Results 41 to 50 of about 1,478,859 (296)
The strategy of passenger transportation by national railway transport: the implementation of public service obligations [PDF]
Transport, 2009 Based on research carried out by the author, the article identifies the problems of passenger transportation by national railway transport such as reduction in passenger flows, the growth of transportation costs, insufficient financing of loss-making ...
J. Butkevičius
doaj +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2021 Have you ever used the route search function? Most of you have probably used the route search function that comes with map applications such as Google Maps, Apple Maps, and Open Street Map at least once.
Masaya, Misaizu
core
Constraints on Tourism Development Caused by the Road Network in the Apuseni Mountains [PDF]
Romanian Review of Regional Studies, 2015 A well-developed road network constitutes an asset for tourism development in any given region. However, the presence of these roads is not in itself a guarantee of a high level of accessibility and connectivity to the tourism resources.
MAGDALENA DRĂGAN, GABRIELA COCEAN
doaj
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
REORGANIZATION OF THE TECHNOLOGICAL FLOW AT CLOTHING COMPANY THROUGH THE PRODUCTION SCHEDULE [PDF]
Annals of the University of Oradea: Fascicle of Textiles, Leatherwork, 2017 One of the main difficulties that light industry, namely clothing manufacturing sector faces today is inadequate organization of production processes. This is one of the most common and most serious obstacles in companies in the country, leading to low ...
GHELBET Angela +3 more
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Sensors, 2014 Mobile security is one of the most fundamental problems in Wireless Sensor Networks (WSNs). The data transmission path will be compromised for some disabled nodes.
Wenzhong Guo +4 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source