Results 21 to 30 of about 747 (158)

Deguelin Attenuates Non-Small-Cell Lung Cancer Cell Metastasis by Upregulating PTEN/KLF4/EMT Signaling Pathway. [PDF]

Dis Markers, 2022
Non‐small‐cell lung cancer (NSCLC) is the most common lung cancer and a major cause of cancer mortality worldwide. Deguelin plays a vital inhibitory role in NSCLC initiation and development. However, the downstream mechanism of deguelin‐suppressed metastasis of NSCLC cells is still not completely understood.
Lu G, Yao Y, Zhang X, Cui D, Zhou J.
europepmc   +2 more sources

Novel insights into immunopathogenesis and crucial biomarkers between primary open-angle glaucoma and systemic lupus erythematosus. [PDF]

IMetaOmics
This study revealed a novel correlation between systemic lupus erythematosus (SLE) and primary open‐angle glaucoma (POAG) through comprehensive bioinformatics analysis and experimentation, identifying biomarkers and immunopathogenesis for future research and treatment of SLE‐related POAG.
Liu Y, You M, Zeng Z, Wang J, Rong R, Xia X.   +5 more
europepmc   +2 more sources

Amelioration of an undesired action of deguelin [PDF]

Toxicon, 2013
The pharmaceutical world has greatly benefited from the well-characterized structure-function relationships of toxins with endogenous biomolecules, such as ion-channels, receptors, and signaling molecules. Thus, therapeutics derived from toxins have been aggressively pursued.
Julie A, Vrana, Nathan, Boggs, Holly N, Currie, Jonathan, Boyd   +3 more
openaire   +2 more sources

Mitochondrial DNA mutations in ageing and cancer

Molecular Oncology, Volume 16, Issue 18, Page 3276-3294, September 2022., 2022
Mitochondrial DNA mutations are a common feature of ageing tissues and a number of human cancers. They can affect essential mitochondrial functions such as oxidative phosphorylation, redox balance, apoptosis, and numerous biosynthetic pathways. These are important mechanisms which reportedly impact tumour growth, though data are often contradictory ...
Anna L. M. Smith, Julia C. Whitehall, Laura C. Greaves   +2 more
wiley   +1 more source

A review on invasive false indigo bush (Amorpha fruticosa L.): Nuisance plant with multiple benefits

Ecology and Evolution, Volume 12, Issue 9, September 2022., 2022
Amorpha fruticosa L. represents an invasive plant causing a nuisance and degrading native biodiversity on a variety of wet and mesic habitats throughout the Northern Hemisphere. On the other hand, the plant species possesses numerous beneficial applications including phytochemical and biocoenotic uses, as well as ecosystem services.
Jasna Grabić, Branka Ljevnaić‐Mašić, Ai Zhan, Pavel Benka, Hermann Heilmeier   +4 more
wiley   +1 more source

Affinity Chromatography‐Based Assays for the Screening of Potential Ligands Selective for G‐Quadruplex Structures

ChemistryOpen, Volume 11, Issue 5, May 2022., 2022
Ligands selectively targeting DNA G‐quadruplexes (G4s) represent valuable targeted anticancer drugs. Aiming at speeding the identification of G4‐targeting ligands, the affinity chromatography‐based assay named G‐quadruplex on Oligo Affinity Support (G4‐OAS) was developed, by synthesizing G4‐forming sequences on commercial polystyrene OAS.
Chiara Platella, Ettore Napolitano, Claudia Riccardi, Domenica Musumeci, Daniela Montesarchio   +4 more
wiley   +1 more source

Nitrogen use efficiency, rhizosphere bacterial community, and root metabolome reprogramming due to maize seed treatment with microbial biostimulants

Physiologia Plantarum, Volume 174, Issue 2, March/April 2022., 2022
Abstract Seed inoculation with beneficial microorganisms has gained importance as it has been proven to show biostimulant activity in plants, especially in terms of abiotic/biotic stress tolerance and plant growth promotion, representing a sustainable way to ensure yield stability under low input sustainable agriculture. Nevertheless, limited knowledge
Paola Ganugi, Andrea Fiorini, Federico Ardenti, Tito Caffi, Paolo Bonini, Eren Taskin, Edoardo Puglisi, Vincenzo Tabaglio, Marco Trevisan, Luigi Lucini   +9 more
wiley   +1 more source

Oxidative stress parameters and keap 1 variants in T2DM: Association with T2DM, diabetic neuropathy, diabetic retinopathy, and obesity

Journal of Clinical Laboratory Analysis, Volume 36, Issue 1, January 2022., 2022
Studying 400 T2DM patients without complication indicated: In T2DM patients without complication, the GPx and TAC levels decreased and the MDA level elevated. T2DM with neuropathy had lower levels of GSH, GPx, and TAC and higher levels of TOS, MDA, and OSI and a higher frequency of Keap1 AA genotype.
Farnaz Khalili, Asad Vaisi‐Raygani, Ebrahim Shakiba, Maryam Kohsari, Maryam Dehbani, Rozita Naseri, Soheila Asadi, Ziba Rahimi, Mehrali Rahimi, Zohreh Rahimi   +9 more
wiley   +1 more source

Guidance on the use of read-across for chemical safety assessment in food and feed. [PDF]

EFSA J
Abstract Read‐across is a method used in chemical risk assessment to predict the toxicological properties of a target substance by using data from structurally and mechanistically similar substances, known as source substances. EFSA's Scientific Committee has developed an approach for using read‐across in food and feed risk assessment.
EFSA Scientific Committee, Bennekou SH, Allende A, Bearth A, Casacuberta J, Castle L, Coja T, Crépet A, Halldorsson T, Halldorsson T, Hoogenboom LR, Jokelainen P, Knutsen H, Koutsoumanis K, Lambré C, Nielsen S, Turck D, Civera AV, Villa RE, Zorn H, Benfenati E, Benigni R, Chaudhry Q, Farcal L, Kass G, Nathanail A, Paini A, Serafimova R.   +27 more
europepmc   +2 more sources

Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Cancer is a complex disease with several distinct characteristics, referred to as “cancer markers” one of which is metabolic reprogramming, which is a common feature that drives cancer progression. Over the last ten years, researchers have focused on the reprogramming of glucose metabolism in cancer.
Gui-hua Lai, Fei Wang, Duo-rui Nie, Shu-jun Lei, Zhuo-jun Wu, Jian-xiong Cao, Lan-lan Tang, Maria Grazia Ferraro   +7 more
wiley   +1 more source