Results 221 to 230 of about 64,618 (285)

Rotenone accelerates endogenous α-synuclein spreading and enhances neurodegeneration in an intra-striatal α-synuclein preformed fibril injected mouse model of Parkinson's disease. [PDF]

Front Cell Neurosci
Khan E, Radwan N, Ardah MT, Kitada T, Haque ME.   +4 more
europepmc   +1 more source

Re‐conceptualizing Parkinson's disease as a lifelong neurobiological trajectory: A framework for prevention

Neuroprotection, Volume 4, Issue 1, Page 14-29, March 2026.
Three‐panel graphical abstract showing the Lifelong Neurobiological Trajectory framework for Parkinson's disease: (1) Vulnerability pathway (top, red) showing how early adversity → epigenetic dysregulation, neuroinflammation, and mitochondrial dysfunction → ↑ PD risk; (2) Lifespan timeline (middle, purple) spanning prenatal/infancy → childhood ...
Ayodeji Johnson Ajibare, Abraham Olufemi Asuku, Olabode Oluwadare Akintoye   +2 more
wiley   +1 more source

p75NTR Modulation by LM11A-31 Counteracts Oxidative Stress and Cholesterol Dysmetabolism in a Rotenone-Induced Cell Model of Parkinson's Disease. [PDF]

Neurochem Res
Pensabene D, Martella N, Scavo G, Bisesto E, Cavicchia F, Colardo M, Varone M, Moreno S, Segatto M.   +8 more
europepmc   +1 more source

Host Aging Induces a Senescent‐Like Phenotype in Neutrophils and Altered Transcriptional Responses to Streptococcus pneumoniae

Aging Cell, Volume 25, Issue 3, March 2026.
Aging is associated with a senescent‐like phenotype in neutrophils that emerges in bone marrow cells; however, many facets of this phenotype are only fully acquired upon entry into peripheral tissues. This neutrophil senescent‐like phenotype is in part driven by TNFα and impairs resistance of aged hosts to S. pneumoniae. Created in BioRender. Boughanem
Michael C. Battaglia, Manmeet Bhalla, Brandon Marzullo, Anagha Betadpur, Alexsandra P. Lenhard, Rania Hassan Mohamed, Murat C. Kalem, Lauren R. Heinzinger, Pathricia A. Leus, Samuel Labarron, Lee Ann Garrett‐Sinha, Joan Mecsas, Anna Blumental‐Perry, Elsa N. Bou Ghanem   +13 more
wiley   +1 more source

Sport improves function of roosters testicular Leydig cells by mediating FUNDC1. [PDF]

Poult Sci
Chen Y, Zhao X, Zheng J, Zhang Y, Chen H, Cui C, Yu C, Yang C, Yin H, Han S.   +9 more
europepmc   +1 more source

Glycative Stress Disrupts the Mitochondrial‐Lysosome Axis and Promotes Geroconversion in Aging Cardiomyocytes

Aging Cell, Volume 25, Issue 3, March 2026.
Cardiac aging promotes mitochondrial AGE accumulation driven by defective glycative stress detoxification. AGE‐modified mitochondria disrupt lysosomal proteolysis, impairing mitophagy and promoting lipofuscin buildup. This mechanism sustains chronic unresolved mitochondrial damage, driving proinflammatory senescence in cardiomyocytes and defining a ...
Diana Bou‐Teen, Simonas Valiuska, Elisabet Miro‐Casas, Chiara Rubeo, Elena Bonzon‐Kulichenko, Zuzana Nichtova, Celia Fernandez‐Sanz, Javier Inserte, Antonio Rodriguez‐Sinovas, Begoña Benito, Eduard Ródenas‐Alesina, Jesús Vázquez, Ignacio Ferreira‐González, Marisol Ruiz‐Meana   +13 more
wiley   +1 more source

ZC3H4, a novel regulator of mitochondrial complex I, impacts prostate stromal cell senescence, attachment, adhesion and anoikis resistance. [PDF]

Cell Death Dis
Liu TT, Carrarini MJ, Myklebust LK, Skalitzky KO, El-Khoury N, Sipula IJ, Chang A, Soman V, Liu A, Ihejirika N, Chandran UR, Jurczak MJ, Ricke WA, DeFranco DB, Pascal LE.   +14 more
europepmc   +1 more source

PIK‐III‐Mediated Elevation of Thiamine Re‐Sensitises Renal Cell Carcinoma to Cuproptosis via Activating PDHA1

Cell Proliferation, Volume 59, Issue 3, March 2026.
PIK‐III enhancing the efficacy of cuproptosis to kill renal cancer cells through dysregulating thiamine metabolism and dephosphorylation of pyruvate dehydrogenase complex E1 (PDHA1), providing a potential option for treatment of cuproptosis‐resistant renal cancer by the combination of PIK‐III and elesclomol.
Dongdong Xie, Yu Wang, Wenjie Cheng, Minbo Yan, Kunyu Li, Xiang Wu, Jiaqing Wu, Zhuangzhuang Zhang, Yingbo Dai   +8 more
wiley   +1 more source

Antistunting potential of deepsea water concentrate as multivitamin granules: stability and in vivo activity study. [PDF]

Sci Rep
Hartesi B, Retnoaji B, Sriwidodo S, Wardhana YW, Muhaimin M, Dewi MK, Muttaqien SE, Chaerunisaa AY.   +7 more
europepmc   +1 more source

Nanoengineered photosensitizers for photodynamic priming to overcome P‐glycoprotein‐mediated multidrug resistance

Photochemistry and Photobiology, Volume 102, Issue 2, Page 328-350, March/April 2026.
Verteporfin's subcellular localization governs its ability to deplete ATP. LysoPC‐conjugated VP accumulates in lysosomes and spares mitochondria, while liposomal and NanoVP formulations target mitochondria, where light activation triggers membrane depolarization and ATP depletion, overcoming resistance seen with free‐form VP. Abstract P‐glycoprotein (P‐
Idrisa Rahman, Anju Meda, Kaitlyn A. Moore, Payal Srivastava, Anika Dasgupta, Andaleeb Sajid, Suresh V. Ambudkar, Huang‐Chiao Huang   +7 more
wiley   +1 more source