Results 21 to 30 of about 135,736 (315)

Global impact of rotavirus vaccination on diarrhea hospitalizations and deaths among children <5 years old: 2006-2019.

Journal of Infectious Diseases, 2020
Since 2006, more than 100 countries have introduced rotavirus vaccine into their immunization programs. We reviewed published data on relative reductions of rotavirus hospitalizations, acute gastroenteritis (AGE) hospitalizations, and AGE deaths among ...
Eleanor M. Burnett, U. Parashar, J. Tate
semanticscholar   +1 more source

Rotavirus and autoimmunity [PDF]

Journal of Infection, 2020
Rotavirus, a major etiological agent of acute diarrhea in children worldwide, has historically been linked to autoimmunity. In the last few years, several physiopathological approaches have been proposed to explain the leading mechanism triggering autoimmunity, from the old concept of molecular mimicry to the emerging theory of bystander activation and
Antonio Salas, José Gómez-Rial, Federico Martinón-Torres, Irene Rivero-Calle   +3 more
openaire   +3 more sources

Rotavirus Vaccination and the Global Burden of Rotavirus Diarrhea Among Children Younger Than 5 Years

JAMA pediatrics, 2018
Importance Rotavirus infection is the global leading cause of diarrhea-associated morbidity and mortality among children younger than 5 years. Objectives To examine the extent of rotavirus infection among children younger than 5 years by country and the ...
C. Troeger, I. Khalil, P. Rao, Shujin Cao, B. Blacker, T. Ahmed, G. Armah, J. Bines, J. Bines, T. Brewer, D. Colombara, G. Kang, B. Kirkpatrick, C. Kirkwood, J. Mwenda, U. Parashar, W. Petri, M. Riddle, A. Steele, R. Thompson, J. Walson, J. Sanders, A. Mokdad, C. Murray, Simon Iain Hay, R. Reiner   +25 more
semanticscholar   +1 more source

Effect of human rotavirus vaccine on severe diarrhea in African infants. [PDF]

, 2010
BACKGROUND: Rotavirus is the most common cause of severe gastroenteritis among young children worldwide. Data are needed to assess the efficacy of the rotavirus vaccine in African children.
Cheuvart, Brigitte B, Cunliffe, Nigel A, Gillard, Paul H, Han, Htay H, Kirsten, Mari, Louw, Cheryl, Madhi, Shabir A, Neuzil, Kathleen M, Ngwira, Bagrey, Steele, Duncan, Victor, John C, Witte, Desirée   +11 more
core   +3 more sources

Global, Regional, and National Estimates of Rotavirus Mortality in Children <5 Years of Age, 2000-2013.

Clinical Infectious Diseases, 2016
BACKGROUND Rotavirus vaccine is recommended for routine use in all countries globally. To facilitate decision making on rotavirus vaccine adoption by countries, help donors prioritize investments in health interventions, and monitor vaccine impact, we ...
J. Tate, A. Burton, C. Boschi-Pinto, U. Parashar   +3 more
semanticscholar   +1 more source

Rotavirus

Microbiology Spectrum, 2013
ABSTRACTRotaviruses (RV) are ubiquitous, highly infectious, segmented double-stranded RNA genome viruses of importance in public health because of the severe acute gastroenteritis they cause in young children and many animal species. They are very well adapted to their host, with symptomatic and asymptomatic reinfections being virtually universal ...
Franco, Manuel A., Greenberg, Harry B.
openaire   +3 more sources

Putative E3 Ubiquitin Ligase of Human Rotavirus Inhibits NF-κB Activation by Using Molecular Mimicry To Target β-TrCP

mBio, 2015
NF-κB plays a critical role in the induction and maintenance of innate and adaptive immune transcriptional programs. An associated inhibitor of κB protein (IκB) regulates NF-κB activation and contains a degron motif (DSGΦxS) that undergoes ...
Marco Morelli, Allison F. Dennis, John T. Patton   +2 more
doaj   +1 more source

Maintaining Momentum for Rotavirus Immunization in Africa during the COVID-19 Era: Report of the 13th African Rotavirus Symposium

Vaccines, 2022
The 13th African Rotavirus Symposium was held as a virtual event hosted by the University of Nairobi, Kenya and The Kenya Paediatric Association on 3rd and 4th November 2021.
Frederick N. Were, Khuzwayo C. Jere, George E. Armah, M. Jeffrey Mphahlele, Jason M. Mwenda, A. Duncan Steele   +5 more
doaj   +1 more source

Effectiveness of rotavirus vaccination in prevention of hospital admissions for rotavirus gastroenteritis among young children in Belgium : case-control study [PDF]

, 2012
Objective : To evaluate the effectiveness of rotavirus vaccination among young children in Belgium. Design : Prospective case-control study. Setting : Random sample of 39 Belgian hospitals, February 2008 to June 2010.
A. Vergison, A.-S. Maernoudt, E. Heylen, H. Capiau, J. De Koster, J. Matthijnssens, J.-Y. Pircon, K. Van Herck, L. Verdonck, M. Azou, M. Raes, M. Soriano-Gabarro, M. Van Ranst, M. Verghote, M. Zeller, N. Meyer, null null, P. Van Damme, T. Braeckman   +18 more
core   +1 more source

Intracellular neutralisation of rotavirus by VP6-specific IgG

PLoS Pathogens, 2020
Rotavirus is a major cause of gastroenteritis in children, with infection typically inducing high levels of protective antibodies. Antibodies targeting the middle capsid protein VP6 are particularly abundant, and as VP6 is only exposed inside cells ...
S. Caddy, M. Vaysburd, M. Wing, Stian Foss, J. Andersen, K. O'connell, Keith Mayes, Katie Higginson, M. Iturriza-Gómara, U. Desselberger, L. James   +10 more
semanticscholar   +1 more source