Results 71 to 80 of about 697,629 (282)

Isosorbide Concentration in Perilymph of the Guinea Pig After Oral Administration Versus That After Round Window Perfusion [PDF]

Clinical and Experimental Otorhinolaryngology, 2014
ObjectivesThe aims of this study were to investigate the feasibility of isosorbide delivery into perilymph through the round window membrane (RWM), and to compare the intracochlear isosorbide concentration in perilymph after oral administration (PO ...
Minbum Kim, Kyung Hee Do, Kyu-Sung Kim
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Directional sensitivity of bone conduction stimulation on the otic capsule in a finite element model of the human temporal bone

Scientific Reports
Sound transmission to the human inner ear by bone conduction pathway with an implant attached to the otic capsule is a specific case where the cochlear response depends on the direction of the stimulating force.
Paweł Borkowski
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Rotting bandits are not harder than stochastic ones [PDF]

, 2019
In stochastic multi-armed bandits, the reward distribution of each arm is assumed to be stationary. This assumption is often violated in practice (e.g., in recommendation systems), where the reward of an arm may change whenever is selected, i.e., rested ...
Carpentier, Alexandra, Lazaric, Alessandro, Locatelli, Andrea, Seznec, Julien, Valko, Michal   +4 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Issues in multi-media information networks [PDF]

, 1986
In an integrated service environment, where users exchange various types of aural and visual information, networks should appear friendly to its users providing tools for management of multi-media information.
Suda, Tatsuya
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

SENSORINEURAL HEARING LOSS IN CHRONIC SUPPURATIVE OTITIS MEDIA

The Iraqi Journal of Medical Sciences, 2016
Background:Chronic suppurative otitis media is a common disease affecting young age group, it is typically a persistent disease, often capable of causing severe destruction and irreversible sequelae and clinically manifest with deafness and discharge ...
Adil N Razooqi, Salim AH, Raed AS
doaj   +4 more sources

Identification of parameters in amplitude equations describing coupled wakes

, 1996
We study the flow behind an array of equally spaced parallel cylinders. A system of Stuart-Landau equations with complex parameters is used to model the oscillating wakes. Our purpose is to identify the 6 scalar parameters which most accurately reproduce
Albarède, Brandt, Bryson, Bunks, Chaté, Chauve, Chavent, Crutchfield, Dušek, Farmer, Farmer, Gershenfeld, Gill, Guckenheimer, Hertz, JoséMaría Fullana, Le Gal, Le Gal, Maurice Rossi, Max, Monkewitz, Patrice Le Gal, Provansal, Rothman, Rumelhart, Strogatz, Stéphane Zaleski, Willaime   +27 more
core   +1 more source