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ChemistryOpen, Volume 13, Issue 1, January 2024.Rotenone derivatives were synthesized through modifications of the carbonyl group and their antiproliferative activities were evaluated against various cancer cell lines (MCF‐7, A549, and HCT116). The physicochemical properties and drug‐likeness of the derivatives were evaluated using the SwissADME webtool.
Rajelle D. Hernandez +4 more
wiley +1 more source
Nonprenylated Rotenoids, a New Class of Potent Breast Cancer Resistance Protein Inhibitors [PDF]
, 2016 Two rotenoids isolated from Boerhaavia diffusa (Nyctaginaceae), boeravinones G (1) and H (2), have been found to potently inhibit the drug efflux activity of breast cancer resistance protein (BCRP/ABCG2), a multidrug transporter responsible for cancer ...
Sira Macalou (2495500) +6 more
core +1 more source
STUDIES TOWARD TOTAL SYNTHESIS OF (-)-DEGUELIN [PDF]
, 2013 Deguelin, as a rotenoid, has emerged as an attractive pharmacophore for chemprevention due to its effectiveness for both in vitro and in vivo models.
Li, Bao
core
Rotenoids from Boerhaavia diffusa as Potential Anti-inflammatory Agents [PDF]
, 2016 Five new (2, 3, 5, 7, and 9) and four known rotenoids (1, 4, 6, and 8) were isolated from a methanol extract of Boerhaavia diffusa roots. The structures of the new rotenoids were elucidated by spectroscopic data interpretation. The 70% ethanol extract, a
Amit Srivastava (23227) +5 more
core +1 more source
Expedient syntheses of the rotenoid and thiorotenoid systems [PDF]
, 1994 A simple four-step synthesis of a 6,6-disubstituted 6a,12a-dihydro-6H,12H-[1]benzopyrano[3,4,-b]-[1]benzopyran-12-one 6 from a chroman-4-one 3 is described.
Gabbutt, Christopher D. +2 more
core +1 more source
Isoflavones and Rotenoids from the Leaves of Millettia brandisiana
Chemical and Pharmaceutical Bulletin, 2008 A new isoflavone, 4'-gamma,gamma-dimethylallyloxy-5,7,2',5'-tetramethoxyisoflavone, brandisianin A (1), was isolated from the leaves of Millettia brandisiana, along with one synthetically known isoflavone, 7,4'-di-O-prenylgenistein (2) and twelve known compounds. The structures were elucidated on the basis of extensive spectroscopic analysis.
Pancharoen, Orasa +3 more
openaire +3 more sources
Mechanistic investigation on compounds from Amorpha fruticosa L. targeting acetylcholinesterase [PDF]
Acetylcholinesterase (AChE) is the enzyme targeted by drugs used for the symptomatic treatment of cognitive decline associated with Alzheimer’s disease. While in vitro data suggest the AChE inhibitory potential of A.
Durosini, Edoardo +4 more
core +1 more source
Antiplasmodial and larvicidal flavonoids from Derris trifoliate
Bulletin of the Chemical Society of Ethiopia, 2009 From the dichloromethane-methanol (1:1) extract of the seed pods of Derris trifoliata, a new flavanone derivative (S)-lupinifolin 4´-methyl ether was isolated. In addition, the known flavonoids lupinifolin and rotenone were identified.
Abiy Yenesew +9 more
doaj
Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway
Cancer Management and Research, 2018 Liubo Chen,1,2,* Kai Jiang,1,2,* Haiyan Chen,1,3,* Yang Tang,1,2 Xinyi Zhou,1,2 Yinuo Tan,1,4 Ying Yuan,1,4 Qian Xiao,1,2 Kefeng Ding1,2 1Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key ...
Chen L +8 more
doaj
New Class of Tyrosinase Inhibitors, Rotenoids, from Amorpha fruticosa. [PDF]
ACS Omega, 2023 Moon SW +5 more
europepmc +1 more source