Results 31 to 40 of about 27,399 (256)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Impact of Groove Manufacturing Errors on Aircraft Skin-Friction Reduction

Aerospace
This study systematically investigates the effects of manufacturing errors on the drag reduction performance of micro-grooves fabricated using roll-to-roll hot embossing technology.
Zhaoliang Dou, Yue Du, Fengbin Liu
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Lost-minimum post-training parameter quantization method for convolutional neural network

Tongxin xuebao, 2022
To solve the problem that that no dataset is available for model quantization in data-sensitive scenarios, a model quantization method without using data sets was proposed.Firstly, according to the parameters of batch normalized layer and the ...
Fan ZHANG, Yun HUANG, Zizhuo FANG, Wei GUO   +3 more
doaj   +2 more sources

Implementation of a Low-Cost Navigation System Using Data Fusion of a Micro-Electro-Mechanical System Inertial Sensor and an Ultra Short Baseline on a Microcontroller

Sensors
In this work, a low-cost low-power navigation solution for autonomous underwater vehicles is introduced utilizing a Micro-Electro-Mechanical System (MEMS) inertial sensor and an ultra short baseline (USBL) system.
Julian Winkler, Sabah Badri-Hoeher
doaj   +1 more source

Addressing limited weight resolution in a fully optical neuromorphic reservoir computing readout

Scientific Reports, 2021
Using optical hardware for neuromorphic computing has become more and more popular recently, due to its efficient high-speed data processing capabilities and low power consumption. However, there are still some remaining obstacles to realizing the vision
Chonghuai Ma, Floris Laporte, Joni Dambre, Peter Bienstman   +3 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

A Note on the Perturbation of arithmetic expressions

مجلة بغداد للعلوم, 2016
In this paper we present the theoretical foundation of forward error analysis of numerical algorithms under;• Approximations in "built-in" functions.• Rounding errors in arithmetic floating-point operations.• Perturbations of data.The error analysis is ...
Baghdad Science Journal
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source