Results 41 to 50 of about 63,574 (265)
Advances in Civil Engineering, 2021 Beam slab structure is often encountered in a complex tunnel boring machine. Beam slab structure is subject to dynamic load, which is easy to cause fatigue damage and affect its service life.
Chuanlu Zhou +3 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A Review on Variational Mode Decomposition for Rotating Machinery Diagnosis
MATEC Web of Conferences, 2019 Signal processing method is very important in most diagnosis approach for rotating machinery due to non-linearity, non-stationary and noise signals. Recently, a new adaptive signal decomposition method has been proposed by Dragomiretskiy and Zosso known ...
Isham M. Firdaus +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
A spin on Hagedorn temperatures and string stars
Journal of High Energy PhysicsWe discuss the correspondence between highly excited strings and black holes in the presence of angular momentum. At fixed imaginary angular velocity ν, we show that free strings exhibit a Hagedorn instability due to a thermal-winding mode turning ...
Josef Seitz, Erez Y. Urbach
doaj +1 more source
A Mode of producing Arago's Rotation [PDF]
Proceedings of the Physical Society of London, 1879 n ...
openaire +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Rapidly rotating wall-mode convection
Journal of Fluid MechanicsIn the rapidly rotating limit, we derive a balanced set of reduced equations governing the strongly nonlinear development of the convective wall-mode instability in the interior of a general container. The model illustrates that wall-mode convection is a multiscale phenomenon where the dynamics of the bulk interior diagnostically determine the small ...
Geoffrey M. Vasil +5 more
openaire +3 more sources