Results 71 to 80 of about 92,906 (291)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Anatomical Study of the Facial Recess with Implications in Round Window Visibility for Cochlear Implantation: Personal Observations and Review of the Literature

International Archives of Otorhinolaryngology, 2019
Introduction Posterior tympanotomy through facial recess (FR) is the conventional and most preferred approach to facilitate cochlear implantation, especially when the electrode is inserted through the round window.
Shraddha Jain, PT Deshmukh, Pooja Lakhotia, Sanika Kalambe, Deepshikha Chandravanshi, Mohnish Khatri   +5 more
doaj   +1 more source

Optical properties of the human round window membrane

, 2017
Optical techniques are effective tools for diagnostic applications in medicine and are particularly attractive for the noninvasive analysis of biological tissues and fluids in vivo.
Detemple, Daphne, Lyutenski, Stefan, Roth, Bernhard, Leuteritz, Georg, Höhl, Martin, Schmitt, Heike Andrea, Meinhardt-Wollweber, Merve, Lenarz, Thomas, Morgner, Uwe, Varkentin, Arthur   +9 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Middle ear biofilm and sudden deafness - a light and transmission electron microscopy study

Frontiers in Neurology
BackgroundThere still exists controversy about whether the healthy human middle ear mucosa is sterile or if it may harbor a diverse microbiome. Considering the delicacy of the human round window membrane (RWM), different mechanisms may exist for avoiding
Hao Li, Karin Staxäng, Hanif M. Ladak, Hanif M. Ladak, Hanif M. Ladak, Sumit Agrawal, Sumit Agrawal, Sumit Agrawal, Helge Rask-Andersen   +8 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Analysis of a Dynamic Response of the Cochlea Using Fluid-Structure Interaction Model

Engineering Transactions, 2016
A one-dimensional (1D) model of the cochlea of the inner ear has been built and validated against the previously built three-dimensional (3D) fluid-structure interaction (FSI) model of the cochlea.
Konrad KAMIENIECKI, Janusz PIECHNA, Paweł BORKOWSKI   +2 more
doaj   +1 more source

Complications after round window vibroplasty

, 2019
Purpose: To evaluate the complication rate in adult subjects with open cavities, implanted with the Vibrant Soundbridge (VSB) implant, using the round window (RW) vibroplasty procedure.
Chiara Filippi, Maurizio Barbara, Edoardo Covelli, Luigi Volpini, Martina Romeo, Simonetta Monini   +5 more
core   +1 more source

Occurence of a round window membrane rupture in patients with sudden sensorineural hearing loss [PDF]

, 2012
BACKGROUND: Aim of the present study was to evaluate the occurence of a round window membrane rupture and the effects of hearing restoration after exploratory tympanotomy and sealing of the round window (niche) in patients with unilateral sudden deafness.
Vielsmeier, Veronika, Rohrmeier, Christian, Sturtz, Jürgen, Christian Rohrmeier, Koch, Christoph, Frank Haubner, Strutz, Jürgen, Tobias Kleinjung, Veronika Vielsmeier, Christoph Koch, Haubner, Frank, Kleinjung, Tobias, Jürgen Strutz   +12 more
core   +1 more source