Development-related mitochondrial properties of retinal pigment epithelium cells derived from hEROs [PDF]
International Journal of Ophthalmology, 2021 AIM: To explore the temporal mitochondrial characteristics of retinal pigment epithelium (RPE) cells obtained from human embryonic stem cells (hESC)-derived retinal organoids (hEROs-RPE), to verify the optimal period for using hEROs-RPE as donor cells ...
Hao-Jue Xu +3 more
doaj +1 more source
Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins [PDF]
, 2020 Background Mutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism remains unknown, it has been hypothesized that haploinsufficiency might be involved in the ...
Aramburu, Ana +13 more
core +2 more sources
Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration
Cell Death and Disease, 2017 Age-related macular degeneration (AMD) is a devastating neurodegenerative disease and a major cause of blindness in the developed world. Owing to its complexity and the lack of an adequate human model that recapitulates key aspects of the disease, the ...
N. Golestaneh +4 more
semanticscholar +1 more source
Replacement of the RPE monolayer [PDF]
Eye, 2009 There are numerous scenarios in which replacing the diseased RPE monolayer is an attractive but as yet unrealised goal. The proof of concept that vision can be improved by placing a healthy neuroretina onto a different, healthy, underlying RPE layer is demonstrated in patch graft transplantations.
Sheridan, C. M. +5 more
openaire +3 more sources
The sustainable delivery of sexual violence prevention education in schools [PDF]
, 2015 Sexual violence is a crime that cannot be ignored: it causes our communities significant consequences including heavy economic costs, and evidence of its effects can be seen in our criminal justice system, public health system, Accident Compensation ...
Good, G, Julich, SJ, Oak, E, Terrell, J
core +4 more sources
POWER AND INFORMATION SYSTEM OF LINEAR COMPLEX OF SWITCHING DEVICES
Вестник Северо-Кавказского федерального университета, 2022 Power lines icing can cause serious accidents up to fall of poles and wire break. An effective way , get rid of ice on wires is its fusion of electric shock.
Andrey Koltsov +7 more
doaj
Autophagy in the eye: from physiology to pathophysiology
Autophagy Reports, 2023 Autophagy is a catabolic self-degradative pathway that promotes the degradation and recycling of intracellular material through the lysosomal compartment. Although first believed to function in conditions of nutritional stress, autophagy is emerging as a
Paloma B. Liton +15 more
doaj +1 more source
Early stages of retinal development depend on Sec13 function [PDF]
, 2013 Summary ER-to-Golgi transport of proteins destined for the extracellular space or intracellular compartments depends on the COPII vesicle coat and is constitutive in all translationally active cells.
Cavodeassi, Florencia +3 more
core +3 more sources
Perspective on AMD Pathobiology: A Bioenergetic Crisis in the RPE
Investigative Ophthalmology and Visual Science, 2018 AMD is the leading cause of blindness in developed countries. The dry form of AMD, also known as atrophic AMD, is characterized by the death of RPE and photoreceptors.
Cody R. Fisher, D. Ferrington
semanticscholar +1 more source
Deletion of TSPO resulted in change of metabolomic profile in retinal pigment epithelial cells [PDF]
, 2019 Age-related macular degeneration is the main cause of vision loss in the aged population worldwide. Drusen, extracellular lesions formed underneath the retinal pigment epithelial (RPE) cells, are a clinical feature of AMD and associated with AMD ...
Abdulwahab Alamri +7 more
core +2 more sources