Results 71 to 80 of about 602,649 (335)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Influence of process variables on the properties of simvastatin self-emulsifying granules obtained through high shear wet granulation [PDF]

, 2015
Improvements of the oral bioavailability of lipophilic drugs can be obtained using lipidic formulations such as the self-emulsifying drug delivery systems.
Benda L., FRANCESCHINIS, ERICA, Perssutti B., REALDON, NICOLA, SANTOMASO, ANDREA CLAUDIO, Voinovich D.   +5 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Shapes and Shears, Stars and Smears: Optimal Measurements for Weak Lensing [PDF]

, 2001
We present the theoretical and analytical bases of optimal techniques to measure weak gravitational shear from images of galaxies. We first characterize the geometric space of shears and ellipticity, then use this geometric interpretation to analyse ...
Bonnet H., G. M. Bernstein, Kuijken K., Lombardi M., M. Jarvis, Mould J., Schneider P., Smail I., Valdes F., Van Waerbeke L., Wilson G.   +10 more
core   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Modeling of the race roundness and roughness for ball bearing based on Fourier series and fractal theory

Results in Engineering
In the modeling and simulation of bearing dynamics, the roundness profile and surface roughness of the raceway is critical for ensuring the precision of the simulation results.
Long He, Fan Yang, Zhaorong Li, Jianping Yan, Diwang Ruan   +4 more
doaj   +1 more source

Evaluation of Wear between Pin and Bush in Roller Chain

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2009
A roller chain is a typical machine element used in bicycles, motorcycles and many other devices for power transmission. The life of a roller chain is determined by elongation.
Shoji NOGUCHI, Hideaki YOSHIBA, Satoshi NAKAYAMA, Tohru KANADA   +3 more
doaj   +1 more source

Ancient Aeolian Reservoirs of the East Siberia Craton

Geosciences, 2023
Fine-grained strata deposited on the Eastern Siberian craton are predominantly considered to mainly consist of Neoproterozoic sandstones. Clastic rocks near the unconformity border of the Ediacaran and the Riphean are represented by sandstone and ...
Michail V. Shaldybin, Svetlana Kvachko, Maxim Rudmin, Alexey Plyusnin, Iliya Kuznetsov   +4 more
doaj   +1 more source

Cyber equipping 4.0 – fe-simulation-based setting instructions for a rotary draw-bending machine [PDF]

, 2017
The tool setting process for rotary draw-bending is very complex. Only experienced machine operators know which settings lead to a good result in relation to the bending task.
Abele, Darwin, Engel, Bernd, Hoffmann, Sven, Kuhnhen, Christopher, Pinatti de Carvalho, Aparecido Fabiano, Schulte, Linda, Schweitzer, Marcus, Wulf, Volker   +7 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source