Results 61 to 70 of about 63,875 (265)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Rayleigh–Bénard convection instabilities in a cylindrical container with a rotating lid

open access: yesCase Studies in Thermal Engineering
This study employed the spectral element method for systematically linear stability analysis on Rayleigh–Bénard convection (RBC) instabilities in a cylindrical container with a rotating lid, determining the complete critical stability curves.
Hao Liu   +5 more
doaj   +1 more source

The Influence of Crack Modes on the Elastic Wave Propagation Characteristics in a Non-Uniform Rotating Shaft

open access: yesApplied Sciences, 2018
The transverse crack in a non-uniform shaft possesses different crack modes, and it can affect the propagation characteristics of the elastic waves in the shaft.
Yimin Wei, Xuan Shi, Qi Liu, Wenhua Chen
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Orbital Angular Momentum (OAM) of Rotating Modes Driven by Electrons in Electron Cyclotron Masers

open access: yesScientific Reports, 2017
The well-defined orbital angular momentum (OAM) of rotating cavity modes operating near the cutoff frequency excited by gyrating electrons in a high-power electron cyclotron maser (ECM)—a gyrotron—has been derived by photonic and electromagnetic wave ...
Ashwini Sawant   +3 more
doaj   +1 more source

Rotating axis measurement based on rotational Doppler effect of spliced superposed optical vortex

open access: yesNanophotonics, 2023
In most rotational Doppler effect (RDE) measurements, the optical axis and the rotating axis of the object are required to be aligned. However, the condition is very difficult to achieve in practical applications of rotation detection, which seriously ...
Zhu Xiangyang   +7 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Decoupling of translational and rotational modes for a quantum soliton [PDF]

open access: yesPhysics Letters B, 1993
13 pages, Standard ...
Dubikovsky, A., Sveshnikov, K.
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

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