Results 41 to 50 of about 271,704 (308)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Whole exome sequencing identifies novel variants of PIK3CA and validation of hotspot mutation by droplet digital PCR in breast cancer among Indian population

Cancer Cell International, 2023
Background Breast cancer (BC) is the most common malignancy with very high incidence and relatively high mortality in women. The PIK3CA gene plays a pivotal role in the pathogenicity of breast cancer.
Rahul Kumar, Rakesh Kumar, Harsh Goel, Sonu Kumar, Somorjit Singh Ningombam, Imran Haider, Usha Agrawal, Svs Deo, Ajay Gogia, Atul Batra, Ashok Sharma, Sandeep Mathur, Amar Ranjan, Anita Chopra, Showket Hussain, Pranay Tanwar   +15 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

In Vitro Research Methods Used to Evaluate Shaping Ability of Rotary Endodontic Files—A Literature Review

Dentistry Journal
Background/Objectives: In this article, we present a literature review of methods used to measure the shaping ability of endodontic rotary files, including the selection of endodontic sample type (extracted teeth versus simulated blocks) and an imaging ...
Ranya F. Elemam, Ana Mano Azul, João Dias, Khaled El Sahli, Renato de Toledo Leonardo   +4 more
doaj   +1 more source

Guidance for otolaryngology health care workers performing aerosol generating medical procedures during the COVID-19 pandemic

Journal of Otolaryngology - Head and Neck Surgery, 2020
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for Coronavirus disease 2019 (COVID-19) has a predilection for infecting the mucosa of the upper and lower airways.
Marc J. W. Lammers, Jane Lea, Brian D. Westerberg   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Rotary beginnings

, 2012
A memo sent to the Toledo Rotary Club asking about the history of the Toledo Rotary ...
Toledo Rotary Club, Rotary International
core   +1 more source

Effect of Motion Kinematics on Microcrack Formation in Root Canals: A Micro-CT Study

Journal of Orofacial Sciences
Introduction: High friction and narrow root canal openings cause stress concentrations that cause dentinal abnormalities, including microcracks that can lead to catastrophic root fractures.
Mohini Nayak, Swaroop Hegde, Shruthi Nagaraja, Dinesh Kalasaiah, Poornima Ramesh   +4 more
doaj   +1 more source

Comparison of apical transportation and centering ability of Mtwo and Reciproc R25 in severely curved canals using cone-beam computed tomography

Dental Research Journal, 2018
Background: Apical transportation (AT) of the root canal moves the physiologic canal terminus to a new location on the external root surface and results in the accumulation of debris and residual microorganisms due to inadequate cleaning and shaping of ...
Abbas Mesgarani, Mahmoud Reza Hamidi, Sina Haghanifar, Shabnam Naiemi, Ali Bijani   +4 more
doaj   +1 more source