Results 91 to 100 of about 1,019 (188)
Pharmacological inhibition of PI3K/AKT activity by deguelin to treat oral cancers
, 2007 魚藤素(deguelin)是一種非常具有發展潛力，可以抵抗癌症細胞生長的天然合成藥物。其主要機制在於抑制細胞AKT 蛋白的活性，在許多癌細胞種類中已經被證明AKT 蛋白都有過度活化的情況，如支氣管上皮細胞癌、結腸癌、急性骨髓白血病(acute myeloid leukemia，AML)、非小細胞肺癌(NSCLC)、乳癌以及皮膚鱗狀細胞(cutaneous squamous cell)，在使用魚藤素治療後具有很好的抑 癌功效。但是在口腔癌治療研究中則未被證實有任何功能以及在口腔癌中p ...
江耿男, Chiang, Geng-Nan
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, 2018 Deguelin, a rotenoid, is isolated from a natural plant species, and has biological activities including antitumor function. In the present study, we investigated the effect of deguelin on the cell adhesion, migration and invasion of NCI-H292 human lung ...
Jaw-Chyun Chen +8 more
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AMPK-dependent autophagy pathway contributes to deguelin-induced Hep-2 cell death.
, 2013 Hep-2 cells were pretreated with Z-VAD-fmk (50 µM) or 3-MA (2 mM) for 1 hr before deguelin exposure for 72 hours, cell viability was measured by MTT assay (A).
Chun-cheng Lu (276392) +6 more
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, 2012 [[abstract]]It has been shown that deguelin, one of the compounds of rotenoids from flavonoid family, induced cytotoxic effects through induction of cell cycle arrest and apoptosis in many types of human cancer cell lines, but deguelin-affected DNA ...
鍾景光;Chung, Jing-Gung
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Deguelin induces cytotoxicity dependent on dose in primary CLL cells.
, 2016 PBMCs from CLL patients (n = 35) and healthy donors (n = 10) were incubated with or without deguelin for 48 h. Apoptosis was evaluated by flow cytometry after double staining with Annexin V-FITC and PI and it is expressed as a percentage relative to a ...
Silvia Rosado (39145) +9 more
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, 2013 Deguelin affects EGFR/c-Met and their downstream target molecules such as p-STAT3, p-ERK, p-AKT, c-Myc and Survivin and there by affect growth/survival of breast cancer cells.
Harshadadevi Katta (419863) +7 more
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, 2016 Deguelin exhibits potent apoptotic and antiangiogenic activities in a variety of transformed cells and cancer cells. Deguelin also exhibits potent tumor suppressive effects in xenograft tumor models for many human cancers.
Ji-Hyeon Park (554738) +21 more
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, 2009 Objective: To investigate the effects of deguelin on the proliferation inhibition and apoptosis induction in RPMI-8226 cells in vitro, as well as the regulation of steroid receptor coactivator-3 (SRC-3) to explore the relationship between them.
Shu, W-X, Chen, Y, Li, R
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Total Synthesis of dl-Deguelin
Agricultural and Biological Chemistry, 1960 FUKAMI, Hiroshi +3 more
openaire +3 more sources
DEGUELIN AS A THERAPEUTIC DRUG FOR TRIPLE NEGATIVE AND METASTATIC BREAST CANCER
, 2011 Breast cancer is a second leading cause of cancer related deaths. 15-20 % of women with Breast cancer are diagnosed with Triple negative breast cancer (ER, PR, and HER2 –ve) which is the most aggressive type showing higher incidence of recurrence at the ...
Kalra, Amit
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