Results 91 to 100 of about 31,394 (214)

The farnesoid X receptor -1G>T polymorphism influences the lipid response to rosuvastatin

Journal of Lipid Research, 2012
The bile acid-activated nuclear receptor farnesoid X receptor (FXR) plays an important role in lipid and glucose metabolism, and in addition, it regulates multiple drug transporters involved in statin disposition.
Miao Hu, Sandra S.H. Lui, Lai-Shan Tam, Edmund K. Li, Brian Tomlinson   +4 more
doaj   +1 more source

Gut Microbiome Associates With Lipid-Lowering Effect of Rosuvastatin in Vivo

Frontiers in Microbiology, 2018
Background: Statin has been widely used to treat hyperlipidemia because of its high potency in decreasing cholesterol levels. The present study aimed to examine the lipid-lowering effect of rosuvastatin and the composition, diversity and species ...
Yinhui Liu, Xiaobo Song, Huimin Zhou, Xue Zhou, Yu-yi Xia, Xin Dong, W. Zhong, Shaoying Tang, Lili Wang, S. Wen, Jing Xiao, Li Tang   +11 more
semanticscholar   +1 more source

Uncovering Coenzyme Q10‐Related Genetic Determinants of Statin‐Associated Muscle Symptoms: Evidence from the UK Biobank and the All of Us Research Program

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 475-483, August 2026.
Statin‐associated muscle symptoms (SAMS) are frequent adverse effects of statin therapy and have been hypothesized to result from impaired coenzyme Q10 (CoQ10) biosynthesis. Although genetic determinants of CoQ10 levels have been reported, genome‐wide association studies (GWASs) conducted specifically in statin users are lacking. Moreover, direct CoQ10
Da Hoon Lee, Yoon‐A Park, Yubin Song, Ji‐Min Han, Kyung Hee Choi, Myeong Gyu Kim, Hye Sun Gwak   +6 more
wiley   +1 more source

Optimization of UPLC method for simultaneous determination of rosuvastatin and rosuvastatin degradation products

Acta Chimica Slovenica, 2017
An ultra-performance liquid chromatographic method for simultaneous determination of rosuvastatin and rosuvastatin degradation products was developed and optimized by using fractional factorial experimental design.
Jure Zakrajšek, Katarina Bevc-Černilec, Simona Bohanec, Uroš Urleb   +3 more
doaj   +2 more sources

Rosuvastatin drug as a green and effective inhibitor for corrosion of mild steel in HCl and H2SO4 solutions

Journal of Materials Research and Technology, 2019
The effect of rosuvastatin drug on the corrosion behavior of mild steel in 1.0 M HCl and 0.5 M H2SO4 solutions was investigated using potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) and Fourier transform infrared (FTIR ...
M. Gholamhosseinzadeh, H. Aghaie, M. Zandi, M. Giahi   +3 more
semanticscholar   +1 more source

Biomarker‐Based Prediction of OATP1B1 Activity in Clinical Routine—Investigating Coproporphyrins as Markers for Drug–Drug–Gene Interactions

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 492-500, August 2026.
Coproporphyrin I (CPI) is an established endogenous biomarker for detecting drug–drug interactions (DDIs) involving the hepatic uptake transporter Organic Anion Transporting Polypeptide 1B1 (OATP1B1, gene SLCO1B1). While CPI has been extensively studied in healthy volunteers using controlled pre‐ and post‐OATP1B1‐inhibitor sampling, its applicability ...
Leila Potzel, Anina Zumtaugwald, Anna Bollinger, Chiara Jeiziner, Kurt E. Hersberger, Florine Wiss, Markus L. Lampert, Samuel S. Allemann, Henriette E. Meyer zu Schwabedissen, Céline K. Stäuble   +9 more
wiley   +1 more source

Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 510-519, August 2026.
Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley   +1 more source

Dementia Risk With Combined Statin and Antihypertensive Drugs That Increase Versus Decrease Angiotensin‐II Formation: Findings From the 45 and Up Study

International Journal of Geriatric Psychiatry, Volume 41, Issue 8, August 2026.
ABSTRACT Background Hypertension and dyslipidaemia are key modifiable risk factors of dementia, and the combined use of statins and antihypertensive medications (AHMs) may offer protective benefits. However, evidence on specific combinations remains limited.
Eyayaw Ashete Belachew, Gregory M. Peterson, Mohammed S. Salahudeen, Woldesellassie M. Bezabhe   +3 more
wiley   +1 more source

The Antinociceptive Effects of Rosuvastatin in Chronic Constriction Injury Model of Male Rats

Basic and Clinical Neuroscience, 2018
Introduction: According to studies, statins possess analgesics and anti-inflammatory properties. In the present study, we examined the antinociceptive, anti-inflammatory and antioxidative effects of rosuvastatin in an experimental model of Chronic ...
Amin Hasanvand, Fariba Ahmadizar, Abolfazl Abbaszadeh, Hossein Amini-Khoei, Mehdi Goudarzi, Amir Abbasnezhad, Razieh Choghakhori   +6 more
doaj  

Medications That Regulate Pregnane X Receptor: A Systematic Review of Current Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
PRISMA 2020 flow diagram of study selection for this systematic review of medications that regulate the pregnane X receptor (PXR), from 12 236 records screened to 101 included studies. ABSTRACT The pregnane X receptor (PXR) gene encodes a ligand‐activated protein involved with the metabolism and excretion of drugs, toxins, and other xenobiotics.
Petra Czarniak, Rachael Moorin, Jeff Hughes, Karl Gruber, David Youens   +4 more
wiley   +1 more source