Results 271 to 280 of about 220,739 (296)
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The round window as access route for agents injurious to the inner ear
American Journal of Otolaryngology, 1988The ototoxicity of 50% propylene glycol, 70% isopropyl alcohol, 2% acetic acid, Otic Domeboro solution (Miles Pharmaceuticals, West Haven, CT), 1% Gentian violet (Purepac Pharmaceutical, Elizabeth, NJ), Vosol Otic solution (Wallace Laboratories, Cranbury, NJ), Genoptic Ophthalmic solution (Allergan Pharmaceuticals, Irvine, CA), Cortisporin Otic ...
O, Spandow, M, Anniko, A R, Møller
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An Experimental Study of Inner Ear Pathology due to NaCl on the Round Window
Acta Oto-Laryngologica, 1986An animal experiment was performed to evaluate structural and ultrastructural changes to the inner ear as a result of placing 3-4 crystals of reagent grade sodium chloride (NaCl) on the round window membrane. Chinchillas were sacrificed at 8 and 24 hours after treatment and the cochlear and vestibular tissues were examined by light microscopy and ...
COLLETTI, Vittorio +2 more
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Round window gentamicin application: an inner ear hair cell damage protocol for the mouse
Hearing Research, 2004It is important to develop an inner ear damage protocol for mice that avoids systemic toxicity and produces damage in a relatively rapid fashion, allowing for study of early cellular and molecular mechanisms responsible for hair cell death and those that underlie the lack of hair cell regeneration in mammals.
Jennifer L, Heydt +3 more
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Effects of Round Window Membrane Rupture on Cochlear Blood Flow and Inner Ear Pressures
Acta Oto-Laryngologica, 1988Effects of round window membrane rupture on cochlear blood flow and inner ear pressures were investigated using non-radioactive microspheres and a servo-micropipet system in guinea pigs. When perilymphatic pressure was raised through a glass capillary tube inserted into the perilymphatic space, both endolymph pressure and perilymph pressure rose.
T, Nakashima +3 more
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ORL, 1989
A suspension of 2% hydrocortisone, micronized in sterile water, was instilled through a perforation in the tympanic membrane into the round window (RW) niche of 9 healthy rats once a day for 5 consecutive days. Three animals were used as controls, and were exposed to sterile water only instilled into the RW niche.
O, Spandow, M, Anniko, S, Hellström
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A suspension of 2% hydrocortisone, micronized in sterile water, was instilled through a perforation in the tympanic membrane into the round window (RW) niche of 9 healthy rats once a day for 5 consecutive days. Three animals were used as controls, and were exposed to sterile water only instilled into the RW niche.
O, Spandow, M, Anniko, S, Hellström
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Toxic Effects on Inner Ear of Noxious Agents Passing Through the Round Window Membrane
Acta Oto-Laryngologica, 1988The effects on inner ear of Xylocain, EMLA, phenol, endotoxin and hydrocortisone were analysed before treatment and 24 h-6 months after instillation of each drug into the round window (RW) niche, where the substance was left. Inner ear function was determined by repeated auditory brainstem recordings (ABR). All cochleae were analysed morphologically at
M, Anniko +3 more
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Inner ear perfusion and the role of round window patency.
The American journal of otology, 1998The goal of this investigation was to evaluate the degree of round window membrane obstruction in the native state. The implications for the perfusion of the inner ear via the intratympanic instillation of medications are addressed.This was a retrospective chart review and a prospective intraoperative observation in the setting of an outpatient office ...
H, Silverstein +3 more
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Analysis of Gentamicin Kinetics in Fluids of the Inner Ear with Round Window Administration
Otology & Neurotology, 2002That a theoretical basis for quantifying drug distribution in the inner ear with local applications can be established.As methods of local drug delivery to the inner ear gain wider clinical acceptance it becomes important to establish how drugs are distributed in the ear as a function of time and for different delivery methods.The time course of ...
Stefan K R, Plontke +2 more
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Inner Ear Impedance (Cat) Determined by Time-Averaged Holography of the Round Window
The Journal of the Acoustical Society of America, 1971After amputation of the middle ear, a small closed system was built over the oval window, isolating it from the round window. Sound pressures applied to the stapes footplate were monitored by a probe microphone placed with its opening a few millimeters above the footplate.
Shyam M. Khanna, Juergen Tonndorf
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T cell subsets in round window membrane after middle ear immunostimulation.
Acta oto-laryngologica. Supplementum, 1992In secondary middle ear immune response, kinetics of immunocytes, especially T cell subsets, was examined in the round window membrane (RWM) using immunohistochemical methods. Healthy BALB/c mice and keyhole limpet hemocyanin (KLH) antigen were employed in this study.
M, Takahashi, N, Kanai
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