Results 71 to 80 of about 1,950 (155)

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

Drug Testing and Analysis, Volume 18, Issue 4, Page 458-482, April 2026.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

Data_Sheet_1_Safety and Efficacy of Roxadustat for Anemia in Patients With Chronic Kidney Disease: A Meta-Analysis and Trial Sequential Analysis.docx

, 2021
Background: Roxadustat, a hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI), has been used to treat anemia in patients with chronic kidney disease (CKD).
Xiaodong Geng (10741677), Xiangmei Chen (139185), Jiawei Jiang (3413531), Chengcheng Song (10983601), Zhi Mao (715678), Quan Hong (411103), Guannan Sun (656336), Guangyan Cai (141899), Chao Liu (43092), Xuefeng Sun (408801), Zhangning Fu (11358024), Kun Chi (10741680)   +11 more
core   +1 more source

Short-term effect of low-dose roxadustat combined with erythropoiesis-stimulating agent treatment for erythropoietin-resistant anemia in patients undergoing maintenance hemodialysis

Frontiers in Endocrinology
BackgroundErythropoietin resistance is present in some patients with chronic kidney disease, especially in those undergoing hemodialysis, and is often treated using roxadustat rather than iron supplements and erythropoiesis-stimulating agents (ESAs ...
Qiaoying Xu, Qiaoying Xu, Jingjing Huang, Qingzhen Liu, Qingzhen Liu, Xueling Wang, Xueling Wang, Haiying Liu, Haiying Liu, Yan Song, Yan Song, Fulin Dou, Fulin Dou, Shasha Lv, Shasha Lv, Gang Liu, Gang Liu, Gang Liu   +17 more
doaj   +1 more source

Roxadustat attenuates heat stress-induced apoptosis and senescence in renal tubular epithelial cells by upregulating HIF-1α

陆军军医大学学报
Objective To investigate the effect and underlying mechanism of roxadustat on apoptosis and senescence of renal tubular epithelial cell line HK-2 induced by heat stress.
SONG Yongwei, WANG Ling, CHEN Wenting
doaj   +1 more source

Roxadustat Versus Daprodustat for Management of Anaemia in Chronic Kidney Disease

Introduction: Anaemia is a frequent complication of chronic kidney disease (CKD) that significantly impacts morbidity, quality of life, and cardiovascular outcomes.
Muhammad Abul Hasnat, Emran Hossain, Muntasir Mamun, Samir Kumar Hore   +3 more
core   +1 more source

Assessment of the safety of Roxadustat for cardiovascular events in chronic kidney disease-related anemia using meta-analysis and bioinformatics

Frontiers in Pharmacology
ObjectiveThis study compares the cardiovascular risk in anemic chronic kidney disease patients treated with Roxadustat versus erythropoietin stimulating agents (ESAs).
Xiangmeng Li, Xiangmeng Li, Xiangmeng Li, Shimin Jiang, Xia Gu, Xia Gu, Xiaojing Liu, Xiaojing Liu, Shunlai Shang, Jiao Zhang, Keying Pang, Wenge Li, Wenge Li   +12 more
doaj   +1 more source

Roxadustat Attenuates Adverse Remodeling Following Myocardial Infarction in Mice

Activation of the CXCL12/CXCR4/ACKR3 axis is known to aid myocardial repair through ischemia-triggered hypoxia-inducible factor-1α (HIF-1α).
Marc-Michael Zaruba, Simon Staggl, Vivek Jeyakumar, Santhosh Kumar Ghadge, Patric Schönherr, Gerhard Pölzl, Moritz Messner, Andreas Wimmer, Thomas Maurer, Axel Bauer, Jasmina Gavranovic-Novakovic   +10 more
core   +1 more source

Cardiovascular and renal safety outcomes of hypoxia-inducible factor prolyl-hydroxylase inhibitor roxadustat for anemia patients with chronic kidney disease: a systematic review and meta-analysis

Renal Failure
This systematic review and meta-analysis were conducted to evaluate the cardiac and kidney-related adverse effects of roxadustat for the treatment of anemia in CKD patients. 18 trials with a total of 8806 participants were identified for analysis.
Lei Tian, Mengdi Wang, Mengchao Liu, Yanyu Pang, Jingwen Zhao, Bingjie Zheng, Yutong Wang, Wenjing Zhao   +7 more
doaj   +1 more source

EFFICACY OF ROXADUSTAT IN CHRONIC KIDNEY DISEASE PATIENTS NOT ON DIALYSIS WITH ANEMIA: SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

Hematology, Transfusion and Cell Therapy
Objective: Anemia is a common complication in patients with Chronic Kidney Disease (CKD), particularly in those not receiving dialysis. Roxadustat, a Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor (HIF-PHI), has been investigated as a therapeutic ...
Lokman Hekim Tanriverdi, Ayşe Uysal, Arzu Akyay, Yurday Öncül, Ahmet Sarici   +4 more
doaj   +1 more source

Efficacy and Safety of Roxadustat in Patients with CKD: Pooled Analysis by Baseline Inflammation Status

Background/Objectives: Inflammation may contribute to hyporesponsiveness to erythropoiesis-stimulating agents (ESAs) and is often present in patients with chronic kidney disease (CKD).
Vicki Santos, Harkavyi, Alexander, Gabriel Choukroun, Alina Jiletcovici, Strutz, Frank, Santos, Vicki, Lucia Del Vecchio, del Vecchio, Lucia, Alexander Harkavyi, Choukroun, Gabriel, Frank Strutz, Jiletcovici, Alina   +11 more
core   +1 more source