Estimating the global impact of rotavirus vaccines on child mortality [PDF]
International Journal of Infectious Diseases, 2023 Objectives: We estimated the global impact of rotavirus vaccines on deaths among children under five years old by year. Methods: We used a proportionate outcomes model with a finely disaggregated age structure to estimate rotavirus deaths prevented by ...
Andrew Clark +10 more
doaj +2 more sources
The Challenges and Opportunities of Next-Generation Rotavirus Vaccines: Summary of an Expert Meeting with Vaccine Developers [PDF]
Viruses, 2022 The 2nd Next Generation Rotavirus Vaccine Developers Meeting, sponsored by PATH and the Bill and Melinda Gates Foundation, was held in London, UK (7–8 June 2022), and attended by vaccine developers and researchers to discuss advancements in the ...
Jessie Chen +5 more
doaj +2 more sources
The performance of licensed rotavirus vaccines and the development of a new generation of rotavirus vaccines: a review [PDF]
Human Vaccines & Immunotherapeutics, 2021 Rotavirus, which causes acute gastroenteritis and severe diarrhea, has posed a great threat to children worldwide over the last 30 y. Since no specific drugs and therapies against rotavirus are available, vaccination is considered the most effective ...
Yuxiao Wang +3 more
doaj +2 more sources
Leveraging Beneficial Off-Target Effects of Live-Attenuated Rotavirus Vaccines [PDF]
Vaccines, 2022 Following the introduction of live-attenuated rotavirus vaccines in many countries, a notable reduction in deaths and hospitalisations associated with diarrhoea in children
Prisca Benedicto-Matambo +11 more
doaj +2 more sources
Immune response to rotavirus vaccines in low- and middle-income countries: Challenges and perspectives [PDF]
Human Vaccines & ImmunotherapeuticsRotavirus is a highly contagious pathogen and a leading cause of severe diarrhea cases in children under 5 y of age worldwide. Although effective oral rotavirus vaccines have been developed and implemented globally, their performance varies substantially
Elena Morandi +5 more
doaj +2 more sources
Update on Early-Life T Cells: Impact on Oral Rotavirus Vaccines [PDF]
VirusesRotavirus infection continues to be a significant public health problem in developing countries, despite the availability of several vaccines. The efficacy of oral rotavirus vaccines in young children may be affected by significant immunological ...
Catherine Montenegro +2 more
doaj +2 more sources
Product review of the rotavirus vaccines ROTASIIL, ROTAVAC, and Rotavin-M1 [PDF]
Human Vaccines & Immunotherapeutics, 2021 Rotavirus is the leading cause of severe dehydrating gastroenteritis and death due to diarrhea among children under 5, causing over 180,000 under-5 deaths annually.
Annika Skansberg +4 more
doaj +2 more sources
Human Vaccines and Immunotherapeutics, 2021 In the decade since oral rotavirus vaccines (ORV) were recommended by the World Health Organization for universal inclusion in all national immunization programs, significant yet incomplete progress has been made toward reducing the burden of rotavirus ...
Benjamin Lee
exaly +2 more sources
Overview of the Development, Impacts, and Challenges of Live-Attenuated Oral Rotavirus Vaccines
Vaccines, 2020 Safety, efficacy, and cost-effectiveness are paramount to vaccine development. Following the isolation of rotavirus particles in 1969 and its evidence as an aetiology of severe dehydrating diarrhoea in infants and young children worldwide, the quest to ...
Olihile M Sebolai +1 more
exaly +3 more sources
Indirect protection from rotavirus vaccines: a systematic review [PDF]
Expert Review of VaccinesIntroduction Rotavirus vaccines may provide indirect protection by reducing transmission in the population and thus reducing disease burden.Methods This systematic review summarizes estimates of indirect protection from rotavirus vaccines and the methods
Tyler Chavers +4 more
doaj +2 more sources