Results 11 to 20 of about 77,663 (265)

A Mechanistic Dissection of Multifaceted Complement Attack in Age-Related Macular Degeneration Reveals the Superiority of C3 Inhibition. [PDF]

Adv Sci (Weinh)
Complement‐mediated RPE degeneration extends beyond terminal MAC injury. A four‐hit mechanism emerges in which C3a and C5a disrupt mitochondrial function, while C3b and MAC compromise the phagolysosomal system. Upstream C3 inhibition suppresses this full spectrum of pathogenic effectors, providing broader cellular protection than C5 blockade.
Chen Z, Wang M, Liu H, Qian F.
europepmc   +2 more sources

Replacement of the RPE monolayer [PDF]

Eye, 2009
There are numerous scenarios in which replacing the diseased RPE monolayer is an attractive but as yet unrealised goal. The proof of concept that vision can be improved by placing a healthy neuroretina onto a different, healthy, underlying RPE layer is demonstrated in patch graft transplantations.
Sheridan, C. M., Mason, S., Pattwell, D. M., Kent, D., Grierson, I., Williams, R.   +5 more
openaire   +3 more sources

Antioxidant and antimicrobial potential of Ganoderma lucidum and Trametes versicolor

Türk Biyokimya Dergisi, 2022
The majority of research programs had been focused on extract from the fruiting body. However, fungal mycelium obtained by submerged cultivation also has higher pharmacological potential.
Mustafin Kairat, Bisko Nina, Blieva Raushan, Al-Maali Galeb, Krupodorova Tatyana, Narmuratova Zhanar, Saduyeva Zhazira, Zhakipbekova Aigerim   +7 more
doaj   +1 more source

Antenna Array Construction Synthesis

Известия высших учебных заведений России: Радиоэлектроника, 2018
The problem of linear antenna construction synthesize is first formulated and solved. Linear antenna consists of antenna array (AR) and power divider (PD). Linear omnidirectional AR with cosecant pattern is synthesized using partial-beam method.
V. V. Nikitin, A. D. Frantsuzov
doaj   +1 more source

Bilateral multifocal congenital simple hamartoma of the retinal pigment epithelium

Indian Journal of Ophthalmology. Case Reports, 2022
Congenital simple hamartomas of the RPE are benign, solitary, stationary, well-demarcated lesions seen in the retina. They are usually characterized by their pigmentation, superficial or deep involvement of the retinal layers and abrupt margins, and ...
Roshni Mohan, Divya Yadav, Sourabh P Behera   +2 more
doaj   +1 more source

Clinical Implementation and Perioperative Outcomes of Robot‐Assisted Pelvic Exenteration for Primary Rectal Cancer: A Multicenter Japanese Experience [PDF]

Ann Gastroenterol Surg
Robot‐assisted pelvic exenteration (RPE) was performed with acceptable perioperative outcomes in selected patients with primary rectal cancer. It may serve as a complementary approach at institutions with sufficient experience in PE, whereas open surgery remains essential for extensive or technically demanding disease.
Yamamoto S, Kagawa H, Yatabe Y, Kinugasa Y.   +3 more
europepmc   +2 more sources

Autophagy in the eye: from physiology to pathophysiology

Autophagy Reports, 2023
Autophagy is a catabolic self-degradative pathway that promotes the degradation and recycling of intracellular material through the lysosomal compartment. Although first believed to function in conditions of nutritional stress, autophagy is emerging as a
Paloma B. Liton, Kathleen Boesze-Battaglia, Michael E. Boulton, Patricia Boya, Thomas A. Ferguson, Ian G. Ganley, Anu Kauppinnen, Gordon W. Laurie, Noboru Mizushima, Hideaki Morishita, Rossella Russo, Jaya Sadda, Rajalekshmy Shyam, Debasish Sinha, Debra A. Thompson, David N. Zacks   +15 more
doaj   +1 more source

The Intersection of Serine Metabolism and Cellular Dysfunction in Retinal Degeneration

Cells, 2020
In the past, the importance of serine to pathologic or physiologic anomalies was inadequately addressed. Omics research has significantly advanced in the last two decades, and metabolomic data of various tissues has finally brought serine metabolism to ...
Tirthankar Sinha, Larissa Ikelle, Muna I. Naash, Muayyad R. Al-Ubaidi   +3 more
doaj   +1 more source

Comparison of RPE (Rating of Perceived Exertion) Scales for Session RPE

International Journal of Sports Physiology and Performance, 2019
Purpose: The session rating of perceived exertion (sRPE) is a well-accepted method of monitoring training load in athletes in many different sports. It is based on the category-ratio (0–10) RPE scale (BORG-CR10) developed by Borg. There is no evidence how substitution of the Borg 6–20 RPE scale (BORG-RPE) might influence the sRPE in athletes.
Arney, Blaine E, Glover, Reese, Fusco, Andrea, Cortis, Cristina, de Koning, Jos J, van Erp, Teun, Jaime, Salvador, Mikat, Richard P, Porcari, John P, Foster, Carl   +9 more
openaire   +5 more sources

MicroRNAs of the RPE are essential for RPE differentiation and photoreceptor maturation [PDF]

Development, 2015
Dysfunction of the retinal pigmented epithelium (RPE) results in degeneration of photoreceptors and vision loss and is correlated with common blinding disorders in humans. Although many protein-coding genes are known to be expressed in RPEs and important for their development and maintenance, virtually nothing is known about the in vivo roles of non ...
Reut Ohana, Benjamin Weiman-Kelman, Shaul Raviv, Ernst Tamm, Metsada Pasmanik-Chor, Ariel Rinon, Dvir Netanely, Ron Shamir, Arie S Salomon, Ruth Ashery-Padan   +9 more
openaire   +1 more source