Results 51 to 60 of about 7,528 (253)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Transient High-Frequency Electromagnetic Force Calculation for Linear Induction Motors Under Pulse Width Modulation Current Excitation

Machines
Because of their transient working mode and end effects, it is particularly difficult to compute high-frequency electromagnetic forces on linear induction motors under PWM current simulation.
Mingke Li, Jin Xu, Junjie Zhu, Yuhu Wang, Tairan Chen   +4 more
doaj   +1 more source

Positioning system with backlash compensation by twin motor cooperative control (Evaluation of rectilinear motion mechanism installed planetary gear speed reducer)

Nihon Kikai Gakkai ronbunshu, 2014
Backlash occurs in gear drive systems that are used with machine tools and transport mechanisms. The problem with backlash is that it reduces positioning accuracy and tends to cause vibrations.
Toyokazu UCHIDA, Akihito ITO, Toshiya KITAMURA, Nobuyuki FURUYA   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Structural Design and Test of Mechanical Rotary Percussion Drilling Tool

Shiyou jixie, 2020
Rotary percussion drilling technology can greatly increase the ROP of hard formations, but for plastic rocks, rock fragmentation is poor. For this reason, this paper proposes a technical plan for mechanical rotary percussion drilling tool prototype ...
Zhang Haiping
doaj  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Design and experimental study of tillage depth control system for electric rotary tiller based on LADRC

Scientific Reports
This paper proposes an adaptive real-time tillage depth control system for electric rotary tillers, based on Linear Active Disturbance Rejection Control (LADRC), to improve tillage depth accuracy in tea garden intercropping with soybeans.
Wei Tao, Bin Chen, Xinkun Yang, Bo Guo, Wanwan Xu, Shaoye Ke, Shenghong Huang   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Numerical Modeling of Dynamic Behavior and Steering Ability of a Bottom Hole Assembly with a Bent-Housing Positive Displacement Motor Under Rotary Drilling Conditions

Energies, 2018
Fully rotary drilling is one of many useful technologies used for the exploitation of petroleum and geothermal resources, but fully rotating drill-strings are extremely complicated.
Yingjie Chen, Jianhong Fu, Tianshou Ma, Anping Tong, Zhaoxue Guo, Xudong Wang   +5 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source