Results 61 to 70 of about 149,034 (267)

Single-domain antibodies and their formatting to combat viral infections [PDF]

, 2018
Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies, De Vlieger, Dorien, Rossey, Iebe, Saelens, Xavier, Schepens, Bert   +4 more
core   +2 more sources

Cryo-EM map interpretation and protein model-building using iterative map segmentation. [PDF]

, 2020
A procedure for building protein chains into maps produced by single-particle electron cryo-microscopy (cryo-EM) is described. The procedure is similar to the way an experienced structural biologist might analyze a map, focusing first on secondary ...
Afonine PV, Kleywegt GJ, Liebschner D, Terwilliger TC, Terwilliger TC, Terwilliger TC, Terwilliger TC, Terwilliger TC, Terwilliger TC, Terwilliger TC   +9 more
core   +2 more sources

Epidemiological Survey of Rotaviruses Responsible for Infantile Diarrhea by the Immunomolecular Technique in Cotonou (Benin, West Africa)

International Journal of Microbiology, 2018
Rotavirus remains the main causative agent of gastroenteritis in young children, in countries that have not yet introduced the vaccine. Benin, in order to implement the WHO recommendations, projects to introduce the rotavirus vaccine in 2018 as part of ...
Jijoho Mischaël Michel Agbla, Annick Capo-Chichi, Alidéhou Jerrold Agbankpé, Tamègnon Victorien Dougnon, Anges William M. Yadouleton, Olivia Houngbégnon, Clément Glele-Kakai, George Enyimah Armah, Honoré Bankolé   +8 more
doaj   +1 more source

Clinical characteristics and complications of rotavirus gastroenteritis in children in east London: A retrospective case-control study. [PDF]

PLoS ONE, 2018
Rotavirus is the leading cause of acute gastroenteritis in children and is associated with neurological complications such as seizures and encephalopathy.
Konstantinos Karampatsas, Leanne Osborne, May-Li Seah, Cheuk Y W Tong, Andrew J Prendergast   +4 more
doaj   +1 more source

Rotavirus genotypes in children under five years hospitalized with diarrhea in low and middle-income countries: Results from the WHO-coordinated Global Rotavirus Surveillance Network.

PLOS Global Public Health, 2023
Rotavirus is the most common pathogen causing pediatric diarrhea and an important cause of morbidity and mortality in low- and middle-income countries.
Sebastien Antoni, Tomoka Nakamura, Adam L Cohen, Jason M Mwenda, Goitom Weldegebriel, Joseph N M Biey, Keith Shaba, Gloria Rey-Benito, Lucia Helena de Oliveira, Maria Tereza da Costa Oliveira, Claudia Ortiz, Amany Ghoniem, Kamal Fahmy, Hossam A Ashmony, Dovile Videbaek, Danni Daniels, Roberta Pastore, Simarjit Singh, Emmanuel Tondo, Jayantha B L Liyanage, Mohammed Sharifuzzaman, Varja Grabovac, Nyambat Batmunkh, Josephine Logronio, George Armah, Francis E Dennis, Mapaseka Seheri, Nonkululeko Magagula, Jeffrey Mphahlele, Jose Paulo G Leite, Irene T Araujo, Tulio M Fumian, Hanan El Mohammady, Galina Semeiko, Elena Samoilovich, Sidhartha Giri, Gagandeep Kang, Sarah Thomas, Julie Bines, Carl D Kirkwood, Na Liu, Deog-Yong Lee, Mirren Iturriza-Gomara, Nicola Anne Page, Mathew D Esona, M Leanne Ward, Courtnee N Wright, Slavica Mijatovic-Rustempasic, Jacqueline E Tate, Umesh D Parashar, Jon Gentsch, Michael D Bowen, Fatima Serhan   +52 more
doaj   +1 more source

Human milk oligosaccharides, milk microbiome and infant gut microbiome modulate neonatal rotavirus infection

Nature Communications, 2018
Neonatal rotavirus infections are predominantly asymptomatic. While an association with gastrointestinal symptoms has been described in some settings, factors influencing differences in clinical presentation are not well understood.
S. Ramani, C. Stewart, C. Stewart, D. Laucirica, N. Ajami, B. Robertson, C. Autran, Dhairyasheel Shinge, Sandya B Rani, Sasirekha Anandan, Liya Hu, J. Ferreon, K. Kuruvilla, J. Petrosino, B. Prasad, L. Bode, Gagandeep Kang, G. Kang, M. Estes   +18 more
semanticscholar   +1 more source

Rotavirus infections and their genotype distribution in Rwanda before and after the introduction of rotavirus vaccination

PLoS ONE, 2023
Rotavirus vaccination has reduced mortality and hospital admissions due to rotavirus diarrhoea, but its effect on rotavirus infections and the impact of rotavirus genotypes are still unclear. Real-time PCR was used to detect rotavirus and other pathogens
Jean-Claude Kabayiza, Staffan Nilsson, Maria Andersson   +2 more
doaj  

Physicochemical analysis of rotavirus segment 11 supports a 'modified panhandle' structure and not the predicted alternative tRNA-like structure (TRLS) [PDF]

, 2013
.Rotaviruses are a major cause of acute gastroenteritis, which is often fatal in infants. The viral genome consists of 11 double-stranded RNA segments, but little is known about their cis-acting sequences and structural elements.
A Heerschap, A L’Hernault, A Wilm, AE Simon, Andrew M. Lever, AR Gruber, BI Klasens, D Chen, D Chen, D Yue, D Yue, E Madore, E Matsuo, EC Hutchinson, Emily Manktelow, EV Puglisi, H Heus, HD Cho, J Jia, JC Kenyon, Jonathan Lever, JR Gog, JT Patton, Laura E. Easton, LE Easton, M Barro, M Estes, MA Tortorici, MW Friederich, N Figueroa, P Annamalai, Peter J. Lukavsky, PJ Lukavsky, R Giegé, R Giegé, RC Olsthoorn, S Nishimura, SC Chen, SH Bernhart, Subhajit Biswas, T Nagaike, TW Dreher, TW Dreher, TW Dreher, TW Dreher, Ulrich Desselberger, W Li, Wilson Li   +47 more
core   +1 more source

Lower Incidence Rate of Type 1 Diabetes after Receipt of the Rotavirus Vaccine in the United States, 2001–2017

Scientific Reports, 2019
We evaluated whether rotavirus vaccination is associated with the incidence of type 1 diabetes among children. We designed a cohort study of 1,474,535 infants in the United States from 2001–2017, using data from a nationwide health insurer.
M. Rogers, Tanima Basu, Catherine Kim
semanticscholar   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source