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Journal of Clinical Virology, 1998
Rotavirus gastroenteritis is an important cause of morbidity and mortality worldwide.To review the biology, immunology, and virology of rotavirus infections and describe the efforts towards the construction of vaccines using human and animal rotaviruses.A review of the literature and provision of the author's understanding and speculation of ...
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Rotavirus gastroenteritis is an important cause of morbidity and mortality worldwide.To review the biology, immunology, and virology of rotavirus infections and describe the efforts towards the construction of vaccines using human and animal rotaviruses.A review of the literature and provision of the author's understanding and speculation of ...
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Rotavirus Vaccines and Vaccination Potential
1994The development of a successful rotavirus vaccine is a complex problem. Our review of rotavirus vaccine development shows that many challenges remain, and priorities for future studies need to be established. For example, the evaluation of administration of a vaccine with OPV or breast milk might receive less emphasis until a vaccine is made that shows
M E, Conner, D O, Matson, M K, Estes
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The Pediatric Infectious Disease Journal, 2005
Rotavirus was discovered in 1973, and 10 years later the first report of a rotavirus vaccine clinical trial appeared. This update reviews the epidemiology of rotavirus infections, assesses past and current vaccines and presents ideas for implementation of vaccination programs in developed and developing countries.
Joseph S, Bresee +5 more
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Rotavirus was discovered in 1973, and 10 years later the first report of a rotavirus vaccine clinical trial appeared. This update reviews the epidemiology of rotavirus infections, assesses past and current vaccines and presents ideas for implementation of vaccination programs in developed and developing countries.
Joseph S, Bresee +5 more
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Rotavirus vaccines—An update
Vaccine, 2005Rotavirus infection is the most common cause of severe diarrhea disease in infants and young children worldwide and has a major global impact on childhood morbidity and mortality. Vaccination is the only control measure likely to have a significant impact on the incidence of severe dehydrating rotavirus disease.Rotavirus disease prevention efforts ...
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Pediatric Drugs, 2006
RotaTeq is a live, oral, pentavalent human-bovine reassortant rotavirus vaccine approved for use in the prevention of G1-G4 rotavirus gastroenteritis in infants and children. Rotavirus vaccine demonstrated good immunogenicity in healthy infants. Three oral doses of rotavirus vaccine had a protective efficacy against G1-G4 rotavirus gastroenteritis of ...
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RotaTeq is a live, oral, pentavalent human-bovine reassortant rotavirus vaccine approved for use in the prevention of G1-G4 rotavirus gastroenteritis in infants and children. Rotavirus vaccine demonstrated good immunogenicity in healthy infants. Three oral doses of rotavirus vaccine had a protective efficacy against G1-G4 rotavirus gastroenteritis of ...
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Annals of Pharmacotherapy, 1999
OBJECTIVE: To review the clinical efficacy, safety, and pharmacoeconomic data about the use of rhesus–human reassortant rotavirus tetravalent vaccine (RRV-TV) in infants and children. DATA SOURCES: A MEDLINE search (January 1990 ...
T L, Wandstrat +3 more
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OBJECTIVE: To review the clinical efficacy, safety, and pharmacoeconomic data about the use of rhesus–human reassortant rotavirus tetravalent vaccine (RRV-TV) in infants and children. DATA SOURCES: A MEDLINE search (January 1990 ...
T L, Wandstrat +3 more
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Intussusception and rotavirus vaccines
Vaccine, 2006The association between the first oral rotavirus vaccine to be licensed in the U.S. (Rotashield) and intussusception has presented a major challenge to the effort to reduce the global burden related to rotavirus infection. Although the risk of developing intussusception following immunization with Rotashield is low, debate continues about the ...
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1996
We evaluated rotavirus subunit vaccines for use in humans and animals. Insect cells were co-infected with combinations of individual baculovirus recombinants expressing human, bovine or simian rotavirus VP2, VP4, VP6 or VP7 to produce virus-like particles (VLPs).
Conner, M.E. +9 more
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We evaluated rotavirus subunit vaccines for use in humans and animals. Insect cells were co-infected with combinations of individual baculovirus recombinants expressing human, bovine or simian rotavirus VP2, VP4, VP6 or VP7 to produce virus-like particles (VLPs).
Conner, M.E. +9 more
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Rotavirus vaccination programmes
BMJ, 2012Early results are promising and programmes should be adopted more widely In a linked research paper (doi:10.1136/bmj.e4752), Braeckman and colleagues analyse the effectiveness of a monovalent rotavirus vaccine after its routine introduction in Belgium.1 This is the first study of its kind from Europe, and the new data offer robust evidence on the ...
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Pediatric Infectious Disease Journal, 2011
: The current Belgian experience with rotavirus vaccination provides a unique perspective to look at the effect of vaccination. Shortly after introduction, a nation-wide recommendation was issued and despite the fact that both rotavirus vaccines are offered through partial reimbursement, vaccine uptake has already reached a high level (at least 90 ...
Braeckman, Tessa +5 more
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: The current Belgian experience with rotavirus vaccination provides a unique perspective to look at the effect of vaccination. Shortly after introduction, a nation-wide recommendation was issued and despite the fact that both rotavirus vaccines are offered through partial reimbursement, vaccine uptake has already reached a high level (at least 90 ...
Braeckman, Tessa +5 more
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