Results 121 to 130 of about 27,657 (222)

Rosiglitazone attenuates the metalloprotease/anti-metalloprotease imbalance in emphysema induced by cigarette smoke: involvement of extracellular signal-regulated kinase and NFκB signaling

, 2015
Gang Hou, Yan Yin, Dan Han, Qiu-yue Wang, Jian Kang Department of Respiratory Medicine, the First Hospital of China Medical University, Shenyang, People’s Republic of China Objective: We investigated how rosiglitazone attenuated cigarette smoke ...
Yin Y, Wang QY, Kang J, Han D, Hou G
core  

CYP46A1‐Targeted Treatment Alleviates Long‐Term White Matter Injury Following Traumatic Brain Injury by Promoting Cholesterol Metabolic Clearance and Remyelination

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Our findings demonstrate that CYP46A1 plays a critical role in regulating cholesterol homeostasis in microglia and that the targeting of CYP46A1 may offer a viable therapeutic approach for traumatic brain injury (TBI). The CYP46A1 activator Efavirenz reduces white matter damage by increasing the levels of the cholesterol metabolite 24OHC, thereby ...
Lin Li, You Shi, Qing Luo, Peiwen Guo, Taotao Jin, Xufang Ru, Zhouyang Jiang, Yin Niu, Wenyan Li, Yujie Chen, Zhi Chen   +10 more
wiley   +1 more source

Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy.

, 2006
BACKGROUND: The efficacy of thiazolidinediones, as compared with other oral glucose-lowering medications, in maintaining long-term glycemic control in type 2 diabetes is not known.
Jones, N, Heise, M, Viberti, G, G. VIBERTI, Kahn, S, RR HOLMAN NJ JONES, Lachin, J, Holman, RR, Kahn, SE, B. ZINMANN, Kravitz, B, Holman, Rury, Study Group, ADOPT, O'Neill, M C, JM LACHIN, Zinman, B, MA HEISE, Herman, WH, Jones, NP, Herman, W, Heise, MA, Holman, R, SM HAFFNER, KAHN SE, O'Neill, MC, Lachin, JM, Haffner, SM, BG KRAVITZ, Kravitz, BG, GALLUZZO, Aldo, WH HERMAN, MCOLLEEN O'NEILL, Haffner, S   +32 more
core   +1 more source

The Effect of Carvacrol on Lipid Profiles, Oxidative Stress, Inflammatory Markers, and Renal Injury in STZ‐Induced Diabetic Rats

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Carvacrol administration is associated with improvements in lipid profiles, attenuation of oxidative stress, and modulation of inflammatory markers, including C‐reactive protein (CRP). The diagram summarizes systemic effects across major organs, highlighting potential protective roles against inflammation‐related oxidative damage and kidney injury ...
Vida Seyedmousavi Dijvejin, Vahid Asghariazar, Helda Tutunchi, Elnaz Faramarzi, Hamed Shoorei, Rouhallah Moradpour, Mehdi Asghari Vostakolaei   +6 more
wiley   +1 more source

Microdialysis combined blood sampling technique for the determination of rosiglitazone and glucose in brain and blood of gerbils subjected to cerebral ischemia

, 2012
[[abstract]]Rosiglitazone is a potent synthetic peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist which improves glucose control in the plasma and reduces ischemic brain injury.
鄭秀敏;Cheng, Shiu-Min
core  

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

Evaluating the Endocrine‐Disrupting and Oxidative Stress Potential of a 50‐Component Human‐Relevant Complex Chemical Mixture Using In Vitro Tests

Journal of Applied Toxicology, Volume 46, Issue 6, Page 2003-2018, June 2026.
ABSTRACT Humans are chronically exposed to mixtures of environmental contaminants. Exposure to endocrine‐disrupting chemicals (EDCs) contributes to increased health impairment observed globally. This study aimed to evaluate the endocrine‐disruptive and oxidative stress potential of a human‐relevant, complex chemical mixture in vitro.
Josefin Engelhardt, Nathalie Struwe, Annika Jansson, Vesna Munic Kos, Maria Larsson, Jana M. Weiss   +5 more
wiley   +1 more source

Rosiglitazone and trametinib exhibit potent anti-tumor activity in a mouse model of muscle invasive bladder cancer

Nature Communications
Muscle invasive bladder cancers (BCs) can be divided into 2 major subgroups-basal/squamous (BASQ) tumors and luminal tumors. Since Pparg has low or undetectable expression in BASQ tumors, we tested the effects of rosiglitazone, Pparg agonist, in a mouse ...
Sakina A. Plumber, Tiffany Tate, Hikmat Al-Ahmadie, Xiao Chen, Woonyoung Choi, Merve Basar, Chao Lu, Aaron Viny, Ekatherina Batourina, Jiaqi Li, Kristjan Gretarsson, Besmira Alija, Andrei Molotkov, Gregory Wiessner, Byron Hing Lung Lee, James McKiernan, David J. McConkey, Colin Dinney, Bogdan Czerniak, Cathy Lee Mendelsohn   +19 more
doaj   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, Volume 2, Issue 2, Page 280-308, June 2026.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Rosiglitazone suppresses RANKL‐induced NFATc1 autoamplification by disrupting the physical interaction between NFATc1 and PPARγ

FEBS Open Bio, 2018
Receptor activator of nuclear factor‐κB ligand (RANKL) is required for initiation of osteoclastogenesis, with the signaling pathway including the NF‐kB, c‐Fos, and nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) transcription factors. Because
Kyeong‐Lok Park, Da‐Gyo Oh, Young‐Ok Kim, Kyeong‐Seob Song, Do‐Whan Ahn   +4 more
doaj   +1 more source