith, Brendan Leeson, Rebecca Beard, John R Lamb, Lee Lim, Mao Mao, Hongyue Dai, John M Luk   +17 more
doaj   +1 more source

Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders. Reverse engineering gene networks to identify key drivers of complex disease phenotypes

Journal of Lipid Research, 2006
Diseases such as obesity, diabetes, and atherosclerosis result from multiple genetic and environmental factors, and importantly, interactions between genetic and environmental factors. Identifying susceptibility genes for these diseases using genetic and
Eric E. Schadt, Pek Y. Lum
doaj   +1 more source

A Quantum Rosetta Stone for Interferometry [PDF]

, 2002
Heisenberg-limited measurement protocols can be used to gain an increase in measurement precision over classical protocols. Such measurements can be implemented using, e.g., optical Mach-Zehnder interferometers and Ramsey spectroscopes.
Champollion J. F., Feynman R. P., Helstrom C. W., Hwang Lee, Jonathan P. Dowling, Kimble H. J., Kok P., Kok P., Kok P., Lee H., Pieter Kok, Scully M. O.   +11 more
core   +3 more sources

Spitzer Observations of Comet 67P/Churyumov-Gerasimenko at 5.5-4.3 AU From the Sun [PDF]

, 2009
We report Spitzer Space Telescope observations of comet 67P/Churyumov-Gerasimenko at 5.5 and 4.3 AU from the Sun, post-aphelion. Comet 67P is the primary target of the European Space Agency's Rosetta mission.
Boehnhardt, Hermann, Harker, David E., Kelley, Michael S., Tubiana, Cecilia, Wooden, Diane H., Woodward, Charles E.   +5 more
core   +3 more sources

Real-time PyMOL visualization for Rosetta and PyRosetta. [PDF]

PLoS ONE, 2011
Computational structure prediction and design of proteins and protein-protein complexes have long been inaccessible to those not directly involved in the field.
Evan H Baugh, Sergey Lyskov, Brian D Weitzner, Jeffrey J Gray   +3 more
doaj   +1 more source