Results 81 to 90 of about 3,625,328 (233)

The value of ROX index in predicting the outcome of high flow nasal cannula: a systematic review and meta-analysis

Respiratory Research, 2022
Background High flow nasal cannula (HFNC) therapy is widely employed in acute hypoxemic respiratory failure (AHRF) patients. However, the techniques for predicting HFNC outcome remain scarce.
Zhen Junhai, Yan Jing, Cao Beibei, Li Li
doaj   +1 more source

High-Flow Nasal Cannula for COVID-19 Patients: A Multicenter Retrospective Study in China

Frontiers in Molecular Biosciences, 2021
Background: High-flow nasal cannula (HFNC) may help avoid intubation of hypoxemic patients suffering from COVID-19; however, it may also contribute to delaying intubation, which may increase mortality.
Jun Duan, Jia Zeng, Jia Zeng, Puyu Deng, Zhong Ni, Rongli Lu, Wenxi Xia, Guoqiang Jing, Xiaoping Su, Stephan Ehrmann, Wei Zhang, Wei Zhang, Jie Li   +12 more
doaj   +1 more source

Systematic Position Mapping of Split CRISPR‐Cas12a Activators Enables Highly Sensitive miRNA Detection and Cancer Cell Stratification

Advanced Science, EarlyView.
ABSTRACT Amplification‐free Cas12a diagnostics with split crRNA enable rapid and programmable target recognition, yet insufficient understanding of DNA activator architecture prevents predictable control over trans‐cleavage activity and sensitivity. Here we systematically map over 200 split DNA activator configurations by introducing nicks at every ...
Xiaoyan Tang, Zhe Li, Yuning Lu, Miao Ma, Zijian Mo, Jiajun Ke, Xinyu Luan, Tiangang Luan, Junqiu Zhai   +8 more
wiley   +1 more source

Ratio of oxygen saturation index for predicting high-flow nasal cannula outcomes in emergency department for COVID-19 patients with severe hypoxemia: A retrospective study

Turkish Journal of Emergency Medicine
OBJECTIVES: High-flow nasal cannula (HFNC) oxygen therapy has been used as an initial ventilatory support for coronavirus disease 2019 (COVID-19) patients with mixed levels of acute hypoxemic respiratory failure (AHRF). However, the effectiveness of HFNC
Cynthia Karam, Ahmad Oseili, Fadia M Shebbo, Mohamad Fakih, Mohamad F El-Khatib   +4 more
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

The ROX, shock and diastolic shock indexes in the prediction of mortality in COVID-19

Bratislava Medical Journal
The aim of this study is to determine the role of Respiratory Rate Oxygenation (ROX), shock, and diastolic shock indexes ​​in predicting mortality in coronavirus disease 2019 (COVID-19) patients admitted to the emergency department.The COVID-19 spread worldwide in a short time and caused a major pandemic. The ROX, shock, and diastolic shock indexes are
Serdal, Ates, Mehmet, Okumus, Erdal, Demirtas, Yahya Kemal, Gunaydin, Sertac, Guler   +4 more
openaire   +2 more sources

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Comparison of cut-off points and ROC curves between ROX index at initiation and after 1 hour of HFNC.

, 2022
Comparison of cut-off points and ROC curves between ROX index at initiation and after 1 hour of HFNC.
Juvel Taculod (4114804), Juliet Tolentino Sahagun (12463080), Duu Wen Sewa (9013499), Meiying Chew (12463092), Yew Woon Chia (12463089), Chee Kiang Tay (12463086), Jonathan Jit-Ern Tan (12463104), Vicky Ng (12463074), Matthew Edward Cove (4476802), Kollengode Ramanathan (8123513), Andrew Li (411246), Kay Choong See FCCP (12463107), Amit Kansal (12463077), Sennen J. W. Lew (12463095), Ser Hon Puah (11270610), Addy Yong-Hui Tan (12463083), Qiao Li Tan (9013505), Amartya Mukhopadhyay (4114801), Shekhar Dhanvijay (12463101), Jason Phua (52085), Shirley Goh (12463098)   +20 more
core   +1 more source

Co‐Infection of Brucella canis and Brucella melitensis in a Domestic Dog With Zoonotic Transmission to Human, China

Animal Research and One Health, EarlyView.
Source attribution figure for human and dogs Brucella canis infections. ABSTRACT We report a rare occurrence of genetic material from both Brucella canis and B. melitensis detected in a domesticated dog from Jiangsu Province, China. The detection was confirmed through serological assays, quantitative PCR (qPCR), metagenomic and genomic sequencing ...
Shengxin Ge, Jian Xu, Qingchun Shen, Jiabo Ding, Xiaowen Yang   +4 more
wiley   +1 more source

Diagnostic performance of the ROX index compared with that of other respiratory parameters in determining HFNC failure.

, 2023
Diagnostic performance of the ROX index compared with that of other respiratory parameters in determining HFNC failure.
Todspol Lertwattanachai (16412797), Konlawij Trongtrakul (12629744), Pruchwilai Nuchpramool (16412791), Piyarat Phairatwet (16412794), Sujaree Poopipatpab (8930363)   +4 more
core   +1 more source