Results 41 to 50 of about 31,209 (267)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Optimization of the setup position of a workpiece for five-axis machining to reduce machining time
Advances in Mechanical Engineering, 2020 Five-axis machining is commonly used for complicated features due to its advantage of rotary movement. However, the rotary movement introduces nonlinear terms in the kinematic transform.
Ching-chih Wei, Wei-chen Lee
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
AgricultureThe layered soil crushing rotary tillage machine with L-shaped reclamation rotary blades and rotary-reclamation rotary blades combination was designed to deal with the problems of a low soil fragmentation rate, low straw mulching rate, and poor surface ...
Zhuang Zhao +5 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Jixie chuandong, 2010 In a direct-drive high-power A/C-axis bi-rotary milling head,torque is transferred by two parallel connected rotary direct drive motors of C-axis,therefore,the length of the transmission components of C axis are considerably large,and they are borne high
林剑峰, 闫明, 郑鹏, 孙淑霞
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2020 We suggested a novel method to maintain a machined surface quality of a curved surface shape by synchronous motion between two linear axes and a rotary axis with the five-axis machining center.
Takamaru SUZUKI +3 more
doaj +1 more source