Results 81 to 90 of about 1,094 (192)
Frontiers in Bioscience-LandmarkBackground: Deguelin (DGL) is a natural flavonoid reported to exhibit antitumor effects in breast cancer (BC). PEG-PCL (Polyethylene Glycol- Polycaprolactone), as polymeric micelles, has biodegradability and biocompatibility. The aim of this study was to
Yali Wang +5 more
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Effect of Deguelin on the growth and expression of signaling molecules in TNBC cells.
, 2013 A. Effect of deguelin on MDA-MB 231 cells in the presence of EGF (1 ng or 20 ng) alone, Deguelin alone (31–500 nM)or Deguelin+EGF. The cells were plated in six well plates, allowed to attach overnight, then treated with indicated test compound/(s) (in ...
Harshadadevi Katta (419863) +7 more
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Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 2019 Exploration on anticancer candidates on inhibition of Heat Shock Protein (HSP) activity are increasing in the past ten years. Some of HSP90 inhibitor candidates were in third phase of clinical trials.
Rehmadanta Sitepu
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Cytotoxic effects of deguelin in cultured HNSCC cells.
, 2013 Hep-2 cells were exposed to deguelin at a various concentration (10, 25, 50, 100 and 200 µM) for 72 hours (A) or exposed to 100 µM of deguelin for different time points (12, 24, 48 and 72 hours) (B), cell viability was then measured by MTT assay.
Chun-cheng Lu (276392) +6 more
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PLoS ONE, 2015 Plants with pesticidal properties have been investigated for decades as alternatives to synthetics, but most progress has been shown in the laboratory. Consequently, research on pesticidal plants is failing to address gaps in our knowledge that constrain
Prisila Mkenda +5 more
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Viruses, 2019 Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that establishes a lifelong persistence in the host through both chronic and latent states of infection [...]
Beatrice Mercorelli +4 more
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STUDIES TOWARD TOTAL SYNTHESIS OF (-)-DEGUELIN
, 2013 Deguelin, as a rotenoid, has emerged as an attractive pharmacophore for chemprevention due to its effectiveness for both in vitro and in vivo models.
Li, Bao
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Deguelin downregulates AKT/NFκB mediated prosurvival signals in CLL cells.
, 2016 (A) PBMCs from 3 CLL patients were treated for 24h with 0, 10, or 100 μM deguelin. Viability was evaluated by flow cytometry after Annexin V/IP staining. Figure shows immunoreactive bands for several deguelin target molecules and β-actin in western blots
Silvia Rosado (39145) +9 more
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Deguelin gavage is well tolerated.
, 2013 Bodyweight is determined before and after Deguelin treatment. The gain in bodyweight is a sign for good tolerance of the substance. The graph represents the increases in bodyweight vs. weight at begin of the experiment.
Bertram Scheller (318724) +8 more
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, 2018 Deguelin, a rotenoid, is isolated from a natural plant species, and has biological activities including antitumor function. In the present study, we investigated the effect of deguelin on the cell adhesion, migration and invasion of NCI-H292 human lung ...
Jaw-Chyun Chen +8 more
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