Results 61 to 70 of about 30,781 (251)

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Proteome‐Wide Target Identification Using Reactive Metallo‐Scaffolds (r‐mS): A Platform for Metallodrug Discovery

Angewandte Chemie, EarlyView.
Re‐envisioning the Ligandable Proteome: Reactive Metallo‐Scaffolds (r‐mS) combine non‐covalent protein engagement by a metallo‐scaffold with covalent cysteine capture through a tethered chloroacetamide warhead. Chemoproteomic profiling reveals unique enzyme engagement including ligases, kinases and methyltransferases, highlighting opportunities for ...
Jessica E. Waters, Harry Wilders, George S. Biggs, Mika Kintzel, Emma E. Cawood, Jonathan Bailey, Sarah Maslen, Yew Mun Yip, Mason Wakley, Ioannis G. Riziotis, Thomas W. Rees, Joanna Redmond, J. Mark Skehel, David House, Jacob Bush, Jeannine Hess   +15 more
wiley   +2 more sources

The Small Frontier: Trends Toward Miniaturization and the Future of Planetary Surface Rovers

Actuators
The robotic exploration of space began only five decades ago, and yet in the intervening years, a wide and diverse ecosystem of robotic explorers has been developed for this purpose. Such devices have greatly benefited from miniaturization trends and the
Carrington Chun, Faysal Chowdoury, Muhammad Hassan Tanveer, Sumit Chakravarty, David A. Guerra-Zubiaga   +4 more
doaj   +1 more source

Insights Into the Nature of Quantum Emitters in Electron‐Irradiated Hexagonal Boron Nitride

Advanced Science, EarlyView.
Hyperspectral imaging is used to identify quantum emitters hosted by the 2D material hexagonal boron nitride. By selecting specific emission wavelengths, one can distinguish individual emitters from ensembles and gain important insights into the atomic structure of these emitters.
Mouli Hazra, Anna Rupp, Mohammad N. Mishuk, Josefine Krause, Anand Kumar, Julien Chénedé, Mingi Kang, Bayarjargal N. Tugchin, Marijn Rikers, Isabelle Staude, Thomas Pertsch, Alexander Högele, Tobias Vogl   +12 more
wiley   +1 more source

Autonomous Navigation of a Center-Articulated and Hydrostatic Transmission Rover using a Modified Pure Pursuit Algorithm in a Cotton Field

Sensors, 2020
This study proposes an algorithm that controls an autonomous, multi-purpose, center-articulated hydrostatic transmission rover to navigate along crop rows.
Kadeghe Fue, Wesley Porter, Edward Barnes, Changying Li, Glen Rains   +4 more
doaj   +1 more source

Automated Design of Lightweight Exploration Rovers [PDF]

, 2013
In the recent years, vehicle-environment modeling techniques and powerful simulation tools have been used exhaustively to design wheeled rovers. In spite of that, rover preliminary design is still very dependent on human designer.
Schäfer, Bernd / Robotik und Mechatronik, Carvalho Leite, Alexandre   +1 more
core  

Spiegare l’errore. A proposito di alcune recenti linee di ricerca

, 2022
Il presente contributo mira a presentare e discutere in chiave critica alcuni dei nove saggi contenuti nella raccolta Axiological Confusion and Its Causes («ΠΗΓΗ / FONS Revista de estudios sobre la civilización clásica y su recepción» 5, Special Issue,
Rover, Chiara, chiara rover
core   +1 more source

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

Advanced Science, EarlyView.
Two‐photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task‐related place cell activity and splitter cell trajectory coding are impaired, with reduced retrospective dominance and greater prospective weighting.
Yimei Li, Mary Ann Go, Hualong Zhang, Robertas Aleksynas, Juliana Kim, Mingyang Gao, Seigfred Prado, Magdalena Sastre, Simon R. Schultz   +8 more
wiley   +1 more source

A Semi-Empirical State of Health Estimation Method for Batteries of Electric Vehicles Operating in Varying Real-World Conditions

IEEE Access
Present research on battery State of Health (SoH) estimation is mainly focusing on constant conditions, solely cycling conditions or solely storage conditions, whereas few attempts have been made for varying real-world conditions.
Lianfang Cai, Mark Holdstock, Manlio Valerio Morganti, Sridhar Ayyapureddi, Andrew Mcgordon   +4 more
doaj   +1 more source

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

Advanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren, Qian Yue, Ning Gao, Qiu‐Lian Hao, Yan Huo, Chuchu Li, Xinyue Leng, Lu‐Lu Sun, Maggie Pui Man Hoi, Hai‐Hao Han, Mingliang Ma, Xu‐Wen Li   +11 more
wiley   +1 more source