Results 71 to 80 of about 566,058 (355)

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Outlier detection based energy efficient and reliable routing protocol using deep learning algorithm

Cognitive Computation and Systems, 2023
Wireless sensor network have also played a vital role in the observation and management of agricultural land in terms of climate, water usage, crops, etc.
P. Jasmine Lizy, N. Chenthalir Indra
doaj   +1 more source

Adaptive Thermal-Aware Routing Protocol for Wireless Body Area Network

Electronics, 2019
The recent advancement in information technology and evolving of the (IoT) shifted the traditional medical approach to patient-oriented approach (e.g., Telemedicine/Telemonitoring).
Faisal Jamil, M. Iqbal, Rashid Amin, Do-Hyeun Kim   +3 more
semanticscholar   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

An Energy-Efficient and Secure Routing Protocol for Intrusion Avoidance in IoT-Based WSN

Energies, 2019
Due to the advancement of information and communication technologies, the use of Internet of Things (IoT) devices has increased exponentially. In the development of IoT, wireless sensor networks (WSNs) perform a vital part and comprises of low-cost smart
K. Haseeb, Ahmad S. Almogren, N. Islam, Ikram Ud Din, Zahoor Jan   +4 more
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

A Secure Link State Routing Protocol for NDN

IEEE Access, 2018
The Named-data Link State Routing protocol (NLSR) is a protocol for intra-domain routing in Named Data Networking (NDN). It is an application level protocol similar to many IP routing protocols, but NLSR uses NDN's interest/data packets to disseminate ...
Lan Wang, Vince Lehman, A. K. M. Mahmudul Hoque, Beichuan Zhang, Yingdi Yu, Lixia Zhang   +5 more
doaj   +1 more source

Analisa Proses Routing Ripv1, Ripv2, Ripng, antara Model Ipv4 dengan Ipv6 pada Jaringan Data PT. Pertamina Ru II Dumai [PDF]

, 2016
The development of telecommunications today make the need for communication of data quickly and efficiently is also one of his company besar.IPv4 scale to support 32-bit addressing and developed IPv6 supports up to 128 -bit addressing and also developed ...
Adhil, I. F. (Irsan), Safrianti, E. \u27. (Ery), Sari, L. O. (Linna)   +2 more
core  

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source