Results 151 to 160 of about 174,858 (286)

Retinal Pigment Epitheliopathy due to Sub‐Optimal Recycling of Vitamin A (RESORVA): A Novel RDH11‐Related Phenotype

Clinical Genetics, EarlyView.
RDH11 is a minor isoenzyme that catalyses the oxidation of 11‐cis‐retinol to 11‐cis‐retinal in the retinal pigment epithelium, alongside RDH5 and RDH10. Biallelic null variants in RDH11 lead to upregulation of RDH5 and RDH10 (transcriptional adaptation), maintaining 11‐cis‐retinal bioavailability, but still causing Retinal Pigment Epitheliopathy due to
Kirk A. J. Stephenson, Zhuo Shao, Anupreet Tumber, Erika Tavares, Kashif Ahmed, Edward J. Higginbotham, Christian R. Marshall, Jason T. Maynes, Ammaji Rajala, Raju V. S. Rajala, Elise Héon, Ajoy Vincent   +11 more
wiley   +1 more source

Stage‐Associated Microglial Subpopulations and Dynamics in Vascular Pathogenesis of Oxygen‐Induced Retinopathy

Cell Proliferation, EarlyView.
In the oxygen‐induced retinopathy (OIR) mouse model, two distinct microglial subpopulations play opposing roles: highly glycolytic microglia (HGM) promote neovascular formation via Pkm2, while Mrc1/CD206‐positive phagocytosis‐associated microglia (PAM) facilitate its regression.
Yuan Ma, Ziye Chen, Baoyi Liu, Wen Ding, Runping Duan, Kangjie Kong, Zhuojun Xu, Jizhu Li, Jiali Ru, Dianlei Guo, Xiaoyue Wei, Yaping Liu, Zhuangling Lin, Yang Meng, Yuan Liu, Lan Jiang, Zitong Chen, Rebiya Tuxun, Chinling Tsai, Chunqiao Liu, Tao Li   +20 more
wiley   +1 more source

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, EarlyView.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

Evolving Congenital Hypertrophy of the Retinal Pigment Epithelium in a Pediatric Patient. [PDF]

J Vitreoretin Dis
Pan S, Lim J, Mai D, Pirouz A, Adrean SD.   +4 more
europepmc   +1 more source

Maternal and child mental health and incident migraine in adolescence: An “All Our Families” prospective cohort study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To examine the association between mental health symptoms in youth and their mothers, and youth incident migraine, using prospectively collected, longitudinal data from the “All Our Families” (AOF) cohort study. Background Internalizing mental health symptoms, such as anxiety and depression, whether experienced by a child or his/her ...
Kirsten Sjonnesen, Melanie Noel, Tamara Pringsheim, Scott B. Patten, Sheri Madigan, Prachi Khanna, Sheila McDonald, Paul E. Ronksley, Suzanne Tough, Serena L. Orr   +9 more
wiley   +1 more source

Mechanisms of Programmed Cell Death in Sodium Iodate-Driven Retinal Degeneration and the Role of DJ-1. [PDF]

Int J Mol Sci
Upadhyay M, Milliner C, Bonilha VL.
europepmc   +1 more source

The Role of NLRP1, AIM2 and MEFV Inflammasomes in the High‐Intensity Interval Training of Individuals With Obesity

Immunology, EarlyView.
This study shows that 8 weeks of high‐intensity interval training (HIIT) modulate inflammasome‐related gene expression in individuals with obesity. HIIT increased AIM2, MEFV, CARD16 and CARD18 expression, with CARD16 upregulation supporting reduced inflammation through inhibition of caspase‐1 activation and lower IL‐1β levels.
Ana Luíza Pereira Assunção Silveira, Daniela Alves de Abreu, Amanda de Lima Santos Musto, Luiz Henrique da Silva Nali, Jônatas Bussador do Amaral, André Luis Lacerda Bachi, Marina Tiemi Shio, Paula Rezende‐Teixeira, Carolina Nunes França   +8 more
wiley   +1 more source

Influence of Chronotype on Cycling Performance in Simulated 20‐km Time Trials—A Pilot Study

Journal of Sleep Research, EarlyView.
Evening‐type athletes show improved cycling performance later in the day, whilst morning types peak earlier. These differences appear linked to variations in mental readiness and sleepiness, highlighting the importance of considering chronotype in performance planning.
Sabrina Forster, Sascha Schwindling, Chris Abbiss, Fabienne Döringer, Andreas Klütsch, Anne Hecksteden, Tim Meyer   +6 more
wiley   +1 more source

Gut Microbiota‐Derived Extracellular Vesicles in Patients With Obesity Undergoing Gastric Bypass Surgery

Molecular Microbiology, EarlyView.
Extracellular vesicles (EVs) have been suggested to participate in gut microbiota–host communication. While obesity and bariatric surgery have been shown to alter the gut microbiota composition, changes in gut microbiota‐EVs have not been investigated.
Jenni Hekkala, Anna Kaisanlahti, Mysore V. Tejesvi, Jenni Turunen, Nikke Virtanen, Sonja Karikka, Pande Putu Erawijantari, Anatoliy Samoylenko, Genevieve Bart, Seppo Vainio, Leo Lahti, Janne Hukkanen, Terhi Ruuska‐Loewald, Vesa Koivukangas, Justus Reunanen   +14 more
wiley   +1 more source

Acute deep neck infection MRI: deep learning segmentation and clinical relevance of retropharyngeal edema volume. [PDF]

Eur Radiol Exp
Viertonen VS, Sirén A, Nyman M, Huhtanen H, Klén R, Hirvonen J, Rainio O.   +6 more
europepmc   +1 more source