Results 51 to 60 of about 40,062 (227)

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Epidemiological aspects, diagnosis and prevention of rotaviral infection

One Health & Risk Management, 2021
Introduction. Diarrheal diseases are the leading cause of childhood mortality globally as well as in Republic Moldova. Rotavirus has been recognized as the most common cause of infectious gastroenteritis in infants and young children.
Ahmad Adnan SALTI
doaj  

Post-vaccinated asymptomatic rotavirus infections: A community profile study of children in Surabaya, Indonesia

Journal of Infection and Public Health, 2019
Background: Rotavirus gastroenteritis accounts for significant childhood morbidity and mortality worldwide. Vaccination using RotarixTM (GSK) and RotaTeq® (Merck) was introduced due to the tremendous disease burden.
Emily Gunawan, Takako Utsumi, Rury M. Wahyuni, Zayyin Dinana, Subijanto M. Sudarmo, Ikuo Shoji, Soetjipto, Maria I. Lusida   +7 more
doaj   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Rotavirus and adenovirus infections in children with acute gastroenteritis after introducing the Rotasiil® vaccine in Kisangani, Democratic Republic of the Congo.

PLoS ONE
BackgroundAlthough rotavirus vaccination has reduced the global burden of the virus, morbidity and mortality from rotavirus infection remain high in Sub-Saharan Africa.
Didier Gbebangi Manzemu, Jean Pierre Alworong'a Opara, Emmanuel Tebandite Kasai, Mupenzi Mumbere, Véronique Muyobela Kampunzu, Bibi Batoko Likele, Naura Apio Uvoya, Hortense Malikidogo Vanzwa, Gaspard Mande Bukaka, Falay Sadiki Dady, Nestor Ngbonda Dauly, Laurent Belec, Serge Tonen-Wolyec   +12 more
doaj   +1 more source

Epidemic of Rotavirus Infection in Neonatal Intensive Care Unit

Forbes Tıp Dergisi, 2021
Objective: To evaluate rotavirus epidemic in a neonatal intensive care unit (NICU) and to contribute to the literature on rotavirus outbreak in the newborn. Methods: An epidemic of rotavirus infection was seen in the NICU of our hospital in September 12,
Funda Yavanoğlu Atay, Ömer Güran, Leyla Bilgin   +2 more
doaj   +1 more source

Trends in hospitalizations for vaccine‐preventable diseases in the United States from 2014 to 2024

Journal of Hospital Medicine, EarlyView.
Abstract Background and Objectives Vaccination rates have declined in recent years, resulting in outbreaks of vaccine‐preventable diseases (VPDs) among children. We aimed to evaluate VPD hospitalization rates from 2014 to 2024 and to report associated trends in outcomes including intensive care utilization, mortality, readmissions, and costs.
Nathan M. Money, Erin Sullivan, Hannah Rector, Corrie E. McDaniel, Jessica L. Markham, Mersine A. Bryan   +5 more
wiley   +1 more source

Wastewater concentrations of rotavirus RNA are associated with infection and vaccination metrics in the USA

npj Viruses
Surveillance of rotavirus infections remains critical because vaccines are underutilized in the USA. Using wastewater solids measurements of rotavirus RNA collected over one year from 185 wastewater treatment plants (WWTPs) in the USA, we inferred ...
Elana M. G. Chan, Alessandro Zulli, Alexandria B. Boehm   +2 more
doaj   +1 more source

Etiological surveillance of viral diarrhea from 2017 to 2019 in Zhangzhou city, Fujian province, China

Frontiers in Public Health
BackgroundViral diarrhea is one of the major causes of morbidity and mortality in children. This study aimed to conduct etiological surveillance of viral diarrhea in Zhangzhou city, Fujian province, China, from 2017 to 2019 to identify the prevalence ...
Yueli Guo, Weide Chen, Guowei Wang, Huicong Yang, Qiaoling Zhou, Chunbin Zhang, Yuanjun Zeng   +6 more
doaj   +1 more source

Detection and Characterization of Rotavirus G and P Types from Children Participating in a Rotavirus Vaccine Trial in Belém, Brazil

Memorias do Instituto Oswaldo Cruz, 2002
This study sought the characterization of rotaviruses in a trial with a tetravalent rhesus-human rotavirus vaccine in Belém, Brazil in children who received three doses of vaccine or placebo in the 1st, 3rd and 5th months of life.
JDP Mascarenhas, AC Linhares, YB Gabbay, JPG Leite   +3 more
doaj   +1 more source