Results 61 to 70 of about 1,019 (188)
Cancer Cell International, 2021 Background Morphine, a µ-opioid receptor (MOR) agonist, has been shown to be related to the activity of cancer cells, and a higher morphine dosage reduces the survival time of patients with lung cancer.
Xingyun Liu +6 more
doaj +1 more source
Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer
Oncology Reports, 2010 Gastric cancer is often diagnosed in locally advanced or metastatic stages, which preludes a poor prognosis. As only 10% of patients with advanced gastric cancer treated with chemotherapy survive 2 years, new approaches for preventing and controlling the disease are required. We therefore, assessed in gastric cancer cells the chemotherapeutic potential
Hyunseung, Lee +3 more
openaire +3 more sources
Health Science Reports, Volume 7, Issue 12, December 2024.ABSTRACT Background and Aims The biological function of lysosomes has been increasingly appreciated in cancer. However, the relationship between lysosome and lung adenocarcinoma (LUAD) was not well understood. In this study, a lysosome‐related signature was developed for LUAD risk stratification and prognosis prediction.
Wei Ye +4 more
wiley +1 more source
Deguelin down-regulates survivin and Cdk4.
, 2013 Hep-2 cells were exposed to deguelin at indicated concentration (10, 25, 50 and 100 µM) for 24 hours, expression levels of survivin, Cdk4 and tubulin were measured by western blot (A).The association between survivin, Cdk4 and Hsp 90 as well as the ...
Chun-cheng Lu (276392) +6 more
core +1 more source
Deguelin inhibits human hepatocellular carcinoma by antiangiogenesis and apoptosis
Oncology Reports, 2008 Deguelin is a rotenoid isolated from several plant species, which has been reported to have chemopreventive effects in skin, mammary, colon and lung cancers. The effects of deguelin on the proliferation and apoptosis of hepatic cancer cells were assessed by MTT assay and flow cytometric analysis.
Ju-Hee, Lee +5 more
openaire +3 more sources
Potentiation of fludarabine action by deguelin.
, 2016 PBMCs from 2 CLL patients were treated with 10 μM deguelin, 1 μg/ml fludarabine or the combination of both, and co-cultured with 3T3-CD40L cell line up to 120h (same samples as in Fig 4B, 4C and 4D).
Silvia Rosado (39145) +9 more
core +1 more source
Food Science &Nutrition, Volume 12, Issue 5, Page 3025-3045, May 2024.Polyphenols, such as kaempferol, catechins, apigenin, chlorogenic acid, rosmarinic acid, and caffeic acid, have shown their ability to serve as potential antidiabetic medicines. Also, the use of polyphenols might have a few side effects although relatively less than available medications. Abstract In the middle of an ever‐changing landscape of diabetes
Dipa Aryal +11 more
wiley +1 more source
Brown Stink Bug Mortality by Seed Extracts of Tephrosia Vogelii Containing Deguelin and Tephrosin
Brazilian Archives of Biology and Technology, 2018 Extracts of the seeds of Tephrosia vogelii Hook. f. were studied in relation to its chemical composition and toxicity to the brown stink bug Euschistus heros (F.).
Adriana Yatie Mikami +2 more
doaj +1 more source
Chemistry &Biodiversity, Volume 21, Issue 4, April 2024.Abstract This perspective delves into the investigation of synthetic and naturally occurring inhibitors, their patterns of inhibition, and the effectiveness of newly utilized natural compounds as inhibitors targeting the Ornithine decarboxylase enzyme. This enzyme is known to target the MYC oncogene, thereby establishing a connection between polyamine ...
Preeti Nanda Sahu, Anik Sen
wiley +1 more source
Pharmacological basis and new insights of deguelin concerning its anticancer effects
Pharmacological Research, 2021 Deguelin is a rotenoid of the flavonoid family, which can be extracted from Lonchocarpus, Derris, or Tephrosia. It possesses the inhibition of cancer cell proliferation by inducing apoptosis through regulating the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway, the NF-κB signaling pathway, the Wnt signaling pathway, the ...
Zhu Yue, Lin +4 more
openaire +2 more sources