Results 1 to 10 of about 83 (81)
Efficacy of Deguelin and Silibinin on Benzo(a)pyrene-Induced Lung Tumorigenesis in A/J Mice
Neoplasia, 2005 We evaluated deguelin and silibinin in A/J mice treated with the tobacco-specific carcinogen benzo(a)pyrene (BP) for their ability to inhibit pulmonary adenoma formation and growth. Animals were treated with either deguelin (5.0 or 10.0 mg/kg body weight,
Ming You
exaly +3 more sources
Molecules, 2014 Osteosarcoma is the most common malignant primary bone tumor in children and young adults and lung metastasis is the main cause of death in those patients. Deguelin, a naturally occurring rotenoid, is known to be an Akt inhibitor and to exhibit cytotoxic
Hung-Sheng Shang +2 more
exaly +3 more sources
Toxins, 2022 Botanical pesticides have received increasing attention for sustainable control of insect pests. Plants from the genus Tephrosia are known to produce rotenone and deguelin.
Peiwen Zhang +5 more
doaj +1 more source
BAD, a Proapoptotic Protein, Escapes ERK/RSK Phosphorylation in Deguelin and siRNA-Treated HeLa Cells. [PDF]
PLoS ONE, 2016 This study has been undertaken to explore the therapeutic effects of deguelin and specific siRNAs in HeLa cells. The data provided clearly show the silencing of ERK 1/2 with siRNAs and inhibition of ERK1/2 with deguelin treatment in HeLa cells ...
Samra Hafeez +15 more
doaj +1 more source
Deguelin induces both apoptosis and autophagy in cultured head and neck squamous cell carcinoma cells. [PDF]
PLoS ONE, 2013 Head and neck squamous cell carcinoma (HNSCC) represents more than 5% of all cancers diagnosed annually in United States and around the world. Despite advances in the management of patients with this disease, the survival has not been significantly ...
Yan-li Yang +6 more
doaj +1 more source
Mitochondrial DNA mutations in ageing and cancer
Molecular Oncology, Volume 16, Issue 18, Page 3276-3294, September 2022., 2022 Mitochondrial DNA mutations are a common feature of ageing tissues and a number of human cancers. They can affect essential mitochondrial functions such as oxidative phosphorylation, redox balance, apoptosis, and numerous biosynthetic pathways. These are important mechanisms which reportedly impact tumour growth, though data are often contradictory ...
Anna L. M. Smith +2 more
wiley +1 more source
Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model. [PDF]
PLoS ONE, 2016 B-cell chronic lymphocytic leukemia (CLL) remains an incurable disease, and despite the improvement achieved by therapeutic regimes developed over the last years still a subset of patients face a rather poor prognosis and will eventually relapse and ...
Nerea Rebolleda +9 more
doaj +1 more source
A review on invasive false indigo bush (Amorpha fruticosa L.): Nuisance plant with multiple benefits
Ecology and Evolution, Volume 12, Issue 9, September 2022., 2022 Amorpha fruticosa L. represents an invasive plant causing a nuisance and degrading native biodiversity on a variety of wet and mesic habitats throughout the Northern Hemisphere. On the other hand, the plant species possesses numerous beneficial applications including phytochemical and biocoenotic uses, as well as ecosystem services.
Jasna Grabić +4 more
wiley +1 more source
ChemistryOpen, Volume 11, Issue 5, May 2022., 2022 Ligands selectively targeting DNA G‐quadruplexes (G4s) represent valuable targeted anticancer drugs. Aiming at speeding the identification of G4‐targeting ligands, the affinity chromatography‐based assay named G‐quadruplex on Oligo Affinity Support (G4‐OAS) was developed, by synthesizing G4‐forming sequences on commercial polystyrene OAS.
Chiara Platella +4 more
wiley +1 more source
Physiologia Plantarum, Volume 174, Issue 2, March/April 2022., 2022 Abstract Seed inoculation with beneficial microorganisms has gained importance as it has been proven to show biostimulant activity in plants, especially in terms of abiotic/biotic stress tolerance and plant growth promotion, representing a sustainable way to ensure yield stability under low input sustainable agriculture. Nevertheless, limited knowledge
Paola Ganugi +9 more
wiley +1 more source