Results 1 to 10 of about 3,146,264 (297)

Exploring medical students’ perceptions of the challenges and benefits of volunteering in the intensive care unit during the COVID-19 pandemic: a qualitative study

BMJ Open, 2021
Objectives In March 2020, the WHO declared SARS-CoV-2 a pandemic. Hospitals across the world faced staff, bed and supply shortages, with some European hospitals calling on medical students to fill the staffing gaps.
Seamus Sreenan, Arnold Hill, Aliya Ali, Marita Staunton, Adam Quinn, Gordon Treacy, Patrick Kennelly, Marian Brennan   +7 more
doaj   +1 more source

The Pharmacological Effects of Plant-Derived versus Synthetic Cannabidiol in Human Cell Lines

Medical Cannabis and Cannabinoids, 2021
Introduction: Cannabidiol (CBD) can be isolated from Cannabis sativa L. or synthetically produced. The aim of this study was to compare the in vitro effects of purified natural and synthetic CBD to establish any pharmacological differences or superiority
Ryan F. Maguire, Daniel J. Wilkinson, Timothy J. England, Saoirse E. O’Sullivan   +3 more
doaj   +1 more source

Osteokines and the vasculature: a review of the in vitro effects of osteocalcin, fibroblast growth factor-23 and lipocalin-2 [PDF]

PeerJ, 2019
Bone-derived factors that demonstrate extra-skeletal functions, also termed osteokines, are fast becoming a highly interesting and focused area of cross-disciplinary endocrine research. Osteocalcin (OCN), fibroblast growth factor-23 (FGF23) and lipocalin-
Sophie A. Millar, Susan I. Anderson, Saoirse E. O’Sullivan   +2 more
doaj   +2 more sources

An Investigation Into the Role of Osteocalcin in Human Arterial Smooth Muscle Cell Calcification

Frontiers in Endocrinology, 2020
Osteocalcin (OCN) is a bone-derived protein that is detected within human calcified vascular tissue. Calcification is particularly prevalent in chronic kidney disease (CKD) patients but the role of OCN in calcification, whether active or passive, has not
Sophie A. Millar, Stephen G. John, Christopher W. McIntyre, Christopher W. McIntyre, Vera Ralevic, Susan I. Anderson, Saoirse E. O'Sullivan   +6 more
doaj   +1 more source

Osteocalcin, Vascular Calcification, and Atherosclerosis: A Systematic Review and Meta-analysis

Frontiers in Endocrinology, 2017
BackgroundOsteocalcin (OC) is an intriguing hormone, concomitantly being the most abundant non-collagenous peptide found in the mineralized matrix of bone, and expanding the endocrine function of the skeleton with far-reaching extra-osseous effects.
Sophie A. Millar, Hinal Patel, Susan I. Anderson, Timothy J. England, Saoirse E. O’Sullivan   +4 more
doaj   +1 more source

Factors Associated With Change in Skin Autofluorescence, a Measure of Advanced Glycation End Products, in Persons Receiving Dialysis

Kidney International Reports, 2020
Introduction: An increase over time in skin autofluorescence (SAF), a measure of accumulation of advanced glycation end products (AGE), predicts higher mortality on hemodialysis (HD).
Daniela Viramontes Hörner, Nicholas M. Selby, Maarten W. Taal   +2 more
doaj   +1 more source

Closing the gap: a transatlantic collaboration to foster quality improvement training in graduate entry medical students using applications of QI methodologies to medical education

BMJ Open Quality, 2019
The alarming prevalence of medical error and adverse events in the health system raises a call to action to ensure that doctors in training receive adequate training in quality improvement (QI).
Allison Brown, Seamus Sreenan, Alice McGarvey   +2 more
doaj   +1 more source

Selective oestrogen receptor antagonists inhibit oesophageal cancer cell proliferation in vitro

BMC Cancer, 2018
Background Oestrogen receptors (ER) have a well-established role to the initiation, progression and regulation of responses to treatment of breast, prostate, and lung cancers.
Waleed Al-Khyatt, Cristina Tufarelli, Raheela Khan, Syed Yousef Iftikhar   +3 more
doaj   +1 more source

Over prescribing of antibiotics for acute respiratory tract infections; a qualitative study to explore Irish general practitioners’ perspectives

BMC Family Practice, 2019
Background Anti-microbial resistance (AMR) is a global threat to public health and antibiotics are often unnecessarily prescribed for acute respiratory tract infections (ARTIs) in general practice.
Jane O’Doherty, Leonard F. W. Leader, Andrew O’Regan, Colum Dunne, Soorej Jose Puthoopparambil, Raymond O’Connor   +5 more
doaj   +1 more source

A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans

Frontiers in Pharmacology, 2018
Background: Cannabidiol is being pursued as a therapeutic treatment for multiple conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but literature in humans is not sufficient.
Sophie A. Millar, Nicole L. Stone, Andrew S. Yates, Saoirse E. O'Sullivan   +3 more
doaj   +1 more source