Results 71 to 80 of about 77,663 (265)

Zebrafish inversin mutants develop scoliosis in the absence of laterality defects

Developmental Dynamics, EarlyView.
Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick, Lorraine Eley, Deborah J. Henderson, Bill Chaudhry   +3 more
wiley   +1 more source

MIT/TFE family transcription factors, Mitf and Tfec, redundantly promote pigment cell differentiation and retinal epithelium pigmentation in teleosts

Developmental Dynamics, EarlyView.
Abstract Background Transcription factors of the MIT/TFE family—mitfa, mitfb, and tfec—play essential roles in specifying pigment cells derived from neural crest cells in vertebrates. In teleosts, which possess multiple pigment cell types, these factors exhibit partially redundant but largely distinct functions across different pigment lineages.
James Lister, Keisuke Sugiwaka, Tetsuaki Kimura, Rieko Tanaka, Makoto Goda, Hikaru Kobayashi, Chikako Inoue, Kawilarang W. A. Masengi, Kazunori Yamahira, Kiyoshi Naruse, Satoshi Ansai, Robert N. Kelsh, Masahiko Hibi, Hisashi Hashimoto   +13 more
wiley   +1 more source

Identification of miRNA signatures during the differentiation of hESCs into retinal pigment epithelial cells.

PLoS ONE, 2012
Retinal pigment epithelium (RPE) cells can be obtained through in vitro differentiation of both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
Ganlu Hu, Kevin Huang, Juehua Yu, Sailesh Gopalakrishna-Pillai, Jun Kong, He Xu, Zhenshan Liu, Kunshan Zhang, Jun Xu, Yuping Luo, Siguang Li, Yi E Sun, Linda E Iverson, Zhigang Xue, Guoping Fan   +14 more
doaj   +1 more source

Photocatalysis‐Triggered Click Reactions and Applications

European Journal of Organic Chemistry, EarlyView.
Photoclick chemistry offers broad applications ranging from materials science to bioconjugation, with precise spatiotemporal control over click reactions. Initially limited to UV activation, recent advances have extended photoclick processes to the visible and NIR regions thanks to the photocatalysis.
Margaux Walter, Jean‐Philippe Goddard, Morgan Cormier   +2 more
wiley   +1 more source

Implications of a twelve-week aerobic exercise on functional work capacity in HIV positive clients on antiretroviral therapy

Turkish Journal of Kinesiology
The implications of aerobic exercise on functional work capacity of Human Immunodeficiency Virus (HIV) positive clients on antiretroviral therapy (ART) in Uganda have been established.
Mwebaze Nicholas, Mshilla Maghanga, Edward Ojuka, Constance A.n. Nsibambi   +3 more
doaj   +1 more source

Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation.

PLoS Genetics, 2019
The retinal pigment epithelium (RPE) is a specialized monolayer of pigmented cells within the eye that is critical for maintaining visual system function.
Nicholas J Hanovice, Lyndsay L Leach, Kayleigh Slater, Ana E Gabriel, Dwight Romanovicz, Enhua Shao, Ross Collery, Edward A Burton, Kira L Lathrop, Brian A Link, Jeffrey M Gross   +10 more
doaj   +1 more source

Development of a Zebrafish Embryo‐Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research

Environmental Toxicology and Chemistry, EarlyView.
Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz, Melanie Blanc‐Legendre, Maximilian Rinderknecht, Laura Behnstedt, Sara Coordes, Luisa Reger, Sacha Sire, Xavier Cousin, Thomas Braunbeck, Lisa Baumann   +9 more
wiley   +1 more source

Cellular Toxicity of Short‐ and Long‐Term Exposures to Polystyrene Nanoplastics and Microplastics in Fish Skin Cell Derived From Fathead Minnow (Pimephales promelas)

Journal of Applied Toxicology, EarlyView.
ABSTRACT The ubiquitous presence of microplastics and nanoplastics (MNPs) is raising concerns about their impact on the health of humans and other living organisms. Due to its tiny size, this particle can accumulate and circulate in the body after uptake, resulting in a variety of harmful outcomes on the organism, such as increased oxidative stress and
Trang Thi Nguyen, Kiyun Park, Ihn‐Sil Kwak   +2 more
wiley   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Protective effect of activating TREK-TRAAK K2P on the phagocytic function of oxidative damaged human RPE

Yanke Xuebao
Objective: To observe the effect of TREK-TRAAK K2P activation on the phagocytic function of oxidative damaged human retinal pigment epithelial cells (RPE). Methods: Immunofluorescence staining was used to detect the expression of TREK-1, TREK-2 and TRAAK
ZHENG Wenbin, YU Qinghua, CHEN Jing, LI Naiyang   +3 more
doaj   +1 more source