Results 41 to 50 of about 32,766 (214)

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Protocol for a Scoping/Systematic Review: Scoping Review of Vaccination for the Prevention of Calf Scours in Cow-Calf Operations [PDF]

, 2020
Background: The use of antimicrobials in the livestock industry has been a topic of increasing concern in the last  few years. Calf scours is one of the main causes of mortality among calves younger than 1 month and affects the development of the animal,
Breitenbuecher, Jefferson GC, Fausak, Erik Davis, Gomez, Jose P, Maier, Gabriele, Van Noord, Megan G   +4 more
core  

On Pediatric Vaccines and Catholic Social Teaching [PDF]

, 2018
Determining whether, and when, to get one\u27s children vaccinated has become an increasingly controversial decision, often leaving parents fearful of making the “wrong” choice.
Bilgrien, Byron, Cahill, Coleman, Eiser, Grady, Heyer, Johnson, Kant, Kelly, Largent, Massaro, Offit, Offit, Offit, Oshinsky, Plotkin, Rubio, Skloot, Sobrino, Tucker   +20 more
core   +2 more sources

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Options for improving effectiveness of rotavirus vaccines in developing countries

Human Vaccines & Immunotherapeutics, 2017
Rotavirus gastroenteritis is a leading global cause of mortality and morbidity in young children due to diarrhea and dehydration. Over 85% of deaths occur in developing countries.
Marion S. Tissera, Daniel Cowley, Nada Bogdanovic-Sakran, Melanie L. Hutton, Dena Lyras, Carl D. Kirkwood, Jim P. Buttery   +6 more
doaj   +1 more source

Tuberculosis and gender: exploring the patterns in a case control study in Malawi. [PDF]

, 2004
BACKGROUND: In many populations there is an excess of tuberculosis in young women and older men. We explored possible explanations for these patterns, concentrating on human immunodeficiency virus (HIV) status, pregnancy, smoking, cooking smoke exposure,
Crampin, AC, Fine, PEM, Floyd, S, Glynn, JR, Malema, SS, Mwaungulu, FD, Mwinuka, VK, Ngwira, BMM, Warndorff, DK   +8 more
core  

Comparative evaluation of the potential impact of rotavirus versus hpv vaccination in GAVI-eligible countries: A preliminary analysis focused on the relative disease burden [PDF]

, 2011
Background Immunization policymakers at global and local levels need to establish priorities among new vaccines competing for limited resources.
Sun-Young Kim, Steven Sweet, Joshua Chang, Sue J Goldie, Kim, Sun-Young   +4 more
core   +1 more source

Trends in hospitalizations for vaccine‐preventable diseases in the United States from 2014 to 2024

Journal of Hospital Medicine, EarlyView.
Abstract Background and Objectives Vaccination rates have declined in recent years, resulting in outbreaks of vaccine‐preventable diseases (VPDs) among children. We aimed to evaluate VPD hospitalization rates from 2014 to 2024 and to report associated trends in outcomes including intensive care utilization, mortality, readmissions, and costs.
Nathan M. Money, Erin Sullivan, Hannah Rector, Corrie E. McDaniel, Jessica L. Markham, Mersine A. Bryan   +5 more
wiley   +1 more source

A Multi-Center, Qualitative Assessment of Pediatrician and Maternal Perspectives on Rotavirus Vaccines and the Detection of Porcine circovirus

BMC Pediatrics, 2011
Background In 2010, researchers using novel laboratory techniques found that US-licensed rotavirus vaccines contain DNA or DNA fragments from Porcine circovirus (PCV), a virus common among pigs but not believed to cause illness in humans.
Locke David, Albertin Christina, Kobayashi Ana, Klein Eileen J, Downing Kimberly, Wikswo Mary, Opel Douglas, Kennedy Allison, Humiston Sharon, Payne Daniel C, Chesley Claudia, Staat Mary A   +11 more
doaj   +1 more source

Phylogenetic analyses of typical bovine rotavirus genotypes G6, G10, P[5] and P[11] circulating in Argentinean beef and dairy herds [PDF]

, 2013
Group A rotavirus (RVA) is one of the main causes of neonatal calf diarrhea worldwide. RVA strains affecting Argentinean cattle mainly possess combinations of the G6, G10, P[5] and P[11] genotypes.
Badaracco, Alejandra, Bilbao, Gladys Noemí, Fernandez, Fernando, Garaicoechea, Lorena Laura, Louge Uriarte, Enrique Leopoldo, Matthijnssens, J., Odeón, Anselmo Carlos, Parra, G. I., Parreño, Gladys Viviana   +8 more
core   +1 more source