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Rotavirus vaccines

Scandinavian Journal of Infectious Diseases, 2008
Two live attenuated oral rotavirus vaccines were licensed in 2006 for prevention of severe acute gastroenteritis in children: Rotarix (GSK), a human rotavirus vaccine with G1P[8] serotype characteristics and RotaTeq (Merck), a bovine-human reassortant vaccine expressing human G1-4 and P[8] antigens.
openaire   +3 more sources

The rotavirus vaccine

Journal of Clinical Virology, 1998
Rotavirus gastroenteritis is an important cause of morbidity and mortality worldwide.To review the biology, immunology, and virology of rotavirus infections and describe the efforts towards the construction of vaccines using human and animal rotaviruses.A review of the literature and provision of the author's understanding and speculation of ...
openaire   +2 more sources

Rotavirus Vaccines and Vaccination Potential

1994
The development of a successful rotavirus vaccine is a complex problem. Our review of rotavirus vaccine development shows that many challenges remain, and priorities for future studies need to be established. For example, the evaluation of administration of a vaccine with OPV or breast milk might receive less emphasis until a vaccine is made that shows
M E, Conner, D O, Matson, M K, Estes
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Update on Rotavirus Vaccines

The Pediatric Infectious Disease Journal, 2005
Rotavirus was discovered in 1973, and 10 years later the first report of a rotavirus vaccine clinical trial appeared. This update reviews the epidemiology of rotavirus infections, assesses past and current vaccines and presents ideas for implementation of vaccination programs in developed and developing countries.
Joseph S, Bresee   +5 more
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Rotavirus vaccines—An update

Vaccine, 2005
Rotavirus infection is the most common cause of severe diarrhea disease in infants and young children worldwide and has a major global impact on childhood morbidity and mortality. Vaccination is the only control measure likely to have a significant impact on the incidence of severe dehydrating rotavirus disease.Rotavirus disease prevention efforts ...
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Diversity of rotavirus strains circulating in children under five years of age who presented with acute gastroenteritis before and after rotavirus vaccine introduction, University Teaching Hospital, Lusaka, Zambia, 2008–2015

Vaccine, 2018
Background: Following the introduction of rotavirus vaccine into the routine immunization schedule, the burden of rotavirus disease has significantly reduced in Zambia.
Simwaka Jc   +10 more
semanticscholar   +1 more source

Rotavirus Vaccine (RotaTeq??)

Pediatric Drugs, 2006
RotaTeq is a live, oral, pentavalent human-bovine reassortant rotavirus vaccine approved for use in the prevention of G1-G4 rotavirus gastroenteritis in infants and children. Rotavirus vaccine demonstrated good immunogenicity in healthy infants. Three oral doses of rotavirus vaccine had a protective efficacy against G1-G4 rotavirus gastroenteritis of ...
openaire   +2 more sources

Tetravalent Rotavirus Vaccine

Annals of Pharmacotherapy, 1999
OBJECTIVE: To review the clinical efficacy, safety, and pharmacoeconomic data about the use of rhesus–human reassortant rotavirus tetravalent vaccine (RRV-TV) in infants and children. DATA SOURCES: A MEDLINE search (January 1990 ...
T L, Wandstrat   +3 more
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Intussusception and rotavirus vaccines

Vaccine, 2006
The association between the first oral rotavirus vaccine to be licensed in the U.S. (Rotashield) and intussusception has presented a major challenge to the effort to reduce the global burden related to rotavirus infection. Although the risk of developing intussusception following immunization with Rotashield is low, debate continues about the ...
openaire   +2 more sources

Viral Etiology of Acute Gastroenteritis in <2-Year-Old US Children in the Post-Rotavirus Vaccine Era.

Journal of the Pediatric Infectious Diseases Society, 2018
Background The rotavirus disease burden has declined substantially since rotavirus vaccine was introduced in the United States in 2006. The aim of this study was to determine the viral etiology of acute gastroenteritis (AGE) in US children aged
Ferdaus Hassan   +23 more
semanticscholar   +1 more source

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