Results 61 to 70 of about 3,803,647 (352)

Charisma and Routine: Shaping the Memory of Brother Richard and Joan of Arc

open access: yesReligions, 2012
The extraordinary life and fate of Joan of Arc are well known; so is her association with the prophetic preacher, Brother Richard, who predicted the Apocalypse. Less well explained is why contemporaries initially took such an interest in this association,
Andrew Brown
doaj   +1 more source

Modeling the Structure and Complexity of Engineering Routine Design Problems [PDF]

open access: yes, 2011
This paper proposes a model to structure routine design problems as well as a model of its design complexity. The idea is that having a proper model of the structure of such problems enables understanding its complexity, and likewise, a proper ...
Houten, F.J.A.M. van   +2 more
core   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Technology and Meditation: Exploring the Challenges and Benefits of a Physical Device to Support Meditation Routine

open access: yesMultimodal Technologies and Interaction
Existing studies of technology supporting meditation habit formation mainly focus on mobile applications which support users via reminders. A potentially more effective source of motivation could be contextual cues provided by meaningful objects in ...
Tjaša Kermavnar, Pieter M. A. Desmet
doaj   +1 more source

Micro-meso-macro practice tensions in using patient-reported outcome and experience measures in hospital palliative care [PDF]

open access: yes, 2018
This article applies a micro-meso-macro analytical framework to understand clinicians’ experiences and perspectives of using patient-reported outcome and experience measures (PROMs and PREMs) in routine hospital-based palliative care.
Cohen, Robin   +7 more
core   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

The Frequency of Episiotomy and Its Related Factors

open access: yesنشریه پرستاری ایران, 2012
Background and purpose: Despite routine episiotomy is questioned in specialized midwifery books for more than a decade , this method is still routinely performed in Iran .
Khani S, Zare K, Ramezannezhad SE
doaj  

Exploring the Daily Lives of People on Methadone Maintenance Treatment: An Occupational Perspective

open access: yesSocieties, 2016
A qualitative study was undertaken with five people on methadone maintenance treatment (MMT) to better understand their experiences and daily routines.
Katrina Warren   +3 more
doaj   +1 more source

Bacterial atmospheric contamination during routine dental activity [PDF]

open access: yes, 2007
Routine dental procedures cause atmospheric bacterial contamination in the dental clinic and laboratory. This environmental hazard, quantified by the Air Microbial Index, was shown in our study to be directly related to aerosol creating instruments and ...
Debattista, Neville   +2 more
core  

Home - About - Disclaimer - Privacy