Results 61 to 70 of about 58,921 (216)

Expression of Ifnlr1 on intestinal epithelial cells is critical to the antiviral effects of IFN-lambda against norovirus and reovirus [PDF]

, 2017
Lambda interferon (IFN-λ) has potent antiviral effects against multiple enteric viral pathogens, including norovirus and rotavirus, in both preventing and curing infection. Because the intestine includes a diverse array of cell types, however, the cell(s)
Baldridge, Megan T, Brown, Judy J, Dermody, Terence S, Lee, Sanghyun, McAllister, Nicole, Nice, Timothy J, Urbanek, Kelly, Virgin, Herbert W   +7 more
core   +2 more sources

Treosulfan–fludarabine conditioning in infants with severe combined immunodeficiencies: Extended study of the UK paediatric treosulfan study

British Journal of Haematology, EarlyView.
Summary Allogeneic haematopoietic stem cell transplantation (HSCT) is a curative therapy for severe combined immunodeficiency (SCID). Conditioning improves donor engraftment and freedom from immunoglobulin replacement (IgR) but increases the risks of acute and late toxicity. Treosulfan, a reduced toxicity alkylating agent, has emerged as an alternative
Su Han Lum, Sinéad Greener, Irum Latif Memon, Persis Amrolia, Zohreh Nademi, Robert Chiesa, Juliana Silva, Helen Young, Stephen Owens, Eleri Williams, Khuen Foong Ng, Terry Flood, Andrew R Gennery, Sophie Hambleton, Kanchan Rao, Mary Slatter   +15 more
wiley   +1 more source

Single-domain antibodies and their formatting to combat viral infections [PDF]

, 2018
Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies, De Vlieger, Dorien, Rossey, Iebe, Saelens, Xavier, Schepens, Bert   +4 more
core   +2 more sources

Long‐term outcomes of gastric bypass surgery in two Lusitano foals: Contemporary evidence for surgical decision‐making

Equine Veterinary Education, EarlyView.
Summary Gastric outflow obstruction (GOO) occasionally requires surgical intervention in foals when medical management fails. Current literature lacks consensus on several surgical decisions, with most comprehensive reports dating back over a decade. Critical aspects—including jejunal loop orientation and necessity of jejunojejunostomy—remain debated ...
P. Fernández Hernández, M. Valero González, F. Bulnes Jiménez, N. Venegas Chávez, B. Fuentes Romero, M. Iglesias García, J. Jiménez Fragoso, M. Martín Cuervo, L. J. Ezquerra Calvo   +8 more
wiley   +1 more source

Trends and measurement of HIV prevalence in northern Malawi.

, 2003
BACKGROUND: Most data on HIV prevalence in Malawi come from antenatal clinic (ANC) surveillance and are, therefore, subject to bias. OBJECTIVES: HIV prevalence and risk factors were measured using population-based data to assess the accuracy of ANC ...
Crampin, Amelia C, Fine, Paul E, Glynn, Judith R, Mwaungulu, Frank D, Ngwira, Bagrey M, Pönnighaus, Jörg M, Warndorff, David K   +6 more
core   +1 more source

Simultaneous modification of Thermotoga maritima encapsulin subunits to produce multivalent nanoparticle vaccines for non‐typhoidal Salmonella enterica

The FEBS Journal, EarlyView.
This study investigates the modularity of encapsulin—a protein nanoparticle—by simultaneously inserting up to four distinct Salmonella epitopes within the encapsulin subunit. The encapsulin variants were transiently expressed in plants where they assembled into nanoparticles; however, their accumulation and stability varied depending on the ...
Carly A. Charron, Angelo Kaldis, Shabnam Shamriz, Moussa S. Diarra, Christopher P. Garnham, Rima Menassa   +5 more
wiley   +1 more source

Rotavirus symptomatic infection among unvaccinated and vaccinated children in Valencia, Spain

BMC Infectious Diseases, 2019
Background Human group A rotavirus is the leading cause of severe acute gastroenteritis in young children worldwide. Immunization programs have reduced the disease burden in many countries. Vaccination coverage in the Autonomous Region of Valencia, Spain,
Raúl Pérez-Ortín, Cristina Santiso-Bellón, Susana Vila-Vicent, Noelia Carmona-Vicente, Jesús Rodríguez-Díaz, Javier Buesa   +5 more
doaj   +1 more source

Antigenic and biochemical characterization of bovine rotavirus V1005, a new member of rotavirus serotype 10 [PDF]

, 1990
Bovine rotavirus (BRV) V1005 is serologically distinct from rotavirus serotypes 1, 2, 3, 4, 5, 6, 8 and 9. BRV V1005 showed cross-reactions with BRV B223, the American prototype of serotype 10 rotavirus, and with BRV E4049, a British serotype 10 isolate.
Bruttin, Anne, Büssow, Harald, Eichhorn, Werner, Fitzgerald, Tracey, Gerhards, Roswitha, Snodgrass, David   +5 more
core   +1 more source

Achieving Cancer Prevention Equity: A Policy Analysis of American Cancer Society HPV Vaccination Guidelines

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To examine the American Cancer Society's HPV vaccination guidelines through a nursing policy analysis framework, assessing justice and equity outcomes in cancer prevention policy implementation. Background Human papillomavirus vaccination remains critical for cancer prevention, yet persistent health disparities undermine equity goals ...
Grace K. Kyei, Evans K. Kyei, Rockson Ansong   +2 more
wiley   +1 more source

Effectiveness of rotavirus vaccination in prevention of hospital admissions for rotavirus gastroenteritis among young children in Belgium : case-control study [PDF]

, 2012
Objective : To evaluate the effectiveness of rotavirus vaccination among young children in Belgium. Design : Prospective case-control study. Setting : Random sample of 39 Belgian hospitals, February 2008 to June 2010.
A. Vergison, A.-S. Maernoudt, E. Heylen, H. Capiau, J. De Koster, J. Matthijnssens, J.-Y. Pircon, K. Van Herck, L. Verdonck, M. Azou, M. Raes, M. Soriano-Gabarro, M. Van Ranst, M. Verghote, M. Zeller, N. Meyer, null null, P. Van Damme, T. Braeckman   +18 more
core   +1 more source