Results 41 to 50 of about 18,676 (131)

Trained Immunity in Childhood Vaccination

Acta Paediatrica, EarlyView.
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
ChenRongRong Cai, Lubnaa Hossenbaccus, Eva Kaufmann   +2 more
wiley   +1 more source

Human rotavirus infection. Strategies for the vaccinal prevention

Вопросы вирусологии, 2016
Rotavirus was first isolated in 1973 in Australia from children with diarrhea. Hundreds of thousands of children die annually in developing countries from this virus with the mortality peaks in the most impoverished among them.
K. P. Alekseev, S. L. Kalnov, T. V. Grebennikova, T. I. Aliper   +3 more
doaj   +1 more source

Equine coronavirus: Investigating seroconversion and faecal shedding patterns in naturally occurring field infections

Equine Veterinary Education, EarlyView.
Summary Background Equine coronavirus (ECoV) is an increasingly recognised cause of pyrexia and enteric disease in the horse. Objectives To (1) evaluate if horses seroconvert after clinical ECoV infection and (2) investigate the pattern of faecal excretion of ECoV to determine the optimal testing moment with the overall aim of helping veterinarians in ...
H. C. Smith, M. J. P. Theelen, R. M. A. C. Houben, R. van den Boom, L. van den Wollenberg, V. van Leeuwen, C. van Maanen   +6 more
wiley   +1 more source

Rotavirus in developing countries: molecular diversity, epidemiological insights, and strategies for effective vaccination

Frontiers in Microbiology
Rotavirus (RV) causes the loss of numerous children’s lives worldwide each year, and this burden is particularly heavy in low- and lower-middle-income countries where access to healthcare is limited. RV epidemiology exhibits a diverse range of genotypes,
Asma Sadiq, Jadoon Khan
doaj   +1 more source

Vaccine Safety and Efficacy in Preventing Rotavirus Infection

Биопрепараты: Профилактика, диагностика, лечение, 2019
The rotavirus infection causes acute gastroenteritis and is a major cause of lethal severe dehydrating diarrhoea in children under 5 years of age worldwide.
V. A. Shevtsov, E. E. Evreinova, I. N. Indikova, L. M. Khantimirova, D. V. Gorenkov, A. V. Rukavishnikov   +5 more
doaj   +1 more source

Simultaneous modification of Thermotoga maritima encapsulin subunits to produce multivalent nanoparticle vaccines for non‐typhoidal Salmonella enterica

The FEBS Journal, EarlyView.
This study investigates the modularity of encapsulin—a protein nanoparticle—by simultaneously inserting up to four distinct Salmonella epitopes within the encapsulin subunit. The encapsulin variants were transiently expressed in plants where they assembled into nanoparticles; however, their accumulation and stability varied depending on the ...
Carly A. Charron, Angelo Kaldis, Shabnam Shamriz, Moussa S. Diarra, Christopher P. Garnham, Rima Menassa   +5 more
wiley   +1 more source

Exploring the Relationship Between Respiratory Syncytial Virus and Asthma Using Calendar Time at Birth as a Source of Quasi‐Random Variation

Paediatric and Perinatal Epidemiology, EarlyView.
ABSTRACT Background Observational studies suggest an association between severe respiratory syncytial virus (RSV) and asthma, but it is unclear if this relationship is causal or confounded. Objectives We investigated this relationship using calendar time at birth as a source of quasi‐random variation with respect to individual‐level risk factors for ...
Michelle C. Dimitris, Daniel R. Feikin, Erin Sparrow, Susan E. Schultz, Jeffrey C. Kwong, Sarah A. Buchan, David A. Savitz, Steven M. Brunwasser, Deshayne B. Fell   +8 more
wiley   +1 more source

Health and Survival Impacts of Early Childhood Development Programmes: The Case of the Happy Child Programme in Brazil

Review of Development Economics, EarlyView.
ABSTRACT This paper adds to the growing evidence on the impacts of early childhood development (ECD) programming by examining one of the world's largest home visitation programmes, the Happy Child Programme in Brazil, and its impacts on child vaccination and preventable death rates.
Raquel Tebaldi, Franziska Gassmann, Bruno Martorano   +2 more
wiley   +1 more source

Chimeric Viruses Enable Study of Antibody Responses to Human Rotaviruses in Mice

Viruses
The leading cause of gastroenteritis in children under the age of five is rotavirus infection, accounting for 37% of diarrhoeal deaths in infants and young children globally.
Sarah Woodyear, Tawny L. Chandler, Takahiro Kawagishi, Tom M. Lonergan, Vanshika A. Patel, Caitlin A. Williams, Sallie R. Permar, Siyuan Ding, Sarah L. Caddy   +8 more
doaj   +1 more source

Why does the world need another rotavirus vaccine?

Therapeutics and Clinical Risk Management, 2008
Richard L Ward1, Monica M McNeal1, A Duncan Steele21Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA; 2Initiative for Vaccine Research, World Health Organization, Geneva, SwitzerlandAbstract: A
Richard L Ward, Monica M McNeal, A Duncan Steele   +2 more
doaj