Results 41 to 50 of about 63,875 (265)
Advances in Civil Engineering, 2021 Beam slab structure is often encountered in a complex tunnel boring machine. Beam slab structure is subject to dynamic load, which is easy to cause fatigue damage and affect its service life.
Chuanlu Zhou +3 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
A Review on Variational Mode Decomposition for Rotating Machinery Diagnosis
MATEC Web of Conferences, 2019 Signal processing method is very important in most diagnosis approach for rotating machinery due to non-linearity, non-stationary and noise signals. Recently, a new adaptive signal decomposition method has been proposed by Dragomiretskiy and Zosso known ...
Isham M. Firdaus +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
A spin on Hagedorn temperatures and string stars
Journal of High Energy PhysicsWe discuss the correspondence between highly excited strings and black holes in the presence of angular momentum. At fixed imaginary angular velocity ν, we show that free strings exhibit a Hagedorn instability due to a thermal-winding mode turning ...
Josef Seitz, Erez Y. Urbach
doaj +1 more source
A Mode of producing Arago's Rotation [PDF]
Proceedings of the Physical Society of London, 1879 n ...
openaire +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Rapidly rotating wall-mode convection
Journal of Fluid MechanicsIn the rapidly rotating limit, we derive a balanced set of reduced equations governing the strongly nonlinear development of the convective wall-mode instability in the interior of a general container. The model illustrates that wall-mode convection is a multiscale phenomenon where the dynamics of the bulk interior diagnostically determine the small ...
Geoffrey M. Vasil +5 more
openaire +3 more sources