Results 231 to 240 of about 65,398 (283)

Innovative approach in Parkinson's targeting via berberine-loaded mucoadhesive surface-modified liposomes: a multi-faceted study. [PDF]

BMC Pharmacol Toxicol
Nematalla HA, Elharoun M, Abd-Alhaseeb MM, Sharafeldin HA, Elsheikh MA, Abbas H, Elkelish A, Dossouvi KM, Mehana AE, Abdelgawad FE, Zewail M.   +10 more
europepmc   +1 more source

Blood Cell Mitochondrial Respiration Increases With Age and Varies by Sex in Healthy Adults

Aging Cell, Volume 25, Issue 2, February 2026.
Using samples from the San Diego Nathan Shock Center Clinical Cohort, we found that blood cell bioenergetic capacity is generally positively associated with age and sex dependent. These findings highlight the importance of biological context in bioenergetics research. Created in BioRender. Lab, M. (2025) https://BioRender.com/pvgt48f.
Howard J. Phang, Jaclyn Bergstrom, Benjamin Keri, Stephanie R. Heimler, Stephen Dozier, Lina M. Scandalis, David Wing, Daniel Moreno, Nina N. Sun, Anthony J. A. Molina   +9 more
wiley   +1 more source

Reorganization of Mitochondrial Function and Architecture in Response to Plant-Derived Alkaloids: Anatabine, Anabasine, and Nicotine, Investigated in SH-SY5Y Cells and in a Cellular Model of Parkinson's Disease. [PDF]

CNS Neurosci Ther
Malińska D, Drabik K, Michalska B, Walczak J, Partyka M, Prill M, Szymański J, Patalas-Krawczyk P, Piecyk K, Duszyński J, Więckowski MR, Szczepanowska J.   +11 more
europepmc   +1 more source

Disruption of ATP Synthase Spatiotemporal Organization, Ca2+ Dynamics, and Contractile Function in Senescent Cardiomyocytes

Aging Cell, Volume 25, Issue 2, February 2026.
Enhanced ATP hydrolysis, ΔΨm flickering, and destabilized ATP synthase dimers collectively reduce ATP availability in senescent cardiomyocytes. This energy deficit is associated with disrupted Ca2⁺ dynamics and contractility. ABSTRACT Heart disease is the leading cause of death in the elderly population.
Silke Morris, Nico Marx, Gonzalo Barrientos, Isidora Molina‐Riquelme, Frank Schmelter, Hugo E. Verdejo, Stefan Peischard, Guiscard Seebohm, Verónica Eisner, Karin B. Busch   +9 more
wiley   +1 more source

Oenological tannins mitigate rotenone-induced mitochondrial impairments and oxidative stress, with concomitant detection of urolithin A in the brain. [PDF]

Biochem Biophys Rep
Wojciechowska O, Jourdes M, Andrusiewicz M, Pokrzywa M, Karaźniewicz-Łada M, Jodynis-Liebert J, Teissedre PL, Kujawska M.   +7 more
europepmc   +1 more source

Overactivation of Cdc42 GTPase Impairs the Cytotoxic Function of NK Cells From Old Individuals Towards Senescent Fibroblasts

Aging Cell, Volume 25, Issue 2, February 2026.
Unrestrained Cdc42 activity causes failure of cytotoxic function of old NK cells. This is associated with disruption of microtubular network and impaired mitochondrial ATP resulting in reduced conjugation and impaired degranulation of lytic vesicles.
Albert Kallon Koroma, Karmveer Singh, Yongfang Wang, Linda Krug, Philipp Haas, Meinhard Wlaschek, Vadim Sakk, Tanja Schuster, Daniel Fürst, Hubert Schrezenmeier, Rashmi Priyadharshini Dheenadayalan, Stephan Stilgenbauer, Lutz Walter, Hartmut Geiger, Karin Scharffetter‐Kochanek, Pallab Maity   +15 more
wiley   +1 more source

N-Acetyldopamine Dimer from Cicadidae Periostracum Is Enantioselectively Neuroprotective via Antioxidant Property. [PDF]

Biomol Ther (Seoul)
Thapa P, Khanal S, Gulam K, Ngo TH, Chen Z, Ok YJ, Lee KJ, Choi H, Nam JW, Choi DY.   +9 more
europepmc   +1 more source

Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson's model. [PDF]

NPJ Parkinsons Dis
Tsalenchuk M, Farmer K, Castro S, Scheirer A, Ye Y, Timothy Greenamyre J, Rocha EM, Marzi SJ.   +7 more
europepmc   +1 more source

Exposure to Mitochondrial Toxins: An In Vitro Study of Energy Depletion and Oxidative Stress in Driving Dopaminergic Neuronal Death in MN9D Cells. [PDF]

Toxics
Adetuyi OA, Wimalasena K.
europepmc   +1 more source