Acta PharmaceuticaDeguelin exhibits antiproliferative activity against various cancer cell types. Previous studies have reported that deguelin exhibits pro-apoptotic activity against human cancer cells. The current study aimed at further elaborating the anticancer effects
Sun Kening +4 more
doaj +4 more sources
Inhibition of Autophagy by Deguelin Sensitizes Pancreatic Cancer Cells to Doxorubicin [PDF]
International Journal of Molecular Sciences, 2016 Pancreatic cancer is the fourth most common cause of cancer mortality worldwide. Furthermore, patients with pancreatic cancer experience limited benefit from current chemotherapeutic approaches because of drug resistance. Therefore, an effective therapeutic strategy for patients with pancreatic cancer is urgently required.
Xiao-Dong Xu +12 more
openaire +4 more sources
Transglutaminase 3 regulates cutaneous squamous carcinoma differentiation and inhibits progression via PI3K-AKT signaling pathway-mediated Keratin 14 degradation [PDF]
Cell Death and DiseaseCutaneous squamous carcinoma is the second most common epithelial malignancy, associated with significant morbidity, mortality, and economic burden. However, the mechanisms underlying cSCC remain poorly understood.
Kaili Zhou +10 more
doaj +2 more sources
Inhibitory Effects of B‑, C‑, and E‑Ring-Truncated Deguelin Derivatives Against A549, HCT116, and MCF‑7 Cancer Cells [PDF]
ACS Omega, 2023 John Alfon P. Francisco +1 more
doaj +2 more sources
Deguelin Attenuates Non-Small-Cell Lung Cancer Cell Metastasis by Upregulating PTEN/KLF4/EMT Signaling Pathway. [PDF]
Dis Markers, 2022 Non‐small‐cell lung cancer (NSCLC) is the most common lung cancer and a major cause of cancer mortality worldwide. Deguelin plays a vital inhibitory role in NSCLC initiation and development. However, the downstream mechanism of deguelin‐suppressed metastasis of NSCLC cells is still not completely understood.
Lu G, Yao Y, Zhang X, Cui D, Zhou J.
europepmc +2 more sources
Involvement of SRC-3 in deguelin-induced apoptosis in Jurkat cells
International Journal of Hematology, 2009 The aim of the study was to investigate the anticancer effects and the molecular mechanisms of deguelin on Jurkat cells. Cell viability was assessed by MTT assay. Terminal deoxynucleotide transferase-mediated dUTP nick end labeling (TUNEL) assay and transmission electron microscopy were used to detect cell apoptosis.
Shu, W-X +4 more
openaire +5 more sources
[Effect of deguelin on expression of nup98 in K562 cells].
Zhongguo shi yan xue ye xue za zhi, 2007 The study was purposed to investigate the effect of deguelin on expression of nucleoporin 98 (nup98) in leukemia K562 cells. MTT assay was used to assess the effects of deguelin on cell proliferation. FCM and RT-PCR were used to analyze the changes of nup98 mRNA and protein in K562 cells after treating with deguelin.
Qiu-Ling, Wu +3 more
openaire +2 more sources
Novel insights into immunopathogenesis and crucial biomarkers between primary open-angle glaucoma and systemic lupus erythematosus. [PDF]
IMetaOmicsThis study revealed a novel correlation between systemic lupus erythematosus (SLE) and primary open‐angle glaucoma (POAG) through comprehensive bioinformatics analysis and experimentation, identifying biomarkers and immunopathogenesis for future research and treatment of SLE‐related POAG.
Liu Y +5 more
europepmc +2 more sources
Amelioration of an undesired action of deguelin [PDF]
Toxicon, 2013 The pharmaceutical world has greatly benefited from the well-characterized structure-function relationships of toxins with endogenous biomolecules, such as ion-channels, receptors, and signaling molecules. Thus, therapeutics derived from toxins have been aggressively pursued.
Julie A, Vrana +3 more
openaire +2 more sources
Mitochondrial DNA mutations in ageing and cancer
Molecular Oncology, Volume 16, Issue 18, Page 3276-3294, September 2022., 2022 Mitochondrial DNA mutations are a common feature of ageing tissues and a number of human cancers. They can affect essential mitochondrial functions such as oxidative phosphorylation, redox balance, apoptosis, and numerous biosynthetic pathways. These are important mechanisms which reportedly impact tumour growth, though data are often contradictory ...
Anna L. M. Smith +2 more
wiley +1 more source