Results 41 to 50 of about 10,010,302 (244)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

A scalable and effective rough set theory-based approach for big data pre-processing

, 2020
International audienceA big challenge in the knowledge discovery process is to perform data pre-processing, specifically feature selection, on a large amount of data and high dimensional attribute set.
Lebbah, Mustapha, Chelly Dagdia, Zaineb, Christine Zarges, Beck, Gaël, Gaël Beck, Zaineb Chelly Dagdia, Mustapha Lebbah, Zarges, Christine   +7 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Decision-Making Approach Based on Neutrosophic Rough Information

Algorithms, 2018
Rough set theory and neutrosophic set theory are mathematical models to deal with incomplete and vague information. These two theories can be combined into a framework for modeling and processing incomplete information in information systems.
Muhammad Akram, Nabeela Ishfaq, Sidra Sayed, Florentin Smarandache   +3 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Multigranulations Rough Set Method of Attribute Reduction in Information Systems Based on Evidence Theory

Journal of Applied Mathematics, 2014
Attribute reduction is one of the most important problems in rough set theory. However, from the granular computing point of view, the classical rough set theory is based on a single granulation.
Minlun Yan
doaj   +1 more source

Partial approximative set theory: A generalization of the rough set theory [PDF]

2010 International Conference of Soft Computing and Pattern Recognition, 2010
There are close links between mathematical morphology and rough set theory. Both theories are successfully applied among others to image processing and pattern recognition. This paper presents a new generalization of the classical rough set theory, called the partial approximative set theory (PAST).
openaire   +1 more source