Results 21 to 30 of about 18,676 (131)

Rotavirus Vaccines: a story of success with challenges ahead [version 1; referees: 3 approved]

open access: yesF1000Research, 2017
Approximately 40 years have passed since the discovery of the rotavirus and 10 years since the introduction and progressive dissemination of rotavirus vaccines worldwide.
Miguel O’Ryan
doaj   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

open access: yesXenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Improving rotavirus vaccine coverage: Can newer-generation and locally produced vaccines help?

open access: yesHuman Vaccines & Immunotherapeutics, 2018
There are two internationally available WHO-prequalified oral rotavirus vaccines (Rotarix and RotaTeq), two rotavirus vaccines licensed in India (Rotavac and Rotasiil), one in China (Lanzhou lamb rotavirus vaccine) and one in Vietnam (Rotavin-M1), and ...
Jacqueline Deen   +6 more
doaj   +1 more source

Patterns of rotavirus vaccine uptake and use in privately-insured US infants, 2006-2010. [PDF]

open access: yesPLoS ONE, 2013
Rotavirus vaccines are highly effective at preventing gastroenteritis in young children and are now universally recommended for infants in the US. We studied patterns of use of rotavirus vaccines among US infants with commercial insurance.
Catherine A Panozzo   +6 more
doaj   +1 more source

Bivalent rotavirus VP4∗ stimulates protective antibodies against common genotypes of human rotaviruses

open access: yesiScience, 2022
Summary: Non-replicating rotavirus vaccines are an alternative strategy to improve the efficacy and safety of rotavirus vaccines. The spike protein VP4, which could be enzymatically cleaved into VP8∗ and VP5∗, is an ideal target for the development of ...
Guoxing Luo   +11 more
doaj   +1 more source

Preclinical and clinical development of preventive rotavirus vaccines: special considerations

open access: yesБиопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. Vaccination is recognised as the only effective method for preventing rotavirus disease. Rotavirus remains a leading cause of death in young children, mainly, in developing countries.
A. S. Korovkin   +3 more
doaj   +1 more source

A Novel Rotavirus Reverse Genetics Platform Supports Flexible Insertion of Exogenous Genes and Enables Rapid Development of a High-Throughput Neutralization Assay

open access: yesViruses, 2023
Despite the success of rotavirus vaccines, rotaviruses remain one of the leading causes of diarrheal diseases, resulting in significant childhood morbidity and mortality, especially in low- and middle-income countries. The reverse genetics system enables
Jiajie Wei   +13 more
doaj   +1 more source

Evaluating the potential economic and health impact of rotavirus vaccination in 63 middle-income countries not eligible for Gavi funding: a modelling study

open access: yesThe Lancet Global Health, 2021
Summary: Background: Middle-income countries (MICs) that are not eligible for funding from Gavi, the Vaccine Alliance, have been slow to adopt rotavirus vaccines.
Frédéric Debellut, MSc   +7 more
doaj   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

open access: yesBMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim   +9 more
wiley   +1 more source

Options for improving effectiveness of rotavirus vaccines in developing countries

open access: yesHuman Vaccines & Immunotherapeutics, 2017
Rotavirus gastroenteritis is a leading global cause of mortality and morbidity in young children due to diarrhea and dehydration. Over 85% of deaths occur in developing countries.
Marion S. Tissera   +6 more
doaj   +1 more source

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