Results 41 to 50 of about 1,019 (188)
Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain
, 2017 As a result of limited classes of anthelmintics and an over-reliance on chemical control, there is a great need to discover new compounds to combat drug resistance in parasitic nematodes. Here, we show that deguelin, a plant-derived rotenoid, selectively
Korhonen, Pasi K. +62 more
core +3 more sources
Larvicidal Activity of Isoflavonoids from Extracts Against
Natural Product Communications, 2012 The biological activity of extracts from the leaves, bark and roots of Muellera frutescens , an Amazonian ichtyotoxic plant, were evaluated to find new environmentally safe insecticides.
Charlotte Nirma +8 more
doaj +1 more source
The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts
Viruses, 2018 Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus for which there is no vaccine or cure. This viral infection, once acquired, is life-long, residing latently in hematopoietic cells.
Masatoshi Nukui +2 more
doaj +1 more source
Biomedicines, 2020 Signal transducer and activator of transcription 3 (STAT3) is a point of convergence for numerous oncogenic signals that are often constitutively activated in many cancerous or transformed cells and some stromal cells in the tumor microenvironment ...
Sung-Jun Hong +9 more
doaj +1 more source
Plants in the Genus Tephrosia: Valuable Resources for Botanical Insecticides
Insects, 2020 Synthetic insecticides are effective in controlling insect pests but can also harm nontarget organisms and the environment. During the last 40 years, there has been an increasing interest in alternative insecticides, particularly those derived from ...
Peiwen Zhang +3 more
doaj +1 more source
, 2017 Background. Deguelin has both antiproliferation and antimetastasis activities. However, high-dose deguelin elicits many undesired side effects. The purpose of this study was to investigate whether the low-dose deguelin can prevent the metastasis of oral ...
林思洸;郭彥彬 +1 more
core +1 more source
Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells
Cell Reports, 2018 Summary: A hallmark of advanced prostate cancer (PC) is the concomitant loss of PTEN and p53 function. To selectively eliminate such cells, we screened cytotoxic compounds on Pten−/−;Trp53−/− fibroblasts and their Pten-WT reference.
Adam Naguib +14 more
doaj +1 more source
Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer
Biomedicines, 2021 As a public health emergency of international concern, the highly contagious coronavirus disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of billions of individuals.
Liyan Yang, Zhonglei Wang
doaj +1 more source
A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and Therapy [PDF]
Cancer Prevention Research, 2008 Abstract The natural compound deguelin has promising preventive and therapeutic activity against diverse cancers by directly binding to heat shock protein-90 and thus suppressing its function. Potential side effects of deguelin over a certain dose, however, could be a substantial obstacle to its clinical use. To develop a derivative(s)
Woo-Young, Kim +14 more
openaire +2 more sources
Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells [PDF]
Clinical & Experimental Metastasis, 2013 Cancer related deaths in breast cancer patients are due to metastasis of the disease. Murine 4T1 cells (Murine mammary cancer cell line developed from 6-thioguanine resistant tumor) provide an excellent research tool for metastasis related studies because these cells are highly aggressive and readily metastasize to the lungs.
Rajeshwari R, Mehta +10 more
openaire +2 more sources