Results 61 to 70 of about 747 (158)

Heat shock protein 90: biological functions, diseases, and therapeutic targets

MedComm, Volume 5, Issue 2, February 2024.
Targeting the dynamic cycling of HSP90 and its interaction with co‐chaperones can promote protein maturation and client protein degradation, potentially offering effective antineoplastic strategies. Abstract Heat shock protein 90 (Hsp90) is a predominant member among Heat shock proteins (HSPs), playing a central role in cellular protection and ...
Huiyun Wei, Yingying Zhang, Yilin Jia, Xunan Chen, Tengda Niu, Aniruddha Chatterjee, Pengxing He, Guiqin Hou   +7 more
wiley   +1 more source

Deguelin inhibits human hepatocellular carcinoma by antiangiogenesis and apoptosis

Oncology Reports, 2008
Deguelin is a rotenoid isolated from several plant species, which has been reported to have chemopreventive effects in skin, mammary, colon and lung cancers. The effects of deguelin on the proliferation and apoptosis of hepatic cancer cells were assessed by MTT assay and flow cytometric analysis.
Ju-Hee, Lee, Don-Haeng, Lee, Hyun-Seung, Lee, Joon-Seok, Choi, Kyu-Won, Kim, Soon-Sun, Hong   +5 more
openaire   +3 more sources

Pharmacological basis and new insights of deguelin concerning its anticancer effects

Pharmacological Research, 2021
Deguelin is a rotenoid of the flavonoid family, which can be extracted from Lonchocarpus, Derris, or Tephrosia. It possesses the inhibition of cancer cell proliferation by inducing apoptosis through regulating the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway, the NF-κB signaling pathway, the Wnt signaling pathway, the ...
Zhu Yue, Lin, Qu Zhen, Yun, Liu, Wu, Tian Wen, Zhang, Tang Ze, Yao   +4 more
openaire   +2 more sources

A New Prenylated Flavanone from Derris trifoliata Lour.

Molecules, 2012
A new flavanone, 4′,5,7-trihydroxy-6,8-di-(2-hydroxy-3-methylbut-3-enyl)- flavanone, was isolated from the aerial parts of Derris trifoliate, together with eleven known compounds: rotenone, tephrosin, 12a-hydroxyrotenone, deguelin, 6a,12a-dehydro ...
Hao Yin, Si Zhang, Zhihui Xiao, Ximin Qiu, Cheng Jiang, Xiongming Luo, Weihong He, Shengzi Liu   +7 more
doaj   +1 more source

Antiproliferative Activities and SwissADME Predictions of Physicochemical Properties of Carbonyl Group‐Modified Rotenone Analogues

ChemistryOpen, Volume 13, Issue 1, January 2024.
Rotenone derivatives were synthesized through modifications of the carbonyl group and their antiproliferative activities were evaluated against various cancer cell lines (MCF‐7, A549, and HCT116). The physicochemical properties and drug‐likeness of the derivatives were evaluated using the SwissADME webtool.
Rajelle D. Hernandez, Frances Abygail F. Genio, Jannelle R. Casanova, Marlon T. Conato, Monissa C. Paderes   +4 more
wiley   +1 more source

Using LC and Hierarchical Cluster Analysis as Tools to Distinguish Timbó Collections into Two Deguelia Species: A Contribution to Chemotaxonomy

Molecules, 2016
The species Deguelia utilis and Deguelia rufescens var. urucu, popularly known as “timbó,” have been used for many years as rotenone sources in insecticide formulations.
Danielle da Costa, Consuelo e Silva, Aline Pinheiro, Débora Frommenwiler, Mara Arruda, Giselle Guilhon, Cláudio Alves, Alberto Arruda, Milton Da Silva   +8 more
doaj   +1 more source

Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway

Cancer Management and Research, 2018
Liubo Chen,1,2,* Kai Jiang,1,2,* Haiyan Chen,1,3,* Yang Tang,1,2 Xinyi Zhou,1,2 Yinuo Tan,1,4 Ying Yuan,1,4 Qian Xiao,1,2 Kefeng Ding1,2 1Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key ...
Chen L, Jiang K, Chen H, Tang Y, Zhou X, Tan Y, Yuan Y, Xiao Q, Ding K   +8 more
doaj  

Resveratrol Inhibits the Epidermal Growth Factor-Induced Migration of Osteoblasts: the Suppression of SAPK/JNK and Akt

Cellular Physiology and Biochemistry, 2017
Background/Aims: Resveratrol is a polyphenol enriched in the skins of grapes and berries, that shows various beneficial effects for human health. In the present study, we investigated the mechanism behind the epidermal growth factor (EGF)-induced ...
Tetsu Kawabata, Haruhiko Tokuda, Kazuhiko Fujita, Shingo Kainuma, Go Sakai, Rie Matsushima-Nishiwaki, Osamu Kozawa, Takanobu Otsuka   +7 more
doaj   +1 more source

Deguelin and Paclitaxel Loaded PEG-PCL Nano-Micelles for Suppressing the Proliferation and Inducing Apoptosis of Breast Cancer Cells

Frontiers in Bioscience-Landmark
Background: Deguelin (DGL) is a natural flavonoid reported to exhibit antitumor effects in breast cancer (BC). PEG-PCL (Polyethylene Glycol- Polycaprolactone), as polymeric micelles, has biodegradability and biocompatibility. The aim of this study was to
Yali Wang, Yang Lan, Liang Wu, Shijin Zhang, Qiang Su, Qin Yang   +5 more
doaj   +1 more source

Kajian Heat Shock Protein 90 (HSP90) dalam Pencarian Kandidat Penghambatnya melalui Ekplorasi Bahan Alam Indonesia

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 2019
Exploration on anticancer candidates on inhibition of Heat Shock Protein (HSP) activity are increasing in the past ten years. Some of HSP90 inhibitor candidates were in third phase of clinical trials.
Rehmadanta Sitepu
doaj   +1 more source