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Rotavirus

Clinics in Laboratory Medicine, 2015
Group A rotavirus (RVA) is the major cause of acute gastroenteritis (AGE) in young children worldwide. Introduction of two live, attenuated rotavirus vaccines, Rotarix® and RotaTeq®, has dramatically reduced RVA-associated AGE and mortality. High-throughput, sensitive and specific techniques are required to rapidly diagnose and characterize rotavirus ...
Mathew D, Esona, Rashi, Gautam
openaire   +2 more sources

Rotavirus and Rotavirus Vaccines

2006
Two new rotavirus vaccines have recently been licensed that will provide the intervention needed to diminish the huge burden of rotavirus disease among all children. In many upper and middle income countries, these vaccines will soon be available for the routine immunization of children.
Roger I, Glass   +5 more
openaire   +2 more sources

Impact of rotavirus vaccines on rotavirus disease

Expert Review of Anti-infective Therapy, 2012
Rotaviruses are the most common cause of acute gastroenteritis in young children worldwide. Both licensed rotavirus vaccines (Rotarix™ [RV1] and RotaTeq™ [RV5]) are effective and safe. Studies from countries that have included RV1 or RV5 in the national immunization programs have demonstrated their safety and sustained efficacy under real-life ...
Lepage, Philippe, Vergison, Anne
openaire   +3 more sources

ROTAVIRUS GASTROENTERITIS

Annual Review of Medicine, 1987
Rotaviruses have proven to be major causes of pediatric diarrheal disease morbidity and mortality worldwide. The past several years have yielded substantial new insights into these viruses, their epidemiology, and the mechanisms of host resistance to them.
A V, Bartlett   +3 more
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Rotavirus

Clinics in Laboratory Medicine, 1999
Rotavirus is the leading cause of nonbacterial gastroenteritis in young children and may infect neonates, older children, and adults as well. A large number of serogroups and types complicates the study, epidemiology, diagnosis, and prevention of rotaviral illness. Currently, routine diagnostic methods are satisfactory only for group A rotaviruses, and
openaire   +2 more sources

Rotavirus gastroenteritis

Advances in Therapy, 2005
Rotavirus is the single most important cause of severe, dehydrating gastroenteritis in infants and young children worldwide. Rotavirus gastroenteritis is associated with high morbidity in developed countries and significant mortality in developing countries. Virtually all children are infected with rotavirus by 3 years of age.
Alexander K C, Leung   +2 more
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Rotavirus vaccines

Scandinavian Journal of Infectious Diseases, 2008
Two live attenuated oral rotavirus vaccines were licensed in 2006 for prevention of severe acute gastroenteritis in children: Rotarix (GSK), a human rotavirus vaccine with G1P[8] serotype characteristics and RotaTeq (Merck), a bovine-human reassortant vaccine expressing human G1-4 and P[8] antigens.
openaire   +3 more sources

Rotavirus vaccines

Current Opinion in Infectious Diseases, 2000
The past few years have seen important developments in understanding the epidemiological and virological characteristics of rotaviruses, and rapid progress has been made in rotavirus vaccine development, but further challenges remain before a vaccine is introduced into widespread use.
Maureen, Lynch   +3 more
openaire   +2 more sources

The rotavirus vaccine

Journal of Clinical Virology, 1998
Rotavirus gastroenteritis is an important cause of morbidity and mortality worldwide.To review the biology, immunology, and virology of rotavirus infections and describe the efforts towards the construction of vaccines using human and animal rotaviruses.A review of the literature and provision of the author's understanding and speculation of ...
openaire   +2 more sources

The rotavirus vaccine

Current Opinion in Pediatrics, 1999
A rotavirus vaccine was recently licensed by the Food and Drug Administration and is likely to be recommended for use in all infants by both the Advisory Committee on Immunization Practices and the American Academy of Pediatrics. If used as recommended, the vaccine is likely to prevent much of the 500,000 physician visits, 50,000 hospitalizations, and ...
P A, Offit, H F, Clark
openaire   +2 more sources

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