Results 51 to 60 of about 27,076 (290)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Impact of Groove Manufacturing Errors on Aircraft Skin-Friction Reduction
AerospaceThis study systematically investigates the effects of manufacturing errors on the drag reduction performance of micro-grooves fabricated using roll-to-roll hot embossing technology.
Zhaoliang Dou, Yue Du, Fengbin Liu
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Lost-minimum post-training parameter quantization method for convolutional neural network
Tongxin xuebao, 2022 To solve the problem that that no dataset is available for model quantization in data-sensitive scenarios, a model quantization method without using data sets was proposed.Firstly, according to the parameters of batch normalized layer and the ...
Fan ZHANG +3 more
doaj +2 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
A Note on the Perturbation of arithmetic expressions
مجلة بغداد للعلوم, 2016 In this paper we present the theoretical foundation of forward error analysis of numerical algorithms under;• Approximations in "built-in" functions.• Rounding errors in arithmetic floating-point operations.• Perturbations of data.The error analysis is ...
Baghdad Science Journal
doaj +1 more source
Addressing limited weight resolution in a fully optical neuromorphic reservoir computing readout
Scientific Reports, 2021 Using optical hardware for neuromorphic computing has become more and more popular recently, due to its efficient high-speed data processing capabilities and low power consumption. However, there are still some remaining obstacles to realizing the vision
Chonghuai Ma +3 more
doaj +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Randomized Low Rank Matrix Approximation: Rounding Error Analysis and a Mixed Precision Algorithm [PDF]
, 2022 The available error bounds for randomized algorithms for computing a low rank approximation to a matrix assume exact arithmetic. Rounding errors potentially dominate the approximation error, though, especially when the algorithms are run in low precision
Connolly, Michael P. +2 more
core
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source