Results 71 to 80 of about 1,019 (188)

Heat shock protein 90: biological functions, diseases, and therapeutic targets

MedComm, Volume 5, Issue 2, February 2024.
Targeting the dynamic cycling of HSP90 and its interaction with co‐chaperones can promote protein maturation and client protein degradation, potentially offering effective antineoplastic strategies. Abstract Heat shock protein 90 (Hsp90) is a predominant member among Heat shock proteins (HSPs), playing a central role in cellular protection and ...
Huiyun Wei, Yingying Zhang, Yilin Jia, Xunan Chen, Tengda Niu, Aniruddha Chatterjee, Pengxing He, Guiqin Hou   +7 more
wiley   +1 more source

Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever

Química Nova, 2012
In the search for new larvicides from plants, we have investigated the potential activity of the rotenoids deguelin (1), 12a-hydroxy-α-toxicarol (2) and tephrosin (3), isolated from the bioactive ethanol extract of roots of Tephrosia toxicaria Pers ...
Jackson Nunes e Vasconcelos, Gilvandete Maria Pinheiro Santiago, Jefferson Queiroz Lima, Jair Mafezoli, Telma Leda Gomes de Lemos, Francisca Renata Lopes da Silva, Mary Anne Sousa Lima, Antônia Torres Ávila Pimenta, Raimundo Braz-Filho, Angela Martha Campos Arriaga, Dari Cesarin-Sobrinho   +10 more
doaj   +1 more source

Antiproliferative Activities and SwissADME Predictions of Physicochemical Properties of Carbonyl Group‐Modified Rotenone Analogues

ChemistryOpen, Volume 13, Issue 1, January 2024.
Rotenone derivatives were synthesized through modifications of the carbonyl group and their antiproliferative activities were evaluated against various cancer cell lines (MCF‐7, A549, and HCT116). The physicochemical properties and drug‐likeness of the derivatives were evaluated using the SwissADME webtool.
Rajelle D. Hernandez, Frances Abygail F. Genio, Jannelle R. Casanova, Marlon T. Conato, Monissa C. Paderes   +4 more
wiley   +1 more source

A New Prenylated Flavanone from Derris trifoliata Lour.

Molecules, 2012
A new flavanone, 4′,5,7-trihydroxy-6,8-di-(2-hydroxy-3-methylbut-3-enyl)- flavanone, was isolated from the aerial parts of Derris trifoliate, together with eleven known compounds: rotenone, tephrosin, 12a-hydroxyrotenone, deguelin, 6a,12a-dehydro ...
Hao Yin, Si Zhang, Zhihui Xiao, Ximin Qiu, Cheng Jiang, Xiongming Luo, Weihong He, Shengzi Liu   +7 more
doaj   +1 more source

Using LC and Hierarchical Cluster Analysis as Tools to Distinguish Timbó Collections into Two Deguelia Species: A Contribution to Chemotaxonomy

Molecules, 2016
The species Deguelia utilis and Deguelia rufescens var. urucu, popularly known as “timbó,” have been used for many years as rotenone sources in insecticide formulations.
Danielle da Costa, Consuelo e Silva, Aline Pinheiro, Débora Frommenwiler, Mara Arruda, Giselle Guilhon, Cláudio Alves, Alberto Arruda, Milton Da Silva   +8 more
doaj   +1 more source

Thin Layer Densitometric Determination of Rotenone and Deguelin

Journal of AOAC INTERNATIONAL, 1969
Abstract Rutenone and deguelin are separated by chromatography on silver nitrate-impregnated silica gel G with chloroform acetone: acetic acid (196:3:1) solvent system. Glass plates, 20 × 20 cm, are coated with a special spreader producing a 0.25 mm layer and a 1.00 mm band at the upper end.
William H Tallent, Norman E Delfel
openaire   +1 more source

Deguelin activates AMPK signaling.

, 2013
Hep-2 cells were exposed to 100 µM of deguelin for indicated time points, followed by western blot detecting phospho- and total- level of LKB1-AMPK-ACC using specific antibodies (A).
Chun-cheng Lu (276392), Chao Ji (276390), Zhi-gang Bi (276391), Bing Gu (276393), Lei Cheng (171055), Rong Wang (59795), Yan-li Yang (276389)   +6 more
core   +1 more source

Deguelin induces cellular ceramide synthesis.

, 2013
Hep-2 cells were exposed to 100 µM of deguelin with or without fumonisin B1 (20 µM) for indicated time points, intracellular ceramide level was analyzed using methods mentioned above (A). Hep-2 cells were treated with fumonisin B1 (20 µM) or C6-ceramide (
Chun-cheng Lu (276392), Chao Ji (276390), Zhi-gang Bi (276391), Bing Gu (276393), Lei Cheng (171055), Rong Wang (59795), Yan-li Yang (276389)   +6 more
core   +1 more source

Resveratrol Inhibits the Epidermal Growth Factor-Induced Migration of Osteoblasts: the Suppression of SAPK/JNK and Akt

Cellular Physiology and Biochemistry, 2017
Background/Aims: Resveratrol is a polyphenol enriched in the skins of grapes and berries, that shows various beneficial effects for human health. In the present study, we investigated the mechanism behind the epidermal growth factor (EGF)-induced ...
Tetsu Kawabata, Haruhiko Tokuda, Kazuhiko Fujita, Shingo Kainuma, Go Sakai, Rie Matsushima-Nishiwaki, Osamu Kozawa, Takanobu Otsuka   +7 more
doaj   +1 more source

Concise Total Synthesis of (±)-Deguelin and (±)-Tephrosin Using a Vinyl Iodide as a Key Building Block

, 2018
A concise and protecting-group-free total synthesis of the antiproliferative natural product (±)-deguelin (2) was accomplished in four steps and 62% overall yield from commercially available precursors.
Shengtao Xu (513564), Guangyu Wang (553563), Aijun Lin (1393531), Jinyi Xu (1748593), Wenlong Li (571749), Hequan Yao (1393537), Feijie Xu (4852714)   +6 more
core   +1 more source