Results 21 to 30 of about 3,146,264 (297)

Community challenges when using large plastic bottles for Solar Energy Disinfection of Water (SODIS)

BMC Public Health, 2016
Background Communities living in developing countries as well as populations affected by natural or man-made disasters can be left at great risk from water related diseases, especially those spread through the faecal-oral route.
Preeti Borde, Khalifa Elmusharaf, Kevin G. McGuigan, Michael B. Keogh   +3 more
doaj   +1 more source

Exploration of GP perspectives on deprescribing antidepressants: a qualitative study

BMJ Open, 2021
Objective Our aim was to explore general practitioners’ (GPs) perceptions and experiences of discontinuing antidepressants.Study design A qualitative study using semistructured interviews was undertaken between July 2019 and March 2020.
Liam Glynn, Peter Hayes, Dervla Kelly, Justin Graffi, Maria Noonan, Philip Green   +5 more
doaj   +1 more source

Impact of accelerated, graduate-entry medicine courses: a comparison of profile, success, and specialty destination between graduate entrants to accelerated or standard medicine courses in UK

BMC Medical Education, 2018
Background Little research has compared the profile, success, or specialty destinations of graduates entering UK medical schools via accelerated, 4-yr, standard 5-yr and 6-yr programmes.
Paul Garrud, I. C. McManus
doaj   +1 more source

Transcriptomic meta‐analysis of disuse muscle atrophy vs. resistance exercise‐induced hypertrophy in young and older humans

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background Skeletal muscle atrophy manifests across numerous diseases; however, the extent of similarities/differences in causal mechanisms between atrophying conditions in unclear.
Colleen S. Deane, Craig R.G. Willis, Bethan E. Phillips, Philip J. Atherton, Lorna W. Harries, Ryan M. Ames, Nathaniel J. Szewczyk, Timothy Etheridge   +7 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Patterns and determinants of pathways to reach comprehensive emergency obstetric and neonatal care (CEmONC) in South Sudan: qualitative diagrammatic pathway analysis

BMC Pregnancy and Childbirth, 2017
Background Maternity referral systems have been under-documented, under-researched, and under-theorised. Responsive emergency referral systems and appropriate transportation are cornerstones in the continuum of care and central to the complex health ...
Khalifa Elmusharaf, Elaine Byrne, Ayat AbuAgla, Amal AbdelRahim, Mary Manandhar, Egbert Sondorp, Diarmuid O’Donovan   +6 more
doaj   +1 more source

The Inaugural Australian Centre for Hepatitis Virology Public Panel Discussion on Viral Hepatitis Research—Lessons in Scientific Community Outreach

Viruses, 2021
Viral hepatitis remains one of the most significant health issues globally, directly responsible for over 1 million deaths each year and affecting almost 300 million people around the world.
Thomas Tu, Chaturaka Rodrigo, Simone I Strasser, D Scott Bowden, Jennifer H MacLachlan, Heidi E Drummer   +5 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

The impact of JUUL market entry on cigarette sales: evidence from a major chain retailer in Canada

Harm Reduction Journal, 2023
Background Electronic nicotine delivery systems (ENDS), such as the JUUL system, are nicotine products for adults who currently smoke cigarettes but are looking for an alternative to combustible cigarettes.
Yingying Xu, Anindya Sen, Tengjiao Chen, Christopher M. Harris, Shivaani Prakash   +4 more
doaj   +1 more source