Indian Journal of Medical Microbiology, 2006 Rotavirus, the most common cause of severe diarrhea and a leading cause of mortality in children, has been a priority target for vaccine development for the past several years. The first rotavirus vaccine licensed in the United States was withdrawn because of an association of the vaccine with intussusception.
europepmc +6 more sources
Estimating the global impact of rotavirus vaccines on child mortality [PDF]
International Journal of Infectious Diseases, 2023 Objectives: We estimated the global impact of rotavirus vaccines on deaths among children under five years old by year. Methods: We used a proportionate outcomes model with a finely disaggregated age structure to estimate rotavirus deaths prevented by ...
Andrew Clark +10 more
doaj +2 more sources
The Challenges and Opportunities of Next-Generation Rotavirus Vaccines: Summary of an Expert Meeting with Vaccine Developers [PDF]
Viruses, 2022 The 2nd Next Generation Rotavirus Vaccine Developers Meeting, sponsored by PATH and the Bill and Melinda Gates Foundation, was held in London, UK (7–8 June 2022), and attended by vaccine developers and researchers to discuss advancements in the ...
Jessie Chen +5 more
doaj +2 more sources
The performance of licensed rotavirus vaccines and the development of a new generation of rotavirus vaccines: a review [PDF]
Human Vaccines & Immunotherapeutics, 2021 Rotavirus, which causes acute gastroenteritis and severe diarrhea, has posed a great threat to children worldwide over the last 30 y. Since no specific drugs and therapies against rotavirus are available, vaccination is considered the most effective ...
Yuxiao Wang +3 more
doaj +2 more sources
Leveraging Beneficial Off-Target Effects of Live-Attenuated Rotavirus Vaccines [PDF]
Vaccines, 2022 Following the introduction of live-attenuated rotavirus vaccines in many countries, a notable reduction in deaths and hospitalisations associated with diarrhoea in children
Prisca Benedicto-Matambo +11 more
doaj +2 more sources
Update on Early-Life T Cells: Impact on Oral Rotavirus Vaccines [PDF]
VirusesRotavirus infection continues to be a significant public health problem in developing countries, despite the availability of several vaccines. The efficacy of oral rotavirus vaccines in young children may be affected by significant immunological ...
Catherine Montenegro +2 more
doaj +2 more sources
Product review of the rotavirus vaccines ROTASIIL, ROTAVAC, and Rotavin-M1 [PDF]
Human Vaccines & Immunotherapeutics, 2021 Rotavirus is the leading cause of severe dehydrating gastroenteritis and death due to diarrhea among children under 5, causing over 180,000 under-5 deaths annually.
Annika Skansberg +4 more
doaj +2 more sources
Indirect protection from rotavirus vaccines: a systematic review [PDF]
Expert Review of VaccinesIntroduction Rotavirus vaccines may provide indirect protection by reducing transmission in the population and thus reducing disease burden.Methods This systematic review summarizes estimates of indirect protection from rotavirus vaccines and the methods
Tyler Chavers +4 more
doaj +2 more sources
A cost effectiveness and capacity analysis for the introduction of universal rotavirus vaccination in Kenya : comparison between Rotarix and RotaTeq vaccines [PDF]
, 2012 Background Diarrhoea is an important cause of death in the developing world, and rotavirus is the single most important cause of diarrhoea associated mortality. Two vaccines (Rotarix and RotaTeq) are available to prevent rotavirus disease.
A Kerdpanich +29 more
core +15 more sources
BMC Infectious Diseases, 2021 Background G12 rotaviruses were first observed in sub-Saharan Africa in 2004 and since then have continued to emerge and spread across the continent and are reported as a significant human rotavirus genotype in several African countries, both prior to ...
Kebareng G. Rakau +6 more
doaj +1 more source