Results 61 to 70 of about 135,736 (315)

Repurposing rotavirus vaccines for intratumoral immunotherapy can overcome resistance to immune checkpoint blockade

Science Translational Medicine, 2019
Rotavirus vaccines have oncolytic properties and can overcome resistance to anti–PD-(L)1/CTLA-4 via RIG-I activation upon intratumoral administration.
T. Shekarian, Éva Sivadó, Anne-Catherine Jallas, S. Depil, J. Kielbassa, I. Janoueix-Lerosey, G. Hutter, N. Goutagny, C. Bergeron, A. Viari, S. Valsesia-Wittmann, C. Caux, A. Marabelle   +12 more
semanticscholar   +1 more source

Estimating the global impact of rotavirus vaccines on child mortality

International Journal of Infectious Diseases, 2023
Objectives: We estimated the global impact of rotavirus vaccines on deaths among children under five years old by year. Methods: We used a proportionate outcomes model with a finely disaggregated age structure to estimate rotavirus deaths prevented by ...
Andrew Clark, Sarwat Mahmud, Frederic Debellut, Clint Pecenka, Mark Jit, Jamie Perin, Jacqueline Tate, Heidi M. Soeters, Robert E. Black, Mathuram Santosham, Colin Sanderson   +10 more
doaj  

Characterization of a Second Bovine Rotavirus Serotype [PDF]

, 1987
Bovine rotavirus (BRV) V 1005 was characterized by two-way cross-neutralization tests as a second serotype of BRV. Virions and inner shell particles of 65 nm and 55 nm diameter respectively, and empty capsids of 65 nm and 55 nm diameter were separated by
Büssow, Harald, Eichhorn, Werner, Fryder, V., Marc-Martin, S., Sidoti, J.   +4 more
core   +1 more source

Human neonatal rotavirus vaccine (RV3-BB) targets rotavirus from birth

New England Journal of Medicine, 2018
Background A strategy of administering a neonatal rotavirus vaccine at birth to target early prevention of rotavirus gastroenteritis may address some of the barriers to global implementation of a rotavirus vaccine.
J. Bines, Jarir At Thobari, C. D. Satria, A. Handley, Emma Watts, D. Cowley, H. Nirwati, J. Ackland, Jane Standish, F. Justice, Gabrielle Byars, Katherine J. Lee, G. Barnes, N. S. Bachtiar, Ajeng Viska Icanervilia, Karen Boniface, N. Bogdanovic-Sakran, Daniel Pavlic, R. Bishop, C. Kirkwood, J. Buttery, Y. Soenarto   +21 more
semanticscholar   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Zinc Alleviates Gut Barrier Dysfunction by Promoting the Methylation of AKT

Advanced Science, EarlyView.
Zinc activates the ZNG1‐METAP1 complex to elevate intracellular SAM levels, which promotes PRMT5‐mediated symmetrical dimethylation of AKT at R391 and R15. This epigenetic modification facilitates AKT membrane translocation and mTORC2 activation, thereby enhancing epithelial proliferation and gut barrier integrity.
Chuanjiang Cai, Yining Zheng, Bo Sun, Guoyan Wang, Pengfei Li, Huijun Geng, Rongnuo Li, Miaomiao Zhu, Yuanyuan Zhu, Dingping Feng, Lei Chen, Guiyan Chu, Lu Deng, Shiyan Qiao   +13 more
wiley   +1 more source

Rotavirus gastroenteritis in Indian children < 5 years hospitalized for diarrhoea, 2012 to 2016

BMC Public Health, 2019
BackgroundIn 2016, the Government of India introduced the oral rotavirus vaccine (ROTAVAC, Bharat Biotech, India) in 4 states of India as part of the Universal Immunization Programme, and expanded to 5 more states in 2017. We report four years of data on
S. Giri, N. Nair, A. Mathew, B. Manohar, A. Simon, T. Singh, S. Suresh Kumar, M. Mathew, S. Babji, R. Arora, C. G. Girish Kumar, S. Venkatasubramanian, S. Mehendale, M. Gupte, G. Kang   +14 more
semanticscholar   +1 more source

Rotavirus genotypes in children under five years hospitalized with diarrhea in low and middle-income countries: Results from the WHO-coordinated Global Rotavirus Surveillance Network.

PLOS Global Public Health, 2023
Rotavirus is the most common pathogen causing pediatric diarrhea and an important cause of morbidity and mortality in low- and middle-income countries.
Sebastien Antoni, Tomoka Nakamura, Adam L Cohen, Jason M Mwenda, Goitom Weldegebriel, Joseph N M Biey, Keith Shaba, Gloria Rey-Benito, Lucia Helena de Oliveira, Maria Tereza da Costa Oliveira, Claudia Ortiz, Amany Ghoniem, Kamal Fahmy, Hossam A Ashmony, Dovile Videbaek, Danni Daniels, Roberta Pastore, Simarjit Singh, Emmanuel Tondo, Jayantha B L Liyanage, Mohammed Sharifuzzaman, Varja Grabovac, Nyambat Batmunkh, Josephine Logronio, George Armah, Francis E Dennis, Mapaseka Seheri, Nonkululeko Magagula, Jeffrey Mphahlele, Jose Paulo G Leite, Irene T Araujo, Tulio M Fumian, Hanan El Mohammady, Galina Semeiko, Elena Samoilovich, Sidhartha Giri, Gagandeep Kang, Sarah Thomas, Julie Bines, Carl D Kirkwood, Na Liu, Deog-Yong Lee, Mirren Iturriza-Gomara, Nicola Anne Page, Mathew D Esona, M Leanne Ward, Courtnee N Wright, Slavica Mijatovic-Rustempasic, Jacqueline E Tate, Umesh D Parashar, Jon Gentsch, Michael D Bowen, Fatima Serhan   +52 more
doaj   +1 more source

Detection of Human Group a and C Rotaviruses in Pediatric Patients with Acute Gastroenteritis by Real TIME RT-PCR Assay: a Preliminary Study [PDF]

, 2010
Rotavirus causes 25–55% of all hospital admissions for diarrhea and approximately 611.000 deaths every year in developing countries. Clinically, it is not possible to recognize the diarrhea caused by rotavirus and other infections.
Dewi, B. E. (Beti), Dwipoerwantoro, P. G. (Pramita), Harahap, E. D. (Elisabeth), Yasmon, A. (Andi)   +3 more
core  

A Case of Henoch-Schonlein Purpura Associated with Rotavirus Infection in an Elderly Asian Male and Review of the Literature. [PDF]

, 2017
BACKGROUND Henoch-Schönlein purpura (HSP), a small vessel vasculitis mediated by deposition of immune-complexes containing IgA in the skin, gut, and glomeruli, often presents with abdominal pain, purpuric rash in the lower extremities and buttocks, joint
Adderley, Adderley, Bender, Epstein, Homberg, Kim, Mongillo, Page, Raja Beharelle, Ridding, Saur, Szaflarski, Wade, Zaccolo   +13 more
core   +2 more sources