Results 71 to 80 of about 2,987,652 (330)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

INTRODUCTION TO ROUTING PROTOCOLS

INTERNATIONAL JOURNAL OF COMPUTERS & TECHNOLOGY, 2014
In this era of communication network, we can access any website or contact any person with the help of internet or telephone anywhere in the world without knowing where the website is hosted and without knowing where the person is located. This all is done within a few seconds very efficiently. But the question comes out how it is done?
Nikhil Kumar, Shah Singh, Sahil Kumar, Jagdeep Singh   +3 more
openaire   +3 more sources

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Strategies to reduce the cancer burden and improve access to effective and affordable cancer interventions in Europe

Molecular Oncology, EarlyView.
Comprehensive cancer centre (CCCs) and CCCs of Excellence (CCCoE) integration in healthcare. Through outreach to surrounding community hospitals, CCCs enable wider access to top‐clinical cancer treatments and care, thereby facilitating the swift enrolment of patients into data‐rich clinical trials (PI‐initiated trials testing new concepts, drug ...
Anton Berns, Ulrik Ringborg, Julio Celis, Bengt Jönsson, Michael Baumann   +4 more
wiley   +1 more source

ANALISIS PERBANDINGAN ROUTING PROTOKOL OPEN SHORTES PATH FIRST (OSPF) DENGAN ENHANCED INTERIOR GATEWAY ROUTING PROTOCOL (EIGRP)

Ilkom Jurnal Ilmiah, 2018
Routing adalah proses pemilihan rute terbaik untuk suatu paket data agar dapat sampai ke tujuannya. Proses routing sangat dibutuhkan dalam proses pengiriman  data.
Nur Indah, Yulita Salim, Ramdan Satra
doaj   +1 more source

Sigma Routing Metric for RPL Protocol [PDF]

Sensors, 2018
This paper presents the adaptation of a specific metric for the RPL protocol in the objective function MRHOF. Among the functions standardized by IETF, we find OF0, which is based on the minimum hop count, as well as MRHOF, which is based on the Expected Transmission Count (ETX). However, when the network becomes denser or the number of nodes increases,
Luis Fernández, Paul Sanmartin, Paul Sanmartin, Aldo Rojas, Karen Avila, Sebastian Valle, Daladier Jabba   +6 more
openaire   +5 more sources

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

GDP‐fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP‐fucose and fucosylated glycan synthesis

FEBS Open Bio, EarlyView.
The inactivation of SLC35C1 (GDP‐fucose transporter) and enzymes involved in GDP‐fucose biosynthesis was studied. Fucose supplementation increases the level of GDP‐fucose to abnormal, millimolar values in the absence of the TSTA3 protein and SLC35C1 in contrast to the GMDS/SLC35C1 double mutant.
Edyta Skurska, Mariusz Olczak
wiley   +1 more source

A novel energy-aware routing protocol in intermittently connected delay-tolerant wireless sensor networks

International Journal of Distributed Sensor Networks, 2017
In delay-tolerant wireless sensor networks, messages for sensor data are delivered using opportunistic contacts between intermittently connected nodes. Since there is no stable end-to-end routing path like the Internet and mobile nodes operate on battery,
Min Wook Kang, Yun Won Chung
doaj   +1 more source

Adaptive link-weight routing protocol using cross-layer communication for MANET [PDF]

, 2007
Routing efficiency is one of the challenges offered by Mobile Ad-hoc Networks (MANETs). This paper proposes a novel routing technique called Adaptive Link-Weight (ALW) routing protocol.
Al-Khwildi, AN, Al-Raweshidy, H, Khan, S, Loo, KK   +3 more
core   +1 more source