Results 41 to 50 of about 747 (158)

Development and Validation of Analytical Method for SH-1242 in the Rat and Mouse Plasma by Liquid Chromatography/Tandem Mass Spectrometry

Molecules, 2020
SH-1242, a novel inhibitor of heat shock protein 90 (HSP90), is a synthetic analog of deguelin: It was previously reported that the treatment of SH-1242 led to a strong suppression of hypoxia-mediated retinal neovascularization and vascular leakage in ...
Yoo-Seong Jeong, Minjeong Baek, Seungbeom Lee, Min-Soo Kim, Han-Joo Maeng, Jong-Hwa Lee, Young-Ger Suh, Suk-Jae Chung   +7 more
doaj   +1 more source

Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells [PDF]

Clinical & Experimental Metastasis, 2013
Cancer related deaths in breast cancer patients are due to metastasis of the disease. Murine 4T1 cells (Murine mammary cancer cell line developed from 6-thioguanine resistant tumor) provide an excellent research tool for metastasis related studies because these cells are highly aggressive and readily metastasize to the lungs.
Rajeshwari R, Mehta, Harshadadevi, Katta, Amit, Kalra, Rutulkumar, Patel, Akash, Gupta, Fatouma, Alimirah, Genoveva, Murillo, Xinjian, Peng, Aditya, Unni, Miguel, Muzzio, Rajendra G, Mehta   +10 more
openaire   +2 more sources

Sifat Antibakteri dari Daun Tephrosia vogelii Terhadap Vibriosis

Αl-Kimiya: Jurnal Ilmu Kimia dan Terapan, 2019
Sektor kelautan dan perikanan merupakan salah satu sumber andalan dalam produksi pembangunan perikanan di Indonesia. Udang merupakan salah satu komoditas unggulan utama dalam menunjang produksi pendapatan devisa non migas.
Eri Bachtiar, Yana Maolana Syah, Lia Dewi Juliawaty   +2 more
doaj   +1 more source

Potential Compounds for Oral Cancer Treatment: Resveratrol, Nimbolide, Lovastatin, Bortezomib, Vorinostat, Berberine, Pterostilbene, Deguelin, Andrographolide, and Colchicine. [PDF]

PLoS ONE, 2015
Oral cancer is one of the main causes of cancer-related deaths in South-Asian countries. There are very limited treatment options available for oral cancer.
Saurabh Bundela, Anjana Sharma, Prakash S Bisen   +2 more
doaj   +1 more source

GC-MS analysis of bioactive phytochemicals from methanolic leaf and root extracts of Tephrosia vogelii

Scientific African, 2022
The objective of this study was to determine the phytochemical compounds present in methanolic root and leaf extracts of Tephrosia vogelii. The plant species is found in the genus Tephrosia and family Fabaceae.
Stephano Hanolo Mlozi, Juma A. Mmongoyo, Musa Chacha   +2 more
doaj   +1 more source

Recent Advances in Carbonyl–Olefin and Carbonyl–Alkyne Metathesis Reactions

ChemistryEurope, Volume 4, Issue 4, April 2026.
Carbonyl–olefin and carbonyl–alkyne metathesis enable atom‐economic C–C bond formation beyond classical olefin metathesis. This review highlights recent advances in photochemical, Lewis‐acid, Brønsted‐acid, and organocatalytic strategies, mechanistic insights, and synthetic applications, showcasing carbonyl metathesis as a versatile platform for modern
Komal Kalonia, Ramees Komath, Martin Breugst   +2 more
wiley   +1 more source

Ethnomedicinal Practices of the Fabaceae Family in Tanzania: A Systematic Review

The Scientific World Journal, Volume 2026, Issue 1, 2026.
This study is aimed at reviewing the ethnomedicinal, phytochemical and pharmacological properties of Fabaceae species used as sources of traditional medications in Tanzania. Using the Systematic Reviews and Meta‐Analyses (PRISMA) methodology, a comprehensive review was conducted on Fabaceae species used by Tanzanians through electronic databases such ...
David Sylvester Kacholi, Kalyani Sen
wiley   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Inhibition of Autophagy by Deguelin Sensitizes Pancreatic Cancer Cells to Doxorubicin [PDF]

International Journal of Molecular Sciences, 2016
Pancreatic cancer is the fourth most common cause of cancer mortality worldwide. Furthermore, patients with pancreatic cancer experience limited benefit from current chemotherapeutic approaches because of drug resistance. Therefore, an effective therapeutic strategy for patients with pancreatic cancer is urgently required.
Xiao-Dong Xu, Yan Zhao, Min Zhang, Rui-Zhi He, Xiu-Hui Shi, Xing-Jun Guo, Cheng-Jian Shi, Feng Peng, Min Wang, Min Shen, Xin Wang, Xu Li, Ren-Yi Qin   +12 more
openaire   +2 more sources

Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway

Acta Pharmaceutica
Deguelin exhibits antiproliferative activity against various cancer cell types. Previous studies have reported that deguelin exhibits pro-apoptotic activity against human cancer cells. The current study aimed at further elaborating the anticancer effects
Sun Kening, Chen Ping, Zhang Liang, Lu Zhidong, Jin Qunhua   +4 more
doaj   +1 more source