Results 31 to 40 of about 67,204 (291)

Comparative study of experimental and computational procedures for the calculation of molecular lipophilicity

Saúde & Tecnologia, 2015
Background – The lipophilicity is one of the physicochemical properties that most influences the ability of a molecule to move through biological compartments.
Gonçalo Clemente
doaj   +1 more source

Concept of ecologically acceptable chromatographic methods: Case study on the separation of dronedarone hydrochloride and its degradation products [PDF]

Arhiv za farmaciju
Recently, concern about the environmental impact of drug analysis methods has increased significantly. Reversed-phase high-performance liquid chromatography (RP-HPLC), the predominant technique in drug analysis, relies heavily on organic solvents such as
Đajić Nevena, Krmar Jovana, Stojanović Jevrem, Svrkota Bojana, Otašević Biljana, Malenović Anđelija, Protić Ana   +6 more
doaj   +1 more source

Method operable design region for robust RP-HPLC analysis of pioglitazone hydrochloride and teneligliptin hydrobromide hydrate: incorporating hybrid principles of white analytical chemistry and design of experiments

Future Journal of Pharmaceutical Sciences, 2023
Background A combination of pioglitazone hydrochloride with teneligliptin hydrobromide hydrate is used to treat type-2 diabetes. Several chromatographic techniques have been described in the literature for determination of each of these medications ...
Pintu Prajapati, Bageshree Rana, Veera Shakar Pulusu, Shailesh Shah   +3 more
doaj   +1 more source

ESTIMATION OF ONDANSETRON HYDROCHLORIDE BY RP-HPLC

EPRA International Journal of Research & Development (IJRD), 2020
A RP-HPLC method was developed for the estimation of Ondansetron Hydrochloride in Bulk drug using high performance liquid chromatography. Ondansetron was a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic drug to treat nausea and vomiting after cancer chemotherapy.
openaire   +1 more source

Cell Membrane Vesicle Camouflaged Artificial Cells

Advanced Functional Materials, EarlyView.
Artificial cells camouflaged with a cell membrane vesicle coating are able to assemble into synthetic aggregates that exhibit rudimentary communication capabilities. Additionally, when these artificial cells are equipped with antioxidant capabilities, they are able to protect the intracellular homeostasis in HepG2 cells present in semi‐synthetic ...
Paula De Dios Andres, Stefan Pendlmayr, Noga Gal, Cathrine Abild Meyer, Cecilie Ryberg, Olav Vestrheim, Noel Angelo Kalacas, Fatih Demir, Markus M. Rinschen, Karsten Haupt, Rajeshwar Prosad Mookerjee, Brigitte Städler   +11 more
wiley   +1 more source

High‐Throughput Microfluidic‐Mediated Assembly of Layer‐By‐Layer Nanoparticles

Advanced Functional Materials, EarlyView.
The layer‐by‐layer (LbL) assembly of polymer films on nanoparticle (NP) surfaces is a promising technique for targeted drug delivery. Despite its success in preclinical mouse models, a current good manufacturing practices (cGMP) compliant, clinical‐scale production method has been lacking.
Ivan S. Pires, Ezra Gordon, Heikyung Suh, Darrell J. Irvine, Paula T. Hammond   +4 more
wiley   +1 more source

Oligonucleotides Featuring a Covalently Mercurated 6‐Phenylcarbazole Residue as High‐Affinity Hybridization Probes for Thiopyrimidine‐Containing Sequences

Chemistry – A European Journal, Volume 28, Issue 69, December 9, 2022., 2022
Getting back to (nucleo)base: Oligonucleotides incorporating a central 1‐ or 8‐mercuri‐6‐phenyl‐1H‐carbazole residue show great promise as high‐affinity hybridization probes, discriminating between all canonical nucleobases as well as 2‐ and 4‐thiothymines by melting temperature margins of at least 5 °C.
Tharun K. Kotammagari, Petri Tähtinen, Tuomas Lönnberg   +2 more
wiley   +1 more source

Quality by design based ecofriendly HPLC analytical method for simultaneous quantification of erastin and lenalidomide in mesoporous silica nanoparticles

Scientific Reports
The aims of this work to optimize and validate a RP-HPLC method to quantify erastin (ERT) and lenalidomide (LND) in mesoporous silica nanoparticles (MSNs). The Design of Experiments (DoE) strategy optimized the RP-HPLC method.
Ashutosh Gupta, S. P. Rachana, Sudheer Moorkoth, Namdev Dhas   +3 more
doaj   +1 more source

DEVELOPMENT OF METHODS FOR DETERMINATION OF SPECIFIC IMPURITIES IN THE GLUTATIONION RESTORED SUBSTANCE

Фармация и фармакология (Пятигорск), 2019
Glutathione (γ-L-glutamyl-L-cysteinylglycine) is the most important low molecular weight intracellular thiol tripeptide consisting of three amino acids – glycine, cysteine and glutamic acid.
K. A. Alexeeva, D. I. Pisarev, A. Yu. Malyutina, N. N. Boyko   +3 more
doaj   +1 more source

Radiation‐Resistant Bacteria Deinococcus radiodurans‐Derived Extracellular Vesicles as Potential Radioprotectors

Advanced Healthcare Materials, EarlyView.
Deinococcus radiodurans‐derived extracellular vesicles (R1‐EVs) provide radioprotection against total‐body irradiation‐induced acute radiation syndrome in mice. R1‐EVs mitigate oxidative damage by scavenging free radicals, promoting intestinal repair, enhancing hematopoietic function, and modulating immune responses. This study highlights the potential
Jeong Moo Han, Godfrey Mwiti, Seo‐Joon Yeom, Jaeyoon Lim, Woo Sik Kim, Sangyong Lim, Seung‐Taik Lim, Eui‐Baek Byun   +7 more
wiley   +1 more source