Results 41 to 50 of about 807,343 (265)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Les documents de transport de marchandises par route à l’épreuve du droit OHADA [PDF]
Mouvements et Enjeux Sociaux, 2023 Le contrat de transport de marchandises est juridiquement formé dès l’échange des consentements entre le transporteur et l’expéditeur et sa validité est subordonnée à l’établissement d’un écrit ou d’un document.
Elie NGUEJI NGUEJI
doaj
Collision Avoidance Path Planning for Vehicles Combining MPC and CACC Controllers
IEEE Access, 2023 The vehicle collision avoidance system has problems such as poor emergency collision avoidance ability and susceptibility to noise interference. Therefore, this study adopts a vehicle tracking model that integrates dynamic constraints and a two car ...
Qingde Zeng, Bin Liu
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
The Correlation between CYP450 Ile462Val Polymorphism and Prostate Cancer in a Group of Iranian Men
Middle East Journal of Cancer, 2016 Background: Cytochrome P450 plays an important role in pharmaceutical metabolism, steroidal hormones and procarcinogens. CYP1A1 is an enzyme, which is very active in the formation of reactive mediators or injurious agents for DNA.
Maryam Seydali Route +1 more
doaj
Low-carbon green development path and practice of the iron and steel industry
工程科学学报, 2023 Coping with climate change is a common topic facing the world. The steel industry is an important basic industry of the national economy; however, it is also a resource-intensive and typical high-carbon-emission industry.
Yiren LI +3 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
THEORETICAL JUSTIFICATION OF EXPONENTIAL DISTRIBUTION LAW OF DISTANCES BETWEEN STOPS OF CITY PUBLIC TRANSPORT [PDF]
Avtomobilʹnyj Transport (Harʹkov), 2012 The paper presents the results of investigation of relation bitween the trip distance on stops location on the route between places of attraction. Theoretical justification of the use fulness of exponential distribution with the shift parameter for ...
Gorbachov, P. +2 more
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source