Results 61 to 70 of about 208,874 (328)
Investigative Ophthalmology and Visual Science, 2018 Purpose The RPE cells have a major role in the development of dry age-related macular degeneration (AMD). We present novel evidence that βA3/A1-crystallin, encoded by the Cryba1 gene, a protein known to be important for lysosomal clearance in the RPE ...
Sayan Ghosh +15 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Journal of Neuroinflammation, 2018 Age-related macular degeneration (AMD) is a devastating eye disease causing irreversible vision loss in the elderly. Retinal pigment epithelium (RPE), the primary cell type that is afflicted in AMD, undergoes programmed cell death in the late stages of ...
Jiangyuan Gao +4 more
semanticscholar +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
Autonomic Stress Response and Perceived Effort Jointly Inform on Dual Tasking in Aging
Brain Sciences, 2019 The study investigated, through neuroendocrinological, subjective and behavioral assessments, how aging individuals cope with locomotor-cognitive dual-tasking and whether physical activity habits influence the acute response to locomotor-cognitive ...
Giancarlo Condello +6 more
doaj +1 more source
Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation. [PDF]
PLoS Genetics, 2019 The retinal pigment epithelium (RPE) is a specialized monolayer of pigmented cells within the eye that is critical for maintaining visual system function.
Nicholas J Hanovice +10 more
doaj +1 more source
Investigative Ophthalmology and Visual Science, 2018 Purpose To determine the mechanism causing degeneration of the retinal pigment epithelium (RPE) and photoreceptors in mice after an intravenous injection of sodium iodate (NaIO3). Methods The time-dependent changes in NaIO3-induced retinal degeneration
Mayu Moriguchi +6 more
semanticscholar +1 more source
Near‐Infrared Organic Photovoltaic Electrodes for Subretinal Neurostimulation
Advanced Functional Materials, EarlyView.Organic photovoltaic electrodes based on the D18:Y6 blend enable precise and light‐controlled activation of retinal ganglion cells in a degenerating retina. NIR Light‐driven activation of retinal ganglion cells, tunable stimulation parameters, and biocompatibility with human retinal organoids highlight their potential for next‐generation prosthetics ...
Andrea Corna +10 more
wiley +1 more source
NeuroImage, 2023 The COVID-19 pandemic has led people to predict facial attractiveness from partially covered faces. Differences in the predicted and observed facial attractiveness (i.e., masked and unmasked faces, respectively) are defined as reward prediction error ...
Moe Mihara +2 more
doaj +1 more source
In-season internal and external training load quantification of an elite European soccer team [PDF]
, 2019 Elite soccer teams that participate in European competitions need to have players in the best physical and psychological status possible to play matches.
Brito, João +6 more
core +2 more sources