Results 31 to 40 of about 747 (158)
Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022 Non‐small‐cell lung cancer (NSCLC) is known as one of the most lethal cancers, causing more than 1 million deaths annually worldwide. Therefore, the development of novel therapeutic drugs for NSCLC has become an urgent need. Herein, various mouse models provide great convenience not only for researchers but also for the development of antitumor drug ...
Hongkui Chen +6 more
wiley +1 more source
Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat. [PDF]
PLoS ONE, 2012 The main goal of adequate organ preservation is to avoid further cellular metabolism during the phase of ischemia. However, modern preservation solutions do rarely achieve this target.
Patrick Paulus +8 more
doaj +1 more source
Larvicidal Activity of Isoflavonoids from Extracts Against
Natural Product Communications, 2012 The biological activity of extracts from the leaves, bark and roots of Muellera frutescens , an Amazonian ichtyotoxic plant, were evaluated to find new environmentally safe insecticides.
Charlotte Nirma +8 more
doaj +1 more source
Stereocontrolled semi-syntheses of deguelin and tephrosin
Organic & Biomolecular Chemistry, 2017 We describe stereocontrolled semi-syntheses of deguelin and tephrosin, anti-cancer rotenoids isolated from Tephrosia vogelii .
Russell, David A +4 more
openaire +4 more sources
Biomedicines, 2020 Signal transducer and activator of transcription 3 (STAT3) is a point of convergence for numerous oncogenic signals that are often constitutively activated in many cancerous or transformed cells and some stromal cells in the tumor microenvironment ...
Sung-Jun Hong +9 more
doaj +1 more source
Plants in the Genus Tephrosia: Valuable Resources for Botanical Insecticides
Insects, 2020 Synthetic insecticides are effective in controlling insect pests but can also harm nontarget organisms and the environment. During the last 40 years, there has been an increasing interest in alternative insecticides, particularly those derived from ...
Peiwen Zhang +3 more
doaj +1 more source
Deguelin action involves c-Met and EGFR signaling pathways in triple negative breast cancer cells.
PLoS ONE, 2013 BackgroundTreatment of breast cancer patients with antiestrogens and aromatase inhibitor(s) or Herceptin have shown significant success in steroid receptor positive or Her-2+ breast cancers respectively.
Rajeshwari Mehta +7 more
doaj +1 more source
Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells
Cell Reports, 2018 Summary: A hallmark of advanced prostate cancer (PC) is the concomitant loss of PTEN and p53 function. To selectively eliminate such cells, we screened cytotoxic compounds on Pten−/−;Trp53−/− fibroblasts and their Pten-WT reference.
Adam Naguib +14 more
doaj +1 more source
Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer
Biomedicines, 2021 As a public health emergency of international concern, the highly contagious coronavirus disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of billions of individuals.
Liyan Yang, Zhonglei Wang
doaj +1 more source
A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and Therapy [PDF]
Cancer Prevention Research, 2008 Abstract The natural compound deguelin has promising preventive and therapeutic activity against diverse cancers by directly binding to heat shock protein-90 and thus suppressing its function. Potential side effects of deguelin over a certain dose, however, could be a substantial obstacle to its clinical use. To develop a derivative(s)
Woo-Young, Kim +14 more
openaire +2 more sources